PMID- 30175337
OWN - NLM
STAT- MEDLINE
DCOM- 20190724
LR  - 20190724
IS  - 0300-0729 (Print)
IS  - 0300-0729 (Linking)
VI  - 57
IP  - 2
DP  - 2019 Apr 1
TI  - Responsiveness and minimal clinically important difference for the EQ-5D in 
      chronic rhinosinusitis.
PG  - 110-116
LID - 10.4193/Rhin18.122 [doi]
AB  - BACKGROUND: The 5-dimensional EuroQol questionnaire (EQ-5D) is validated to 
      measure general health-related quality of life (QOL). Our objective was to 
      determine the responsiveness and minimal clinically important difference (MCID) 
      of the EQ-5D health utility value (EQ-5D HUV) and visual analog scale (EQ-5D VAS) 
      in chronic rhinosinusitis (CRS). METHODS: 203 adults undergoing medical 
      management for CRS were prospectively recruited. General health-related QOL 
      (using EQ-5D HUV and EQ-5D VAS) and CRS-specific QOL (using the 22-item Sinonasal 
      Outcome Test [SNOT-22]) were measured at enrollment and a subsequent follow-up 
      time point 2-12 months later. At follow-up, participants also rated change in 
      general health as Much worse, A little worse, About the same, A little better or 
      Much better compared to enrollment. The EQ-5D HUV and EQ-5D VAS MCIDs were 
      calculated using distribution-based, anchor-based, and receiver operator 
      characteristic (ROC) curve-based methods. RESULTS: Change in SNOT-22 score was 
      correlated with EQ-5D HUV and EQ-5D VAS change. Using the different methods of 
      calculating MCID, we find the EQ-5D HUV MCID to be 0.04 and EQ-5D VAS MCID to be 
      8.0. The calculated EQ-5D MCIDs had approximately a sensitivity of 40-50% and 
      specificity of 80% in detecting patients experiencing noticeable improvement in 
      general health. CONCLUSIONS: The EQ-5D responds well to changing CRS 
      symptomatology. We propose MCIDs for EQ-5D HUV of 0.04 and EQ-5D VAS of 8 in CRS 
      patients, which although specific, are not sensitive for detecting patients 
      experiencing improvement in general health.
FAU - Hoehle, L P
AU  - Hoehle LP
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
FAU - Phillips, K M
AU  - Phillips KM
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
FAU - Speth, M M
AU  - Speth MM
AD  - Klinik fur Hals-, Nasen-, Ohren- Krankheiten, Hals-und Gesichtschirurgie, 
      Kantonsspital Aarau, Switzerland.
FAU - Caradonna, D S
AU  - Caradonna DS
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
FAU - Gray, S T
AU  - Gray ST
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
FAU - Sedaghat, A R
AU  - Sedaghat AR
AD  - Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Rhinology
JT  - Rhinology
JID - 0347242
MH  - Adult
MH  - Chronic Disease
MH  - Humans
MH  - *Minimal Clinically Important Difference
MH  - Quality of Life
MH  - *Sinusitis/diagnosis
MH  - Surveys and Questionnaires
EDAT- 2018/09/04 06:00
MHDA- 2019/07/25 06:00
CRDT- 2018/09/04 06:00
PHST- 2018/09/04 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
PHST- 2018/09/04 06:00 [entrez]
AID - 1839 [pii]
AID - 10.4193/Rhin18.122 [doi]
PST - ppublish
SO  - Rhinology. 2019 Apr 1;57(2):110-116. doi: 10.4193/Rhin18.122.