PMID- 30179254
OWN - NLM
STAT- MEDLINE
DCOM- 20190709
LR  - 20231004
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 156
IP  - 1
DP  - 2019 Jan
TI  - The essential role of complement in antibody-mediated resistance to Salmonella.
PG  - 69-73
LID - 10.1111/imm.13000 [doi]
AB  - Vaccines can serve as essential tools to prevent bacterial diseases via the 
      induction of long-lasting IgG responses. The efficacy of such vaccines depends on 
      the effector mechanisms triggered by IgG. The complement system and Fc-gamma 
      receptors (FcgammaRs) can potentially play a crucial role in IgG-mediated immunity 
      against bacterial diseases. However, their relative importance in vivo is 
      unclear, and has been the object of controversy and debate. In this brief study, 
      we have used gene-targeted mice lacking either FcgammaRI, II, II and IV or the C3 
      complement component as well as a novel mouse strain lacking both C3 and FcgammaRs to 
      conclusively show the essential role of complement in antibody-mediated host 
      resistance to Salmonella enterica systemic infection. By comparing the effect of 
      IgG2a antibodies against Salmonella O-antigen in gene-targeted mice, we 
      demonstrate that the complement system is essential for the IgG-mediated 
      reduction of bacterial numbers in the tissues.
CI  - (c) 2018 The Authors. Immunology Published by John Wiley & Sons Ltd.
FAU - Rossi, Omar
AU  - Rossi O
AD  - Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
FAU - Coward, Chris
AU  - Coward C
AD  - Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
FAU - Goh, Yun Shan
AU  - Goh YS
AD  - Singapore Immunology Network, Agency for Science, Tecnology and Research, 
      Singapore, Singapore.
FAU - Claassens, Jill W C
AU  - Claassens JWC
AD  - Department of Human Genetics, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - MacLennan, Calman A
AU  - MacLennan CA
AD  - Nuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, 
      UK.
FAU - Verbeek, Sjef J
AU  - Verbeek SJ
AD  - Department of Human Genetics, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Mastroeni, Pietro
AU  - Mastroeni P
AD  - Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
LA  - eng
GR  - G0001245/MRC_/Medical Research Council/United Kingdom
GR  - MR/P008852/1/MRC_/Medical Research Council/United Kingdom
GR  - Biotechnology and Biological Research Council (BBSRC)/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181010
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Complement C3)
RN  - 0 (Immunoglobulin G)
RN  - 0 (O Antigens)
RN  - 0 (Receptors, IgG)
RN  - 0 (Salmonella Vaccines)
SB  - IM
MH  - Animals
MH  - Bacterial Load
MH  - Complement Activation
MH  - Complement C3/genetics/*metabolism
MH  - Humans
MH  - Immunity, Humoral
MH  - Immunoglobulin G/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - O Antigens/*immunology
MH  - Receptors, IgG/genetics/*metabolism
MH  - Salmonella Infections/*immunology
MH  - Salmonella Vaccines/*immunology
MH  - Salmonella enterica/*physiology
PMC - PMC6283648
OTO - NOTNLM
OT  - Salmonella
OT  - in vivo
OT  - C3
OT  - FcgammaR
OT  - complement
OT  - infection
EDAT- 2018/09/05 06:00
MHDA- 2019/07/10 06:00
PMCR- 2018/10/10
CRDT- 2018/09/05 06:00
PHST- 2018/06/17 00:00 [received]
PHST- 2018/08/05 00:00 [revised]
PHST- 2018/08/20 00:00 [accepted]
PHST- 2018/09/05 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
PHST- 2018/09/05 06:00 [entrez]
PHST- 2018/10/10 00:00 [pmc-release]
AID - IMM13000 [pii]
AID - 10.1111/imm.13000 [doi]
PST - ppublish
SO  - Immunology. 2019 Jan;156(1):69-73. doi: 10.1111/imm.13000. Epub 2018 Oct 10.