PMID- 30172396 OWN - NLM STAT- MEDLINE DCOM- 20190108 LR - 20190108 IS - 1525-3198 (Electronic) IS - 0022-0302 (Linking) VI - 101 IP - 11 DP - 2018 Nov TI - Effects of close-up body condition score and selenium-vitamin E injection on lactation performance, blood metabolites, and oxidative status in high-producing dairy cows. PG - 10495-10504 LID - S0022-0302(18)30781-1 [pii] LID - 10.3168/jds.2017-14196 [doi] AB - High-producing dairy cows with high pre-calving body condition score (BCS) are more susceptible to metabolic disorders and oxidative stress. The aim of present study was to evaluate the effects of close-up BCS and 3 times Se-vitamin E (SeE) injection on BCS change, blood metabolites, oxidative status, and milk yield in high-producing Holstein cows. A total of 136 multiparous cows were divided into 2 groups based on their BCS including high (HB = 4.00 +/- 0.20) and moderate (MB = 3.25 +/- 0.25) at 3 wk before expected calving time. Then, each group was divided into 2 subgroups: 3 rounds of SeE injection at 21 d before, and 0 and 21 d after calving (+SeE), and no SeE injection (-SeE). Four final experimental groups were HB+SeE, MB+SeE, HB-SeE, and MB-SeE (34 cows each). Results indicated that interaction effect of BCS and SeE affected serum glucose, and the MB+SeE group had the highest level. The HB cows lost more BCS compared with MB cows during the postcalving period. Moreover, serum insulin concentration increased after SeE injection. The HB cows had higher serum nonesterified fatty acids at 14 d after calving. The MB cows tended to have higher activity of blood glutathione peroxidase over the study period. Furthermore, the SeE-injected cows tended to have higher activity of blood glutathione peroxidase at 28 d after calving. Serum albumin level was increased by SeE injection. The HB cows had greater milk production than MB cows, and SeE-injected cows tended to have higher milk fat percentage and higher fat:protein ratio compared with nonsupplemented cows. It was concluded that SeE injection had beneficial effects on some blood metabolites, albumin as a blood antioxidative parameter, and lactation performance in high-producing dairy cows, especially cows with moderate close-up BCS. CI - Copyright (c) 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved. FAU - Zahrazadeh, M AU - Zahrazadeh M AD - Department of Animal Sciences, College of Agriculture, Isfahan University of Technology, PO Box 84156/83111, Isfahan, Iran. FAU - Riasi, A AU - Riasi A AD - Department of Animal Sciences, College of Agriculture, Isfahan University of Technology, PO Box 84156/83111, Isfahan, Iran. Electronic address: ariasi@cc.iut.ac.ir. FAU - Farhangfar, H AU - Farhangfar H AD - Department of Animal Sciences, College of Agriculture, University of Birjand, PO Box 615-97175, Birjand, Iran. FAU - Mahyari, S Ansari AU - Mahyari SA AD - Department of Animal Sciences, College of Agriculture, Isfahan University of Technology, PO Box 84156/83111, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20180829 PL - United States TA - J Dairy Sci JT - Journal of dairy science JID - 2985126R RN - 0 (Fatty Acids, Nonesterified) RN - 0 (Insulin) RN - 0 (Serum Albumin) RN - 1406-18-4 (Vitamin E) RN - EC 1.11.1.9 (Glutathione Peroxidase) RN - H6241UJ22B (Selenium) SB - IM MH - Animals MH - Cattle/*physiology MH - Fatty Acids, Nonesterified/blood MH - Female MH - Glutathione Peroxidase/blood MH - Insulin/blood MH - Lactation/*drug effects MH - Milk/*metabolism MH - Oxidative Stress MH - Selenium/*administration & dosage MH - Serum Albumin/analysis MH - Vitamin E/*administration & dosage OTO - NOTNLM OT - antioxidant OT - blood metabolite OT - body condition score OT - milk composition OT - transition cow EDAT- 2018/09/03 06:00 MHDA- 2019/01/09 06:00 CRDT- 2018/09/03 06:00 PHST- 2017/11/26 00:00 [received] PHST- 2018/07/04 00:00 [accepted] PHST- 2018/09/03 06:00 [pubmed] PHST- 2019/01/09 06:00 [medline] PHST- 2018/09/03 06:00 [entrez] AID - S0022-0302(18)30781-1 [pii] AID - 10.3168/jds.2017-14196 [doi] PST - ppublish SO - J Dairy Sci. 2018 Nov;101(11):10495-10504. doi: 10.3168/jds.2017-14196. Epub 2018 Aug 29.