PMID- 30181951
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230928
IS  - 2213-3232 (Print)
IS  - 2213-3232 (Electronic)
IS  - 2213-3232 (Linking)
VI  - 10
DP  - 2018
TI  - Improvement in anti-N-methyl-d-aspartate receptor antibody-mediated temporal lobe 
      epilepsy with amygdala enlargement without immunotherapy.
PG  - 96-98
LID - 10.1016/j.ebcr.2018.07.005 [doi]
AB  - Focal neuroinflammation is considered one of the hypotheses for the cause of 
      temporal lobe epilepsy (TLE) with amygdala enlargement (AE). Here, we report a 
      case involving an adult female patient with TLE-AE characterized by late-onset 
      seizures and cognitive impairment. Anti-N-methyl-d-aspartate receptor (NMDAR) 
      antibodies were detected in her cerebrospinal fluid. However, administration of 
      appropriate anti-seizure drugs (ASD), without immunotherapy, improved TLE-AE 
      associated with NMDAR antibodies. In the present case, two clinically significant 
      observations were made: 1) anti-NMDAR antibody-mediated autoimmune processes may 
      be associated with TLE-AE, and 2) appropriate administration of ASD alone can 
      improve clinical symptoms in mild cases of autoimmune epilepsy.
FAU - Taniguchi, Go
AU  - Taniguchi G
AD  - Department of Neuropsychiatry, The University of Tokyo Hospital, Japan.
FAU - Fuse, Hitomi
AU  - Fuse H
AD  - Department of Neuropsychiatry, The University of Tokyo Hospital, Japan.
FAU - Okamura, Yumiko
AU  - Okamura Y
AD  - Department of Neuropsychiatry, The University of Tokyo Hospital, Japan.
FAU - Mori, Harushi
AU  - Mori H
AD  - Department of Radiology, The University of Tokyo Hospital, Japan.
FAU - Kondo, Shinsuke
AU  - Kondo S
AD  - Department of Neuropsychiatry, The University of Tokyo Hospital, Japan.
FAU - Kasai, Kiyoto
AU  - Kasai K
AD  - Department of Neuropsychiatry, The University of Tokyo Hospital, Japan.
FAU - Takahashi, Yukitoshi
AU  - Takahashi Y
AD  - National epilepsy center, Shizuoka Institute of Epilepsy and Neurological 
      Disorders, Japan.
FAU - Tanaka, Keiko
AU  - Tanaka K
AD  - Department of cellular neurobiology, Brain research institute, Niigata 
      University, Japan.
LA  - eng
PT  - Case Reports
DEP - 20180803
PL  - United States
TA  - Epilepsy Behav Case Rep
JT  - Epilepsy & behavior case reports
JID - 101614202
PMC - PMC6120426
OTO - NOTNLM
OT  - Amygdala enlargement
OT  - Anti-N-methyl-d-aspartate receptor antibody
OT  - Autoimmune encephalitis
OT  - Temporal lobe epilepsy
EDAT- 2018/09/06 06:00
MHDA- 2018/09/06 06:01
PMCR- 2018/08/03
CRDT- 2018/09/06 06:00
PHST- 2018/05/31 00:00 [received]
PHST- 2018/07/11 00:00 [revised]
PHST- 2018/07/23 00:00 [accepted]
PHST- 2018/09/06 06:00 [entrez]
PHST- 2018/09/06 06:00 [pubmed]
PHST- 2018/09/06 06:01 [medline]
PHST- 2018/08/03 00:00 [pmc-release]
AID - S2213-3232(18)30078-1 [pii]
AID - 10.1016/j.ebcr.2018.07.005 [doi]
PST - epublish
SO  - Epilepsy Behav Case Rep. 2018 Aug 3;10:96-98. doi: 10.1016/j.ebcr.2018.07.005. 
      eCollection 2018.