PMID- 30174226 OWN - NLM STAT- MEDLINE DCOM- 20181126 LR - 20221207 IS - 1532-8511 (Electronic) IS - 1052-3057 (Linking) VI - 27 IP - 11 DP - 2018 Nov TI - Effects of Fluoxetine on Poststroke Dysphagia: A Clinical Retrospective Study. PG - 3320-3327 LID - S1052-3057(18)30427-0 [pii] LID - 10.1016/j.jstrokecerebrovasdis.2018.07.034 [doi] AB - BACKGROUND: To investigate whether fluoxetine improves poststroke dysphagia and to detect the potential relationship between serum brain-derived neurotrophic factor (BDNF) levels and fluoxetine effects. METHODS: In this retrospective study, 159 stroke patients who met our study criteria were included. In total, 110 patients were placed in the control group, and 49 patients were placed in the fluoxetine group. Demographic and clinical characteristics of the patients were collected for the baseline assessment. Functional independence measure scores and American speech-language-hearing association/functional communication measures scores for swallowing were collected to evaluate the patients' swallowing function. Patients' serums were collected at weeks 1 and 3 after admission, and serum BDNF levels were measured by enzyme-linked immunosorbent assay. T test, chi-squared test, and general linear model analysis were performed to determine the differences between the two groups. RESULTS: A significantly higher improvement of swallowing function was observed in the fluoxetine group compared with that of the control group (P = .023). In addition, a general linear model analysis showed that the treatment of fluoxetine has a statistically significant effect on swallowing improvement after adjustment of swallowing score on admission, stroke types, and interval between the onset of stroke and admission (P = .022, R(2) = .46, adjusted R(2) = .446). There is no significant difference in the change of serum BDNF levels in the two groups (P = .269). CONCLUSIONS: This study suggests that treatment with fluoxetine in stroke patients with dysphagia may improve swallowing function. A placebo-controlled, randomized clinical trial is warranted to confirm this finding. CI - Copyright (c) 2018. Published by Elsevier Inc. FAU - Huang, Jianting AU - Huang J AD - The First Affiliated Hospital, ShenZhen Univertisy, School of Medicine, ShenZhen Second People's Hospital, ShenZhen, Guangdong 518060 , China; Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, The Teaching Affiliate of Harvard Medical School, 79/96 13(th) Street, Charlestown, MA 02129; Clinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address: huangjt68@163.com. FAU - Liu, Xuanwei AU - Liu X AD - Department of Rehabilitation Medicine, Nanao People's Hospital of Shenzhen, Dapeng New District, Shenzhen 518121, China; Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, The Teaching Affiliate of Harvard Medical School, 79/96 13(th) Street, Charlestown, MA 02129. Electronic address: liuxuanwei1000@163.com. FAU - Luo, Xun AU - Luo X AD - Kerry Rehabilitation Medicine Research Institute, Shenzhen, Guangdong, China; School of Nursing, MGH Institute of Health Professions, 36 1(st) Ave, Charlestown, MA 02129, USA. FAU - Tang, Chunzhi AU - Tang C AD - The First Affiliated Hospital, ShenZhen Univertisy, School of Medicine, ShenZhen Second People's Hospital, ShenZhen, Guangdong 518060 , China. Electronic address: jordan664@163.com. FAU - Xu, Mingzhu AU - Xu M AD - Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, The Teaching Affiliate of Harvard Medical School, 79/96 13(th) Street, Charlestown, MA 02129. Electronic address: MXU15@partners.org. FAU - Wood, Lisa AU - Wood L AD - School of Nursing, MGH Institute of Health Professions, 36 1(st) Ave, Charlestown, MA 02129, USA. Electronic address: LJWOOD@MGHIHP.EDU. FAU - Wang, Yulong AU - Wang Y AD - The First Affiliated Hospital, ShenZhen Univertisy School of Medicine, ShenZhen Second People's Hospital, ShenZhen, Guangdong 518060 , Futian distrect China. Electronic address: wangyulong@szu.edu.cn. FAU - Wang, Qing Mei AU - Wang QM AD - Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, The Teaching Affiliate of Harvard Medical School, 79/96 13(th) Street, Charlestown, MA 02129. Electronic address: wang.qingmei@mgh.harvard.edu. LA - eng PT - Journal Article DEP - 20180830 PL - United States TA - J Stroke Cerebrovasc Dis JT - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association JID - 9111633 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Serotonin Uptake Inhibitors) RN - 01K63SUP8D (Fluoxetine) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Aged MH - Aged, 80 and over MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/blood MH - Chi-Square Distribution MH - Deglutition/*drug effects MH - Deglutition Disorders/blood/*drug therapy/etiology/physiopathology MH - Female MH - Fluoxetine/adverse effects/*therapeutic use MH - Humans MH - Linear Models MH - Male MH - Middle Aged MH - Neuronal Plasticity/drug effects MH - Pilot Projects MH - Recovery of Function MH - Retrospective Studies MH - Selective Serotonin Reuptake Inhibitors/adverse effects/*therapeutic use MH - Stroke/blood/*complications/physiopathology MH - Time Factors MH - Treatment Outcome OTO - NOTNLM OT - Poststroke OT - brain-derived neurotrophic factor (BDNF) OT - dysphagia OT - fluoxetine OT - swallowing recovery EDAT- 2018/09/04 06:00 MHDA- 2018/11/27 06:00 CRDT- 2018/09/04 06:00 PHST- 2018/02/26 00:00 [received] PHST- 2018/06/25 00:00 [revised] PHST- 2018/07/21 00:00 [accepted] PHST- 2018/09/04 06:00 [pubmed] PHST- 2018/11/27 06:00 [medline] PHST- 2018/09/04 06:00 [entrez] AID - S1052-3057(18)30427-0 [pii] AID - 10.1016/j.jstrokecerebrovasdis.2018.07.034 [doi] PST - ppublish SO - J Stroke Cerebrovasc Dis. 2018 Nov;27(11):3320-3327. doi: 10.1016/j.jstrokecerebrovasdis.2018.07.034. Epub 2018 Aug 30.