PMID- 30182781
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20221207
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 35
IP  - 2
DP  - 2019 Feb
TI  - Postpartum assessment of the beta cell function and insulin resistance for 
      Chinese women with previous gestational diabetes mellitus.
PG  - 174-178
LID - 10.1080/09513590.2018.1512094 [doi]
AB  - Gestational diabetes mellitus (GDM) imparts a high risk of developing postpartum 
      diabetes and is considered to be an early stage of type 2 diabetes mellitus 
      (T2DM). In this study, a 75-g oral glucose tolerance test was performed on 472 
      women with GDM at 6-8 weeks after delivery. The clinical and metabolic 
      characteristics were compared between the patients with normal glucose tolerance 
      (NGT) and abnormal glucose metabolism (AGM). These data were then compared 
      between pre-diabetic and diabetic patients. A total of 37.7% of the women with 
      GDM continued to have abnormal glucose levels after delivery. Compared with the 
      women who reverted to normal, HOMA-IR was significantly higher in AGM. A multiple 
      stepwise regression analysis revealed that age, the postpartum body mass index 
      (BMI), low density lipoprotein-cholesterol (LDL-C), 2 h glucose load plasma 
      glucose (2 h PG), triglycerides (TG), hemoglobin A1c (HbA1c), 1 h glucose load 
      plasma insulin (INS) level, and 2 h INS level were independent risk factors for 
      the development of insulin resistance after delivery. This study has identified a 
      high prevalence of AGM after GDM. Insulin resistance appears to be the major 
      contributor. Any treatment to reduce the postpartum BMI and lipids level may be 
      beneficial to decrease insulin resistance.
FAU - Ma, Yuhang
AU  - Ma Y
AD  - a Department of Endocrinology and Metabolism , Shanghai General Hospital Shanghai 
      Jiao Tong University , Shanghai , China.
FAU - Wang, Nian
AU  - Wang N
AD  - a Department of Endocrinology and Metabolism , Shanghai General Hospital Shanghai 
      Jiao Tong University , Shanghai , China.
FAU - Gu, Liping
AU  - Gu L
AD  - a Department of Endocrinology and Metabolism , Shanghai General Hospital Shanghai 
      Jiao Tong University , Shanghai , China.
FAU - Wei, Xiaohui
AU  - Wei X
AD  - a Department of Endocrinology and Metabolism , Shanghai General Hospital Shanghai 
      Jiao Tong University , Shanghai , China.
FAU - Ren, Qian
AU  - Ren Q
AD  - a Department of Endocrinology and Metabolism , Shanghai General Hospital Shanghai 
      Jiao Tong University , Shanghai , China.
FAU - Huang, Qianfang
AU  - Huang Q
AD  - a Department of Endocrinology and Metabolism , Shanghai General Hospital Shanghai 
      Jiao Tong University , Shanghai , China.
FAU - Zhang, Aifang
AU  - Zhang A
AD  - a Department of Endocrinology and Metabolism , Shanghai General Hospital Shanghai 
      Jiao Tong University , Shanghai , China.
FAU - Zhang, Jiarong
AU  - Zhang J
AD  - b Department of Obstetrics and Gynecology , Shanghai General Hospital Shanghai 
      Jiao Tong University , Shanghai , China.
FAU - Peng, Yongde
AU  - Peng Y
AD  - a Department of Endocrinology and Metabolism , Shanghai General Hospital Shanghai 
      Jiao Tong University , Shanghai , China.
FAU - Wang, Yufan
AU  - Wang Y
AD  - a Department of Endocrinology and Metabolism , Shanghai General Hospital Shanghai 
      Jiao Tong University , Shanghai , China.
LA  - eng
PT  - Journal Article
DEP - 20180905
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 0 (hemoglobin A1c protein, human)
MH  - Adult
MH  - Asian People
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - China/epidemiology
MH  - Cholesterol, LDL/metabolism
MH  - Diabetes Mellitus, Type 2/epidemiology/*metabolism
MH  - Diabetes, Gestational/epidemiology/*metabolism
MH  - Female
MH  - Glucose Intolerance/epidemiology/*metabolism
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin Resistance
MH  - Insulin-Secreting Cells/*metabolism
MH  - Postpartum Period/*metabolism
MH  - Prediabetic State/epidemiology/*metabolism
MH  - Pregnancy
MH  - Regression Analysis
MH  - Risk Factors
MH  - Triglycerides/metabolism
OTO - NOTNLM
OT  - Gestational diabetes mellitus
OT  - beta cell function
OT  - insulin resistance
OT  - postpartum
EDAT- 2018/09/06 06:00
MHDA- 2019/08/14 06:00
CRDT- 2018/09/06 06:00
PHST- 2018/09/06 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2018/09/06 06:00 [entrez]
AID - 10.1080/09513590.2018.1512094 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2019 Feb;35(2):174-178. doi: 10.1080/09513590.2018.1512094. 
      Epub 2018 Sep 5.