PMID- 30172231
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20190325
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 121
IP  - Pt 1
DP  - 2018 Dec
TI  - Prenatal exposure to persistent organic pollutants and cognition and motor 
      performance in adolescence.
PG  - 13-22
LID - S0160-4120(18)30686-X [pii]
LID - 10.1016/j.envint.2018.08.030 [doi]
AB  - BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs), such as 
      polychlorinated biphenyls (PCBs), was found to be associated with poorer 
      neurological development in children. Knowledge about the effects on outcomes 
      until adolescence is limited. OBJECTIVES: To determine whether prenatal exposure 
      to POPs, particularly hydroxylated PCBs (OH-PCBs), is associated with cognitive 
      and motor development in 13- to 15-year-old children. METHODS: This prospective 
      observational cohort study is part of the Development at Adolescence and Chemical 
      Exposure (DACE)-study, a follow-up of two Dutch birth cohorts. Maternal pregnancy 
      serum levels of PCB-153 and three OH-PCBs were measured, in part of the cohort 
      also nine other PCBs and three OH-PCBs, and in another part five polybrominated 
      diphenyl ethers (PBDEs), dichloroethene (DDE), pentachlorophenol (PCP) and 
      hexabroomcyclododecane (HBCDD). Of the 188 invited adolescents, 101 (53.7%) 
      participated, 55 were boys. Cognition (intelligence, attention, verbal memory) 
      and motor performance (fine motor, ball skills, balance) were assessed. Scores 
      were classified into 'normal' (IQ > 85; scores > P15) and '(sub)clinical' 
      (IQ </= 85; scores </= P15). We used linear and logistic regression analyses, and 
      adjusted for maternal education, maternal smoking, maternal alcohol use, breast 
      feeding, and age at examination. RESULTS: Several OH-PCBs were associated with 
      more optimal sustained attention and balance. PCB-183 was associated with lower 
      total intelligence (OR: 1.29; 95%CI:0.99-1.68; P = .060), and HBCDD with lower 
      performance intelligence (OR: 3.62; 95%CI:0.97-13.49; P = .056). PCBs, OH-PCBs 
      and PBDEs were negatively associated with verbal memory. CONCLUSIONS: Prenatal 
      background exposure to several POPs can influence neuropsychological outcomes in 
      13- to 15-year-old Dutch adolescents, although exposure to most compounds does 
      not have clinically relevant consequences at adolescence.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Berghuis, Sietske A
AU  - Berghuis SA
AD  - Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, 
      University of Groningen, University Medical Center Groningen, Groningen, the 
      Netherlands. Electronic address: s.a.berghuis@umcg.nl.
FAU - Van Braeckel, Koenraad N J A
AU  - Van Braeckel KNJA
AD  - Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, 
      University of Groningen, University Medical Center Groningen, Groningen, the 
      Netherlands.
FAU - Sauer, Pieter J J
AU  - Sauer PJJ
AD  - Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, 
      University of Groningen, University Medical Center Groningen, Groningen, the 
      Netherlands.
FAU - Bos, Arend F
AU  - Bos AF
AD  - Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, 
      University of Groningen, University Medical Center Groningen, Groningen, the 
      Netherlands.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180829
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - *Cognition
MH  - Cohort Studies
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - *Maternal Exposure
MH  - Maternal-Fetal Exchange
MH  - *Motor Skills
MH  - Polychlorinated Biphenyls/*blood
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Prospective Studies
OTO - NOTNLM
OT  - Adolescent
OT  - Cognitive function
OT  - Motor skills
OT  - Persistent organic pollutant
OT  - Prenatal exposure
EDAT- 2018/09/02 06:00
MHDA- 2019/03/26 06:00
CRDT- 2018/09/02 06:00
PHST- 2018/04/10 00:00 [received]
PHST- 2018/08/04 00:00 [revised]
PHST- 2018/08/12 00:00 [accepted]
PHST- 2018/09/02 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2018/09/02 06:00 [entrez]
AID - S0160-4120(18)30686-X [pii]
AID - 10.1016/j.envint.2018.08.030 [doi]
PST - ppublish
SO  - Environ Int. 2018 Dec;121(Pt 1):13-22. doi: 10.1016/j.envint.2018.08.030. Epub 
      2018 Aug 29.