PMID- 30172475 OWN - NLM STAT- MEDLINE DCOM- 20190827 LR - 20190827 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 276 DP - 2019 Feb 1 TI - Clinical and imaging manifestations of Takayasu's arteritis with pulmonary hypertension: A retrospective cohort study in China. PG - 224-229 LID - S0167-5273(18)32268-X [pii] LID - 10.1016/j.ijcard.2018.08.047 [doi] AB - BACKGROUND: Takayasu's arteritis with pulmonary artery involvement (PTA) is uncommon and part of which may be accompanied by pulmonary hypertension (PH). This study herein investigated the clinical presentation, imaging features, and outcomes in PTA patients with and without PH. METHODS: A total of 57 PTA patients were selected at the Beijing Chao-Yang Hospital from January 2011 to July 2017. Patients were placed into two groups, PTA-with-PH or PTA-without-PH. The clinical characteristics, imaging features, and outcomes of patients in these two groups were investigated. RESULTS: Among the 57 PTA patients, 24 were in the PTA-without-PH group and 33 were in the PTA-with-PH group. The disease duration in PTA-with-PH patients was longer than that of PTA-without-PH patients. The mean follow-up duration of 43 patients was 33.5 +/- 20.3 months, while three patients in the PTA-with-PH were deceased. The PTA-with-PH group had significantly higher prevalence of chest tightness and dyspnea, shorter 6-minute walk distance (6MWD) and higher Borg scores after walk than that the PTA-without-PH group. Imaging analyses revealed that patients had five different arterial lesions (stenosis, occlusion, vascular wall thickening, in situ thrombosis, and aneurysm), but aneurysms were only detected in patients in PTA-with-PH patients at 42%. Compared with PTA-without-PH patients, PTA-with-PH patients tended to have occlusion lesions, but less likely to have vascular wall thickening. CONCLUSIONS: Compared with PTA-without-PH patients, PTA-with-PH patients had longer disease duration, more severe symptoms and tended to be deceased during the follow-up time. In addition, PTA-with-PH patients tended to have aneurysm and occlusion vessel lesions. CI - Copyright (c) 2018. Published by Elsevier B.V. FAU - Gong, Juanni AU - Gong J AD - Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China; Beijing Institute of Respiratory Medicine, Beijing 100020, PR China. FAU - Yang, Yuanhua AU - Yang Y AD - Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China; Beijing Institute of Respiratory Medicine, Beijing 100020, PR China. Electronic address: yyh1031@sina.com. FAU - Ma, Zhanhong AU - Ma Z AD - Department of Medical Imaging, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China. FAU - Guo, Xiaojuan AU - Guo X AD - Department of Medical Imaging, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China. FAU - Wang, Jianfeng AU - Wang J AD - Department of Intervention Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China. FAU - Kuang, Tuguang AU - Kuang T AD - Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China; Beijing Institute of Respiratory Medicine, Beijing 100020, PR China. FAU - Yang, Suqiao AU - Yang S AD - Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China; Beijing Institute of Respiratory Medicine, Beijing 100020, PR China. FAU - Li, Jifeng AU - Li J AD - Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China; Beijing Institute of Respiratory Medicine, Beijing 100020, PR China. FAU - Miao, Ran AU - Miao R AD - Department of Basic Laboratory, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China. FAU - Huang, Kewu AU - Huang K AD - Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, PR China; Beijing Institute of Respiratory Medicine, Beijing 100020, PR China. Electronic address: kewuhuang@126.com. LA - eng PT - Journal Article DEP - 20180815 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM CIN - Int J Cardiol. 2019 Feb 1;276:238-239. PMID: 30391066 MH - Adult MH - China/epidemiology MH - Cohort Studies MH - Computed Tomography Angiography/*methods MH - Female MH - Humans MH - Hypertension, Pulmonary/*diagnostic imaging/*epidemiology MH - Male MH - Middle Aged MH - Retrospective Studies MH - Takayasu Arteritis/*diagnostic imaging/*epidemiology MH - Young Adult OTO - NOTNLM OT - Aneurysm OT - Pulmonary hypertension OT - Pulmonary vascular disease OT - Takayasu's arteritis EDAT- 2018/09/03 06:00 MHDA- 2019/08/28 06:00 CRDT- 2018/09/03 06:00 PHST- 2018/04/07 00:00 [received] PHST- 2018/07/15 00:00 [revised] PHST- 2018/08/13 00:00 [accepted] PHST- 2018/09/03 06:00 [pubmed] PHST- 2019/08/28 06:00 [medline] PHST- 2018/09/03 06:00 [entrez] AID - S0167-5273(18)32268-X [pii] AID - 10.1016/j.ijcard.2018.08.047 [doi] PST - ppublish SO - Int J Cardiol. 2019 Feb 1;276:224-229. doi: 10.1016/j.ijcard.2018.08.047. Epub 2018 Aug 15.