PMID- 30173782 OWN - NLM STAT- MEDLINE DCOM- 20190102 LR - 20190102 IS - 2410-8650 (Electronic) IS - 1607-551X (Linking) VI - 34 IP - 9 DP - 2018 Sep TI - Metabolic syndrome and vaspin in patients with bipolar disorder. PG - 522-528 LID - S1607-551X(18)30052-4 [pii] LID - 10.1016/j.kjms.2018.04.003 [doi] AB - Metabolic disorders and abnormal levels of circulating adipokines have been reported in patients with bipolar disorder (BD). The aim of this study was to investigate the differences in the correlations of vaspin plasma levels and metabolic parameters between two groups: patients with BD and mentally healthy persons. We measured plasma levels of vaspin, metabolic parameters, and metabolic syndrome (MS) in 101 patients with BD and 90 healthy control (HC) subjects. Patients with BD were evaluated with the Young Mania Rating Scale (YMRS) to assess manic symptoms and the Hamilton Depression Scale (HDS) to assess depressive symptoms. The Global Assessment of Functioning (GAF) was used to evaluate the general functions of the patients. Body mass index (BMI), weight, waist circumference (WC), fasting glucose, and triglyceride levels of the study group were statistically higher than those of the healthy controls (p = 0.001, p < 0.001, p < 0.001, p = 0.027, and p = 0.001 respectively). Plasma levels of vaspin were 0.978 ng/ml in patients with BD and 0.292 in the HC group (p < 0.001). Our study revealed associations between metabolic parameters/metabolic syndrome and vaspin plasma concentrations in patients with BD. Vaspin can play a specific role in the pathogenesis of metabolic disorders in these subjects and can be a specific indicator substance in BD. CI - Copyright (c) 2018. Published by Elsevier Taiwan LLC. FAU - Ertekin, Hulya AU - Ertekin H AD - Department of Psychiatry, Canakkale Onsekiz Mart University, Canakkale, Turkey. Electronic address: md.ertekin@comu.edu.tr. FAU - Sahin, Basak AU - Sahin B AD - Department of Psychiatry, Canakkale Onsekiz Mart University, Canakkale, Turkey. FAU - Caliskan, Ali Metehan AU - Caliskan AM AD - Department of Psychiatry, Health Sciences University, Konya, Turkey. FAU - Inanli, Ikbal AU - Inanli I AD - Department of Psychiatry, Health Sciences University, Konya, Turkey. FAU - Ertekin, Yusuf Haydar AU - Ertekin YH AD - Department of Family Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey. LA - eng PT - Journal Article DEP - 20180424 PL - China (Republic : 1949- ) TA - Kaohsiung J Med Sci JT - The Kaohsiung journal of medical sciences JID - 100960562 RN - 0 (SERPINA12 protein, human) RN - 0 (Serpins) SB - IM MH - Adult MH - Bipolar Disorder/*blood/pathology MH - Body Mass Index MH - Female MH - Humans MH - Male MH - Metabolic Syndrome/*blood/pathology MH - Middle Aged MH - Serpins/*blood MH - Waist Circumference OTO - NOTNLM OT - Adipokines OT - Bipolar disorder OT - Metabolic syndrome OT - Vaspin EDAT- 2018/09/04 06:00 MHDA- 2019/01/03 06:00 CRDT- 2018/09/04 06:00 PHST- 2018/01/16 00:00 [received] PHST- 2018/03/26 00:00 [revised] PHST- 2018/04/13 00:00 [accepted] PHST- 2018/09/04 06:00 [entrez] PHST- 2018/09/04 06:00 [pubmed] PHST- 2019/01/03 06:00 [medline] AID - S1607-551X(18)30052-4 [pii] AID - 10.1016/j.kjms.2018.04.003 [doi] PST - ppublish SO - Kaohsiung J Med Sci. 2018 Sep;34(9):522-528. doi: 10.1016/j.kjms.2018.04.003. Epub 2018 Apr 24.