PMID- 30174229
OWN - NLM
STAT- MEDLINE
DCOM- 20190910
LR  - 20230928
IS  - 2212-8778 (Electronic)
IS  - 2212-8778 (Linking)
VI  - 17
DP  - 2018 Nov
TI  - Sex dependent impact of gestational stress on predisposition to eating disorders 
      and metabolic disease.
PG  - 1-16
LID - S2212-8778(18)30624-0 [pii]
LID - 10.1016/j.molmet.2018.08.005 [doi]
AB  - OBJECTIVE: Vulnerability to eating disorders (EDs) is broadly assumed to be 
      associated with early life stress. However, a careful examination of the 
      literature shows that susceptibility to EDs may depend on the type, severity and 
      timing of the stressor and the sex of the individual. We aimed at exploring the 
      link between chronic prenatal stress and predisposition to EDs and metabolic 
      disease. METHODS: We used a chronic variable stress protocol during gestation to 
      explore the metabolic response of male and female offspring to food restriction 
      (FR), activity-based anorexia (ABA), binge eating (BE) and exposure to high fat 
      (HF) diet. RESULTS: Contrary to controls, prenatally stressed (PNS) female 
      offspring showed resistance to ABA and BE and displayed a lower metabolic rate 
      leading to hyperadiposity and obesity on HF diet. Male PNS offspring showed 
      healthy responses to FR and ABA, increased propensity to binge and improved 
      coping with HF compared to controls. We found that long-lasting abnormal 
      responses to metabolic challenge are linked to fetal programming and adult 
      hypothalamic dysregulation in PNS females, resulting from sexually dimorphic 
      adaptations in placental methylation and gene expression. CONCLUSIONS: Our 
      results show that maternal stress may have variable and even opposing effects on 
      ED risk, depending on the ED and the sex of the offspring.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier GmbH.. All rights reserved.
FAU - Schroeder, Mariana
AU  - Schroeder M
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, 
      Israel; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute 
      of Psychiatry, Munich, 80804, Germany. Electronic address: 
      marianaschroeder.mail@gmail.com.
FAU - Jakovcevski, Mira
AU  - Jakovcevski M
AD  - Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of 
      Psychiatry, Munich, 80804, Germany.
FAU - Polacheck, Tamar
AU  - Polacheck T
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, 
      Israel.
FAU - Drori, Yonat
AU  - Drori Y
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, 
      Israel.
FAU - Ben-Dor, Shifra
AU  - Ben-Dor S
AD  - Bioinformatics and Biological Computing Unit, Biological Services, Weizmann 
      Institute of Science, Rehovot, 76100, Israel.
FAU - Roh, Simone
AU  - Roh S
AD  - Department of Translational Research in Psychiatry, Max Planck Institute of 
      Psychiatry, Munich, 80804, Germany.
FAU - Chen, Alon
AU  - Chen A
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, 
      Israel; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute 
      of Psychiatry, Munich, 80804, Germany. Electronic address: 
      alon_chen@psych.mpg.de.
LA  - eng
GR  - T32 EB016652/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180820
PL  - Germany
TA  - Mol Metab
JT  - Molecular metabolism
JID - 101605730
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Binge-Eating Disorder
MH  - Body Weight/physiology
MH  - Diet, High-Fat
MH  - Feeding and Eating Disorders/*physiopathology
MH  - Female
MH  - Hypothalamus/metabolism
MH  - Insulin
MH  - Male
MH  - Metabolic Diseases/*physiopathology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Obesity/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/physiopathology
MH  - Sex Factors
MH  - Stress, Physiological/physiology
PMC - PMC6197785
OTO - NOTNLM
OT  - Activity based anorexia
OT  - Binge eating
OT  - Early life programming
OT  - Metabolic syndrome
OT  - Obesity
OT  - Stress
EDAT- 2018/09/04 06:00
MHDA- 2019/09/11 06:00
PMCR- 2018/08/20
CRDT- 2018/09/04 06:00
PHST- 2018/06/19 00:00 [received]
PHST- 2018/08/08 00:00 [revised]
PHST- 2018/08/14 00:00 [accepted]
PHST- 2018/09/04 06:00 [pubmed]
PHST- 2019/09/11 06:00 [medline]
PHST- 2018/09/04 06:00 [entrez]
PHST- 2018/08/20 00:00 [pmc-release]
AID - S2212-8778(18)30624-0 [pii]
AID - 10.1016/j.molmet.2018.08.005 [doi]
PST - ppublish
SO  - Mol Metab. 2018 Nov;17:1-16. doi: 10.1016/j.molmet.2018.08.005. Epub 2018 Aug 20.