PMID- 30173737
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 223
DP  - 2018 Sep
TI  - Cross-protection of a modified-live porcine reproductive and respiratory syndrome 
      virus (PRRSV)-2 vaccine against a heterologous PRRSV-1 challenge in late-term 
      pregnancy gilts.
PG  - 119-125
LID - S0378-1135(18)30690-4 [pii]
LID - 10.1016/j.vetmic.2018.08.008 [doi]
AB  - We have evaluated the cross-protection of a modified-live virus (MLV) vaccine 
      based on porcine reproductive and respiratory syndrome virus (PRRSV)-2, against a 
      heterologous PRRSV-1 challenge in late term pregnancy gilts. Gilts were 
      vaccinated 42 days prior to breeding and then challenged intranasally with 
      PRRSV-1 at 93 days of gestation. No local or systemic adverse effects related to 
      vaccination were observed in the vaccinated gilts throughout the study. 
      Vaccination resulted in a longer gestation period, a higher number of live-born 
      and weaned piglets, and a significant decrease in the number of stillborn piglets 
      compared to the unvaccinated group. The PRRSV-2 MLV vaccine was also able to 
      significantly reduce PRRSV-1 viremia. At the time of PRRSV-1 challenge, 
      vaccinated gilts had significantly higher PRRSV-1 specific interferon-gamma secreting 
      cells but low neutralizing antibody titers against PRRSV-1 compared to 
      unvaccinated gilts. This correlated with a reduction of PRRSV-1 viremia, 
      indicating that cell-mediated rather than humoral immunity played a role in 
      PRRSV-1 clearance from the blood. Fetal thymic tissues from vaccinated pregnant 
      gilts had fewer PRRSV-1 positive cells compared to unvaccinated gilts. Taken 
      together these results indicate that vaccination of gilts with PRRSV-2 MLV 
      vaccine can provide cross-protection against PRRSV-1 challenge and improve 
      reproductive performance.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Park, Changhoon
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Park, Kee Hwan
AU  - Park KH
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Yang, Siyeon
AU  - Yang S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Park, Su-Jin
AU  - Park SJ
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea. 
      Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20180806
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Administration, Intranasal/*veterinary
MH  - Animals
MH  - Antibodies, Neutralizing/immunology
MH  - Cross Protection
MH  - Female
MH  - Fetus/virology
MH  - Interferon-gamma/metabolism
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control/virology
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*immunology
MH  - Pregnancy
MH  - *Reproduction
MH  - Stillbirth/veterinary
MH  - Swine
MH  - Vaccination/veterinary
MH  - Vaccines, Attenuated/immunology
MH  - Viral Vaccines/*immunology
MH  - Viremia/veterinary
MH  - Weaning
OTO - NOTNLM
OT  - Cross-protection
OT  - Modified-live virus vaccine
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Reproductive failure
OT  - Sow
EDAT- 2018/09/04 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/09/04 06:00
PHST- 2018/06/07 00:00 [received]
PHST- 2018/08/04 00:00 [revised]
PHST- 2018/08/04 00:00 [accepted]
PHST- 2018/09/04 06:00 [entrez]
PHST- 2018/09/04 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
AID - S0378-1135(18)30690-4 [pii]
AID - 10.1016/j.vetmic.2018.08.008 [doi]
PST - ppublish
SO  - Vet Microbiol. 2018 Sep;223:119-125. doi: 10.1016/j.vetmic.2018.08.008. Epub 2018 
      Aug 6.