PMID- 30186627
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2018
DP  - 2018
TI  - Fluorescein Leakage within Recent Subretinal Hemorrhage in Pathologic Myopia: 
      Suggestive of CNV?
PG  - 4707832
LID - 10.1155/2018/4707832 [doi]
LID - 4707832
AB  - PURPOSE: To determine whether fluorescein leakage within subretinal hemorrhage is 
      definitely suggestive of choroidal neovascularization (CNV) by multimodal imaging 
      including optical coherence tomography angiography (OCTA). METHODS: Twenty-five 
      consecutive highly myopic patients (25 eyes) with fluorescein leakage within 
      subretinal hemorrhage detected within 1 month were prospectively included. All 
      patients underwent OCTA and spectral-domain optical coherence tomography 
      (SD-OCT). The OCTA and SD-OCT findings at the site of fluorescein leakage were 
      analyzed. In cases of a doubtful diagnosis, indocyanine green angiography (ICGA) 
      was also performed to differentiate myopic CNV from lacquer crack if necessary; 
      all patients were followed up by SD-OCT and/or OCTA for at least 2 weeks. 
      RESULTS: In terms of the site of fluorescein leakage, OCTA revealed an abnormal 
      vascular network in the outer retina and a choriocapillaris slab in 22 out of 25 
      eyes (88%), which were confirmed to be CNV. However, no high-flow signal was 
      observed in 3 of 25 eyes (12%). In these 3 cases, SD-OCT showed a focal rupture 
      of the retinal pigment epithelium-Bruch's membrane-choriocapillaris (RPE-BM-CC) 
      complex and a columnar hyperreflective signal of blood originating from defects 
      with a volcanic geyser-like appearance, and no exudative signs were detected. 
      Notably, all ruptures of the RPE-BM-CC complex were located exactly at lacquer 
      crack sites. Moreover, with the absorption of subretinal hemorrhage, ruptures of 
      the RPE-BM-CC complex spontaneously resolved without any intervention. 
      Considering the multimodal imaging appearance and follow-up outcomes, these 3 
      eyes were eventually diagnosed as simple bleeding associated with lacquer cracks. 
      CONCLUSIONS: Dye leakage within recent subretinal hemorrhage on FA could be 
      caused by new-onset lacquer cracks in pathologic myopia. Multimodal imaging 
      including OCTA is helpful to differentiate lacquer cracks from myopic CNV.
FAU - Mi, Lan
AU  - Mi L
AUID- ORCID: 0000-0001-6516-2527
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou 510060, China.
FAU - Zuo, Chengguo
AU  - Zuo C
AUID- ORCID: 0000-0002-4707-9751
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou 510060, China.
FAU - Zhang, Xiongze
AU  - Zhang X
AUID- ORCID: 0000-0001-5530-4202
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou 510060, China.
FAU - Liu, Bing
AU  - Liu B
AUID- ORCID: 0000-0003-3578-1030
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou 510060, China.
FAU - Peng, Yuting
AU  - Peng Y
AUID- ORCID: 0000-0002-8629-9167
AD  - Department of Ophthalmology, Guangdong Provincial Hospital of Traditional Chinese 
      Medicine, Guangzhou 510060, China.
FAU - Wen, Feng
AU  - Wen F
AUID- ORCID: 0000-0003-3319-4051
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou 510060, China.
LA  - eng
PT  - Journal Article
DEP - 20180813
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC6110035
EDAT- 2018/09/07 06:00
MHDA- 2018/09/07 06:01
PMCR- 2018/08/13
CRDT- 2018/09/07 06:00
PHST- 2018/04/03 00:00 [received]
PHST- 2018/05/23 00:00 [accepted]
PHST- 2018/09/07 06:00 [entrez]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2018/09/07 06:01 [medline]
PHST- 2018/08/13 00:00 [pmc-release]
AID - 10.1155/2018/4707832 [doi]
PST - epublish
SO  - J Ophthalmol. 2018 Aug 13;2018:4707832. doi: 10.1155/2018/4707832. eCollection 
      2018.