PMID- 30186400
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 16
IP  - 3
DP  - 2018 Sep
TI  - Serum anion gap on admission predicts intensive care unit mortality in patients 
      with aortic aneurysm.
PG  - 1766-1777
LID - 10.3892/etm.2018.6391 [doi]
AB  - It has been widely reported that the serum anion gap is significantly associated 
      with mortality in intensive care unit (ICU); however, it remains unknown whether 
      the association is present in aortic aneurysm (AA) patients. The present study 
      aimed to investigate the association between the admission serum anion gap and 
      ICU mortality in AA patients. Data extracted from a publicly accessible clinical 
      database using a modifiable data mining technique were analyzed retrospectively, 
      mainly by employing multivariable logistic regression analysis. The primary study 
      outcome was ICU mortality. A total of 273 patient records were analyzed. The ICU 
      mortality was 8.79% (24/273). The median serum anion gap was significantly higher 
      in non-survivors [17.50 mEq/l, interquartile range (IQR) 15.75-22.50 mEq/l] 
      compared with survivors [13.00 mEq/l, IQR 11.00-15.00 mEq/l, P<0.001]. 
      Multivariate analysis resulted in identification of a clear association between 
      admission serum anion gap and ICU mortality in AA patients [odds ratio (OR) 1.38 
      per 1 mEq/l increase, 95% confidence interval (CI) 1.08-1.76]. The area under the 
      receiver operating characteristic curve showed an outstanding discrimination 
      ability in predicting ICU mortality (area under curve 0.8513, 95% CI 
      0.7698-0.9328). In conclusion, admission serum anion gap may serve as a strong 
      predictor of ICU mortality for AA patients.
FAU - Chen, Qinchang
AU  - Chen Q
AD  - Division of Vascular and Thyroid Surgery, Sun Yat-Sen Memorial Hospital, Sun 
      Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.
FAU - Chen, Qingui
AU  - Chen Q
AD  - Department of Medical Intensive Care Unit, First Affiliated Hospital of Sun 
      Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China.
FAU - Li, Lingling
AU  - Li L
AD  - Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 
      510080, P.R. China.
FAU - Lin, Xixia
AU  - Lin X
AD  - Division of Vascular and Thyroid Surgery, Sun Yat-Sen Memorial Hospital, Sun 
      Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.
FAU - Chang, Shih-I
AU  - Chang SI
AD  - Division of Vascular and Thyroid Surgery, Sun Yat-Sen Memorial Hospital, Sun 
      Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.
FAU - Li, Yonghui
AU  - Li Y
AD  - Division of Vascular and Thyroid Surgery, Sun Yat-Sen Memorial Hospital, Sun 
      Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.
FAU - Tian, Zhenluan
AU  - Tian Z
AD  - Division of Vascular and Thyroid Surgery, Sun Yat-Sen Memorial Hospital, Sun 
      Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.
FAU - Liu, Wei
AU  - Liu W
AD  - Division of Vascular and Thyroid Surgery, Sun Yat-Sen Memorial Hospital, Sun 
      Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.
FAU - Huang, Kai
AU  - Huang K
AD  - Division of Vascular and Thyroid Surgery, Sun Yat-Sen Memorial Hospital, Sun 
      Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180702
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6122415
OTO - NOTNLM
OT  - acid-base equilibrium
OT  - aortic aneurysm
OT  - intensive care units
OT  - mortality
OT  - prognosis
EDAT- 2018/09/07 06:00
MHDA- 2018/09/07 06:01
PMCR- 2018/07/02
CRDT- 2018/09/07 06:00
PHST- 2018/03/16 00:00 [received]
PHST- 2018/06/22 00:00 [accepted]
PHST- 2018/09/07 06:00 [entrez]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2018/09/07 06:01 [medline]
PHST- 2018/07/02 00:00 [pmc-release]
AID - ETM-0-0-6391 [pii]
AID - 10.3892/etm.2018.6391 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Sep;16(3):1766-1777. doi: 10.3892/etm.2018.6391. Epub 2018 Jul 
      2.