PMID- 30184768
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 92
DP  - 2018 Nov 1
TI  - Pharmacological application of barium containing bioactive glass in 
      gastro-duodenal ulcers.
PG  - 424-434
LID - S0928-4931(17)34875-0 [pii]
LID - 10.1016/j.msec.2018.06.068 [doi]
AB  - Peptic ulcer is prevalent in about 4% of the world population and nearly 10% of 
      people have been affected by peptic ulcer at some point in their life. Therefore, 
      there is a need for newer efficient and safe anti-ulcer agents. In the present 
      strategy, we have prepared a novel bioactive glass containing 1.3 mol% of barium 
      oxide (BaBG) and evaluated its antiulcer potential in gastroduodenal ulcer 
      models. Prophylactic effect of BaBG pretreatment was evaluated for 5 days in 
      ethanol, aspirin and pyloric ligation-induced gastric ulcer and 
      cysteamine-induced duodenal ulcer models. Repeated treatment of 10 days of BaBG 
      was evaluated in the healing ulcer model of acetic acid. BaBG significantly 
      reduced the ulcerative damage against all the five tested ulcer models. Scanning 
      electron microscope (SEM) images have shown that BaBG forms a physical protective 
      barrier over the gastro-duodenal epithelium cell. In the pyloric-ligation, 
      ethanol and aspirin models, BaBG showed significantly increased in gastric pH, 
      indicating antacid like activity. BaBG treatment significantly increased cell 
      proliferation in the pyloric model. Thus, BaBG mediates antiulcer action by 
      forming a protective physical barrier against harsh luminal factors, acid 
      neutralization and cell proliferation.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Paliwal, Pankaj
AU  - Paliwal P
AD  - Department of Pharmaceutical Engineering and Technology, Indian Institute of 
      Technology (Banaras Hindu University), Varanasi 221005, India.
FAU - Kumar, Arepalli Sampath
AU  - Kumar AS
AD  - Department of Ceramic Engineering, Indian Institute of Technology (Banaras Hindu 
      University), Varanasi 221005, India.
FAU - Tripathi, Himanshu
AU  - Tripathi H
AD  - Department of Ceramic Engineering, Indian Institute of Technology (Banaras Hindu 
      University), Varanasi 221005, India.
FAU - Singh, S P
AU  - Singh SP
AD  - Department of Ceramic Engineering, Indian Institute of Technology (Banaras Hindu 
      University), Varanasi 221005, India.
FAU - Patne, Shashikant C U
AU  - Patne SCU
AD  - Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, 
      Varanasi 221005, India.
FAU - Krishnamurthy, Sairam
AU  - Krishnamurthy S
AD  - Department of Pharmaceutical Engineering and Technology, Indian Institute of 
      Technology (Banaras Hindu University), Varanasi 221005, India. Electronic 
      address: ksairam.phe@iitbhu.ac.in.
LA  - eng
PT  - Journal Article
DEP - 20180702
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Barium Compounds)
RN  - 0 (Bioglass)
RN  - 0 (Oxides)
RN  - 24GP945V5T (Barium)
RN  - 5UX2SD1KE2 (Cysteamine)
RN  - 77603K202B (barium oxide)
SB  - IM
MH  - Animals
MH  - Barium/chemistry/pharmacology
MH  - *Barium Compounds/chemistry/pharmacology
MH  - *Ceramics/chemistry/pharmacology
MH  - Cysteamine/adverse effects/pharmacology
MH  - Disease Models, Animal
MH  - Duodenal Ulcer/chemically induced/*drug therapy/metabolism/pathology
MH  - Male
MH  - *Oxides/chemistry/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Stomach Ulcer/chemically induced/*drug therapy/metabolism/pathology
OTO - NOTNLM
OT  - Acid neutralization
OT  - Barium containing bioactive glass
OT  - Cell proliferation
OT  - Gastro-duodenal ulcer
OT  - Physical protective barrier
EDAT- 2018/09/07 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/09/07 06:00
PHST- 2017/12/18 00:00 [received]
PHST- 2018/05/28 00:00 [revised]
PHST- 2018/06/30 00:00 [accepted]
PHST- 2018/09/07 06:00 [entrez]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
AID - S0928-4931(17)34875-0 [pii]
AID - 10.1016/j.msec.2018.06.068 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2018 Nov 1;92:424-434. doi: 
      10.1016/j.msec.2018.06.068. Epub 2018 Jul 2.