PMID- 30182078
OWN - NLM
STAT- MEDLINE
DCOM- 20190628
LR  - 20190628
IS  - 2466-054X (Electronic)
IS  - 2466-0493 (Print)
IS  - 2466-0493 (Linking)
VI  - 59
IP  - 5
DP  - 2018 Sep
TI  - In vitro, in vivo, and clinical tests of a novel flexible ureteroscope for the 
      diagnosis and treatment of kidney and ureteral diseases.
PG  - 328-334
LID - 10.4111/icu.2018.59.5.328 [doi]
AB  - PURPOSE: Despite advances in flexible ureteroscopy, the high cost and long repair 
      time of ureteroscopes limit their use in the urology. We compared the performance 
      of a novel flexible ureteroscope (fURS) 'HF-EH' with that of the two contemporary 
      fURSs 'URF-P6' and 'COBRA'. MATERIALS AND METHODS: We compared in vitro 
      measurements of deflection angle, irrigation flow rate, and image quality between 
      HF-EH and URF-P6 while also inspecting renal collecting systems in five female 
      pigs. For clinical testing, we performed retrograde intrarenal surgeries using 
      HF-EH in four patients. Experienced urologists compared performance parameters 
      (irrigation, convenience, and maneuverability) between the HF-EH and COBRA. 
      RESULTS: The flow rate of HF-EH (21.0 mL/min) was worse, and its resolution (1.59 
      line pairs/mm) was inferior to that of URF-P6 (28.7 mL/min and 3.17 line 
      pairs/mm, respectively). However, HF-EH was superior to URF-P6 in terms of loss 
      of deflection angle with the insertion of accessories (1.8% vs. 12.7%). In vivo 
      and clinical testing revealed that the performance parameters of HF-EH were 
      slightly inferior to those of conventional domestic fURSs. We successfully 
      performed retrograde intrarenal surgeries using HF-EH in four patients and 
      achieved stone-free statuses in two. None of the patients exhibited any 
      procedure-related complications. CONCLUSIONS: Although we observed that two of 
      the three performance parameters of the novel ureteroscope 'HF-EH' were inferior 
      to those of the conventional ureteroscope, we successfully used HF-EH to perform 
      retrograde intrarenal surgeries in patients. Further studies on performance and 
      durability are warranted for making HF-EH commercially available.
FAU - Kim, Dai Hee
AU  - Kim DH
AD  - Department of Urology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Shin, Jung Hyun
AU  - Shin JH
AD  - Department of Urology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Choi, Se Young
AU  - Choi SY
AD  - Department of Urology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - You, Dalsan
AU  - You D
AD  - Department of Urology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Kim, Choung-Soo
AU  - Kim CS
AD  - Department of Urology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Park, Hyung Keun
AU  - Park HK
AUID- ORCID: 0000-0002-7607-4060
AD  - Department of Urology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180808
PL  - Korea (South)
TA  - Investig Clin Urol
JT  - Investigative and clinical urology
JID - 101674989
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Female
MH  - Humans
MH  - In Vitro Techniques
MH  - Kidney Calculi/diagnostic imaging/*surgery
MH  - Male
MH  - Middle Aged
MH  - Swine
MH  - Ureteral Calculi/diagnostic imaging/*surgery
MH  - *Ureteroscopes
MH  - Ureteroscopy/*instrumentation
PMC - PMC6121019
OTO - NOTNLM
OT  - Lithotripsy
OT  - Nephrolithiasis
OT  - Ureteroscopes
COIS- CONFLICTS OF INTEREST: The authors have nothing to disclose.
EDAT- 2018/09/06 06:00
MHDA- 2019/06/30 06:00
PMCR- 2018/09/01
CRDT- 2018/09/06 06:00
PHST- 2018/03/22 00:00 [received]
PHST- 2018/07/02 00:00 [accepted]
PHST- 2018/09/06 06:00 [entrez]
PHST- 2018/09/06 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
AID - 10.4111/icu.2018.59.5.328 [doi]
PST - ppublish
SO  - Investig Clin Urol. 2018 Sep;59(5):328-334. doi: 10.4111/icu.2018.59.5.328. Epub 
      2018 Aug 8.