PMID- 30184808
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 92
DP  - 2018 Nov 1
TI  - Self-assembled block copolymer [(BenzA)-b-(PCL)] micelles to orient randomly 
      distributed AuNPs into hollow core-shell morphology and its role as payload for 
      nanomedicines.
PG  - 790-799
LID - S0928-4931(17)33974-7 [pii]
LID - 10.1016/j.msec.2018.07.033 [doi]
AB  - Synthesis and characterization of the di-block copolymer (di-BCP) of 
      [(BenzA)-b-(PCL)] between benzyl alcohol (BenzA) and poly-varepsilon-caprolactone (PCL) 
      follow the development of micelles has been carried out. These developed 
      [(BenzA)-b-(PCL)] based micelles are acting as an adjunct to assemble and arrange 
      gold nanoparticles (AuNPs) in particular shape. Polymeric micelle driving 
      randomly arranged AuNPs to form hollow core-shell (hCS) type morphology in a 
      stringent assembler manner. The synthesis of [(BenzA)-b-(PCL)] has been performed 
      through addition polymerization methods without using any surfactants and 
      precursors. The average size of AuNPs is ~18 nm (in diameter). Interestingly, 
      di-BCP based micelles formulation and their role in arranging AuNPs into hCS is a 
      novel and unique approach to develop carrier capsules in biomedical field as well 
      as drug delivery systems (DDSs). The average core size is ~44 nm with shell size 
      of ~26 nm. However, [(BenzA)-b-(PCL)-(AuNPs)] based hCS capsules were used as 
      payload for anticancer drug doxorubicin hydrochloride (DOX) for controlled 
      release. Moreover, these [(BenzA)-b-(PCL)-(AuNPs)] based hCS are pH sensitive. It 
      disintegrates at acidic pH (~5.3) and releases DOX molecules in a sustained 
      manner. Furthermore, these [(BenzA)-b-(PCL)-(AuNPs)] based hCS are appended and 
      evidenced as best carrier capsules for nano-medicines with enhanced loading 
      efficacy (~74%) and dosage based prolonged release kinetics.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Amgoth, Chander
AU  - Amgoth C
AD  - School of Engineering Sciences and Technology, University of Hyderabad, Hyderabad 
      500046, TS, India. Electronic address: chander@uohyd.ac.in.
FAU - Suman Joshi, D S Doddapaneni
AU  - Suman Joshi DSD
AD  - Department of Biotechnology, Acharya Nagarjuna University, Guntur 522510, AP, 
      India.
FAU - Dharmapuri, Gangappa
AU  - Dharmapuri G
AD  - Department of Animal Biology, School of Life Sciences, University of Hyderabad, 
      500046 TS, India.
FAU - Lakavathu, Mohan
AU  - Lakavathu M
AD  - School of Chemistry, University of Hyderabad, Hyderabad, 500046, TS, India.
LA  - eng
PT  - Journal Article
DEP - 20180720
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Drug Carriers)
RN  - 0 (Polyesters)
RN  - 24980-41-4 (polycaprolactone)
RN  - 7440-57-5 (Gold)
RN  - 80168379AG (Doxorubicin)
RN  - LKG8494WBH (Benzyl Alcohol)
SB  - IM
MH  - Benzyl Alcohol/*chemistry
MH  - Doxorubicin/*chemistry
MH  - *Drug Carriers/chemical synthesis/chemistry
MH  - Gold/*chemistry
MH  - Metal Nanoparticles/*chemistry
MH  - Nanomedicine/*methods
MH  - Polyesters/*chemistry
OTO - NOTNLM
OT  - Block copolymers
OT  - Cell inhibition
OT  - Hollow core-shell
OT  - Polymer micelle
OT  - [(BenzA)-b-(PCL)]
EDAT- 2018/09/07 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/09/07 06:00
PHST- 2017/10/03 00:00 [received]
PHST- 2018/05/18 00:00 [revised]
PHST- 2018/07/12 00:00 [accepted]
PHST- 2018/09/07 06:00 [entrez]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
AID - S0928-4931(17)33974-7 [pii]
AID - 10.1016/j.msec.2018.07.033 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2018 Nov 1;92:790-799. doi: 
      10.1016/j.msec.2018.07.033. Epub 2018 Jul 20.