PMID- 30172225
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20190215
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 242
DP  - 2019 Jan 1
TI  - Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced 
      depressive-like behaviors.
PG  - 52-59
LID - S0165-0327(18)31087-5 [pii]
LID - 10.1016/j.jad.2018.08.015 [doi]
AB  - BACKGROUND: Numerous studies indicate that inflammation plays important roles in 
      the development of depression. Astrocytes are crucial regulators of immune 
      response in the central nervous system, and strongly activated by 
      pro-inflammatory cytokines. We hypothesized that inhibition of activated 
      astrocytes contributed to ameliorate depressive-like symptoms. METHODS: This 
      study evaluated the antidepressant-like effect of inhibition of activated 
      astrocytes, by a well-established astrocyte inactivator fluorocitrate (FC), on a 
      lipopolysaccharide (LPS)-induced model of depression. Forced swim test (FST), 
      tail suspension test (TST) and sucrose preference test were used to assess 
      depressive-like behaviors. The expression of fibrillary acidic protein (GFAP), 
      brain-derived neurotrophic factor (BDNF) and neuroinflammation were determined in 
      the hippocampus and cortex. RESULTS: The results demonstrated that LPS increased 
      immobility time in the TST and FST, reduced sucrose preference as well. LPS also 
      enhanced the expression of IL-1beta, TNF-alpha, iNOS and GFAP, accompanying with 
      decreased expression of BDNF in the hippocampus and cortex. Inhibition of 
      activated astrocytes by FC significantly prevented LPS- induced alteration in the 
      FST, TST and sucrose preference test. Moreover, in the hippocampus and cortex, 
      inhibition of activated astrocytes by FC significantly attenuated increases of 
      neuroinflammation and GFAP whereas reversed decrease of BDNF in LPS- challenged 
      depression. CONCLUSIONS: Taken together, the results suggest that inhibition of 
      activated astrocytes ameliorates LPS-induced depressive-like behavior, providing 
      the first evidence that inhibition of activated astrocytes might represent a 
      novel therapeutic target for depression.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Wang, Yun
AU  - Wang Y
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical 
      University, Jiangsu, China.
FAU - Ni, Jing
AU  - Ni J
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical 
      University, Jiangsu, China.
FAU - Zhai, Lingyan
AU  - Zhai L
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical 
      University, Jiangsu, China.
FAU - Gao, Ce
AU  - Gao C
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical 
      University, Jiangsu, China.
FAU - Xie, Liming
AU  - Xie L
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical 
      University, Jiangsu, China.
FAU - Zhao, Lu
AU  - Zhao L
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical 
      University, Jiangsu, China.
FAU - Yin, Xiaoxing
AU  - Yin X
AD  - Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical 
      University, Jiangsu, China. Electronic address: yinxx@xzhmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180824
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Citrates)
RN  - 0 (Cytokines)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 357-89-1 (fluorocitrate)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/therapeutic use
MH  - Astrocytes/*drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Cortex/metabolism
MH  - Citrates/*pharmacology
MH  - Cytokines/metabolism
MH  - Depressive Disorder/chemically induced/metabolism/*prevention & control
MH  - Fluorescent Antibody Technique, Indirect
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/metabolism
MH  - Inflammation/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Lipopolysaccharides/*toxicity
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Real-Time Polymerase Chain Reaction
MH  - Swimming
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Activated astrocyte
OT  - Brain-derived neurotrophic factor
OT  - Depression
OT  - Lipopolysaccharide
OT  - Neuroinflammation
EDAT- 2018/09/02 06:00
MHDA- 2019/02/12 06:00
CRDT- 2018/09/02 06:00
PHST- 2018/05/21 00:00 [received]
PHST- 2018/07/05 00:00 [revised]
PHST- 2018/08/07 00:00 [accepted]
PHST- 2018/09/02 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/09/02 06:00 [entrez]
AID - S0165-0327(18)31087-5 [pii]
AID - 10.1016/j.jad.2018.08.015 [doi]
PST - ppublish
SO  - J Affect Disord. 2019 Jan 1;242:52-59. doi: 10.1016/j.jad.2018.08.015. Epub 2018 
      Aug 24.