PMID- 30185710
OWN - NLM
STAT- MEDLINE
DCOM- 20190708
LR  - 20190708
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 59
IP  - 8
DP  - 2018
TI  - [Impact of mismatched HLA on graft-versus-host disease in unrelated stem cell 
      transplantation].
PG  - 1086-1094
LID - 10.11406/rinketsu.59.1086 [doi]
AB  - Graft-versus-host disease (GVHD) caused by patient and donor human leukocyte 
      antigen (HLA) mismatch is a complication of unrelated hematopoietic stem cell 
      transplantation (UR-HSCT) that leads to reduced success rates. To date, studies 
      on HLA alleles in transplant have provided important information on unrelated 
      donor selection. In this study on the effects of specific HLA alleles on acute 
      GVHD in UR-HSCT, HLA-C(＊)14:02 was found to be significantly associated with an 
      increased risk of acute GVHD. Patient HLA-C(＊)14:02 and donor HLA-C(＊)15:02 
      mismatch was usually KIR2DL-ligand mismatch in the GVH direction in Japanese 
      UR-HSCT cohort, and the higher risk of severe acute GVHD for KIR2DL-ligand 
      mismatch in GVH direction demonstrated in previous Japanese UR-HSCT study was 
      attributable to this particular mismatch combination. Recently, the risk of acute 
      GVHD after UR-HSCT was reported to be associated with the HLA-DP expression 
      level, which is associated with the variant rs9277534 located in the 
      3'untranslated region (UTR) of the HLA-DPB1 gene. We constructed phylogenetic 
      trees of HLA-DPB1 alleles using next-generation sequencing (NGS) HLA typing data 
      that included introns and 3'UTRs. Results reported that rs9277534 represented a 
      highly conserved region from exon 3 to the 3'UTR, which may lead to acute GVHD 
      via a mechanism different from that observed using T-cell epitope mismatching 
      algorithms, perhaps reflecting exon 2 polymorphisms. The usage of innovative 
      technologies such as NGS in genetic analysis and HLA typing thus has profound 
      implications in this field.
FAU - Morishima, Satoko
AU  - Morishima S
AD  - Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology 
      (Second Department of Internal Medicine), Graduate School of Medicine, University 
      of the Ryukyus.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Graft vs Host Disease/*etiology
MH  - HLA Antigens/genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Antigens Class I/genetics
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Phylogeny
MH  - Unrelated Donors
OTO - NOTNLM
OT  - Acute graft-versus-host disease
OT  - HLA mismatch
OT  - Unrelated hematopoietic stem cell transplantation
EDAT- 2018/09/07 06:00
MHDA- 2019/07/10 06:00
CRDT- 2018/09/07 06:00
PHST- 2018/09/07 06:00 [entrez]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
AID - 10.11406/rinketsu.59.1086 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2018;59(8):1086-1094. doi: 10.11406/rinketsu.59.1086.