PMID- 30176955
OWN - NLM
STAT- MEDLINE
DCOM- 20200602
LR  - 20220409
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 49
IP  - 10
DP  - 2019 Jul
TI  - Clinical and functional characteristics of youth at clinical high-risk for 
      psychosis who do not transition to psychosis.
PG  - 1670-1677
LID - 10.1017/S0033291718002258 [doi]
AB  - BACKGROUND: Much of the interest in youth at clinical high risk (CHR) of 
      psychosis has been in understanding conversion. Recent literature has suggested 
      that less than 25% of those who meet established criteria for being at CHR of 
      psychosis go on to develop a psychotic illness. However, little is known about 
      the outcome of those who do not make the transition to psychosis. The aim of this 
      paper was to examine clinical symptoms and functioning in the second North 
      American Prodrome Longitudinal Study (NAPLS 2) of those individuals whose by the 
      end of 2 years in the study had not developed psychosis. METHODS: In NAPLS-2 278 
      CHR participants completed 2-year follow-ups and had not made the transition to 
      psychosis. At 2-years the sample was divided into three groups - those whose 
      symptoms were in remission, those who were still symptomatic and those whose 
      symptoms had become more severe. RESULTS: There was no difference between those 
      who remitted early in the study compared with those who remitted at one or 2 
      years. At 2-years, those in remission had fewer symptoms and improved functioning 
      compared with the two symptomatic groups. However, all three groups had poorer 
      social functioning and cognition than healthy controls. CONCLUSIONS: A detailed 
      examination of the clinical and functional outcomes of those who did not make the 
      transition to psychosis did not contribute to predicting who may make the 
      transition or who may have an earlier remission of attenuated psychotic symptoms.
FAU - Addington, Jean
AU  - Addington J
AD  - Department of Psychiatry,Hotchkiss Brain Institute, University of 
      Calgary,Calgary, Alberta,Canada.
FAU - Stowkowy, Jacqueline
AU  - Stowkowy J
AD  - Department of Psychiatry,Hotchkiss Brain Institute, University of 
      Calgary,Calgary, Alberta,Canada.
FAU - Liu, Lu
AU  - Liu L
AD  - Department of Psychiatry,Hotchkiss Brain Institute, University of 
      Calgary,Calgary, Alberta,Canada.
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
AD  - Department of Psychiatry,University of California San Diego,La Jolla, 
      California,USA.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology,Yale University,New Haven, CT,USA.
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
AD  - Department of Psychiatry,Zucker Hillside Hospital,Queens, NY,USA.
FAU - McGlashan, Thomas H
AU  - McGlashan TH
AD  - Department of Psychiatry,Yale University,New Haven, CT,USA.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - Department of Psychiatry,University of North Carolina,Chapel Hill, NC,USA.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Department of Psychiatry,Harvard Medical School at Beth Israel Deaconess Medical 
      Center and Massachusetts General Hospital,Boston, MA,USA.
FAU - Tsuang, Ming T
AU  - Tsuang MT
AD  - Department of Psychiatry,University of California San Diego,La Jolla, 
      California,USA.
FAU - Walker, Elaine F
AU  - Walker EF
AD  - Department of Psychology,Emory University,Atlanta, GA,USA.
FAU - Bearden, Carrie E
AU  - Bearden CE
AD  - Departments of Psychiatry and Biobehavioral Sciences and Psychology,University of 
      California,Los Angeles, CA,USA.
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - Department of Psychiatry,University of California,San Francisco,USA.
FAU - Santesteban-Echarri, Olga
AU  - Santesteban-Echarri O
AD  - Department of Psychiatry,Hotchkiss Brain Institute, University of 
      Calgary,Calgary, Alberta,Canada.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry,Yale University,New Haven, CT,USA.
LA  - eng
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - R01 MH060720/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - K24 MH076191/MH/NIMH NIH HHS/United States
GR  - U01 MH081902/MH/NIMH NIH HHS/United States
GR  - P50 MH066286/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
GR  - U01 MH081988/MH/NIMH NIH HHS/United States
GR  - U01 MH081857/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180904
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - North America/epidemiology
MH  - *Prodromal Symptoms
MH  - Psychotic Disorders/*epidemiology
MH  - Remission, Spontaneous
MH  - Risk
MH  - Young Adult
OTO - NOTNLM
OT  - Attenuated symptoms
OT  - clinical high risk
OT  - conversion
OT  - functioning
OT  - psychosis
EDAT- 2018/09/05 06:00
MHDA- 2020/06/03 06:00
CRDT- 2018/09/05 06:00
PHST- 2018/09/05 06:00 [pubmed]
PHST- 2020/06/03 06:00 [medline]
PHST- 2018/09/05 06:00 [entrez]
AID - S0033291718002258 [pii]
AID - 10.1017/S0033291718002258 [doi]
PST - ppublish
SO  - Psychol Med. 2019 Jul;49(10):1670-1677. doi: 10.1017/S0033291718002258. Epub 2018 
      Sep 4.