PMID- 30183156
OWN - NLM
STAT- MEDLINE
DCOM- 20190515
LR  - 20190515
IS  - 1122-0643 (Print)
IS  - 1122-0643 (Linking)
VI  - 88
IP  - 3
DP  - 2018 Sep 4
TI  - Non-specific interstitial pneumonia and features of connective tissue disease: 
      What are the consequences of a different point of view?
PG  - 970
LID - 10.4081/monaldi.2018.970 [doi]
AB  - Patients with Interstitial Lung Disease (ILD) without a definitive diagnosis of 
      connective tissue diseases (CTD) were historically described as Undifferentiated 
      Connective Tissue Disease (UCTD-ILD). Recently a new classification, Interstitial 
      Pneumonia with Autoimmune Features (IPAF), has been proposed. Aim of this study 
      was to describe the prevalence, clinical characteristics and prognostic factors 
      of UCTD and IPAF subjects in a cohort of Non-Specific Interstitial Pneumonia 
      (NSIP) patients. This retrospective, observational study enrolled 102 adult 
      patients characterized by NSIP pattern on High Resolution Computed Tomography, 
      without a specific diagnosis of CTD. Three groups were identified according to 
      patients' characteristics: IPAF, UCTD or idiopathic NSIP (iNSIP). Forty percent, 
      27% and 55% of patients showed diagnostic criteria for IPAF, UCTD and iNSIP, 
      respectively. No significant differences in age, gender, smoking habit, pulmonary 
      function tests and three-year survival rate were observed among study groups. 
      IPAF patients with antisynthetase antibodies positivity, in comparison to IPAF 
      without antisynthetase antibodies positivity, showed more frequently an acute 
      onset (44% vs 9%, p<0.012). The presence of autoimmune features seems not to be 
      associated with better outcomes in NSIP patients. IPAF criteria seem to be more 
      representative than UCTD criteria in identifying patients with autoimmune 
      features. Further studies are needed to verify if IPAF should include patients 
      with positive antisynthetase serology.
FAU - Biffi, Alice
AU  - Biffi A
AD  - University of Milan Bicocca, Dipartimento Cardio-Toraco-Vascolare. 
      alicebiffi@alice.it.
FAU - Dei, Giulia
AU  - Dei G
FAU - De Giacomi, Federica
AU  - De Giacomi F
FAU - Stainer, Anna
AU  - Stainer A
FAU - Parma, Lorenzo Olmo
AU  - Parma LO
FAU - Pozzi, Maria Rosa
AU  - Pozzi MR
FAU - Faverio, Paola
AU  - Faverio P
FAU - Pesci, Alberto
AU  - Pesci A
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180904
PL  - Italy
TA  - Monaldi Arch Chest Dis
JT  - Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
JID - 9307314
RN  - 0 (Anti-Citrullinated Protein Antibodies)
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Antigens, Nuclear)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Aged
MH  - Anti-Citrullinated Protein Antibodies/immunology
MH  - Antibodies, Antinuclear/immunology
MH  - Antigens, Nuclear/immunology
MH  - Autoimmune Diseases/*diagnostic imaging/immunology/physiopathology
MH  - Cohort Studies
MH  - Connective Tissue Diseases/diagnostic imaging/immunology/physiopathology
MH  - Female
MH  - Humans
MH  - Lung Diseases, Interstitial/*diagnostic imaging/immunology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Pulmonary Diffusing Capacity
MH  - Retrospective Studies
MH  - Rheumatoid Factor/immunology
MH  - Undifferentiated Connective Tissue Diseases/*diagnostic 
      imaging/immunology/physiopathology
MH  - Vital Capacity
MH  - Walk Test
OTO - NOTNLM
OT  - Interstitial lung diseases
OT  - antisynthetase syndrome.
OT  - connective tissue diseases
OT  - interstitial pneumonia with autoimmune features
OT  - non-specific interstitial pneumonia
EDAT- 2018/09/06 06:00
MHDA- 2019/05/16 06:00
CRDT- 2018/09/06 06:00
PHST- 2018/05/27 00:00 [received]
PHST- 2018/08/21 00:00 [accepted]
PHST- 2018/07/29 00:00 [revised]
PHST- 2018/09/06 06:00 [entrez]
PHST- 2018/09/06 06:00 [pubmed]
PHST- 2019/05/16 06:00 [medline]
AID - 10.4081/monaldi.2018.970 [doi]
PST - epublish
SO  - Monaldi Arch Chest Dis. 2018 Sep 4;88(3):970. doi: 10.4081/monaldi.2018.970.