PMID- 30186630
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2090-0724 (Print)
IS  - 2090-0732 (Electronic)
IS  - 2090-0724 (Linking)
VI  - 2018
DP  - 2018
TI  - The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 
      Diabetes Mellitus Involves the Modulation of Thiol/Disulfide Redox State through 
      the Upregulation of Glutathione Synthesis.
PG  - 9794629
LID - 10.1155/2018/9794629 [doi]
LID - 9794629
AB  - Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and 
      insoluble polyphenols with great antioxidant properties. The aim of this study is 
      to evaluate the effects of JPP supplementation on the oxidative stress and 
      hepatic damage in a rat model of type 2 diabetes mellitus (T2DM). Diabetic rats 
      received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in 
      drinking water during 8 weeks. JPP-III attenuated hyperglycaemia and dyslipidemia 
      increased by 86% the liver content of nonprotein thiol groups and by 90% the 
      GSH/GSSG ratio by activating glutathione synthesis. Accordingly, JPP 
      supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme 
      delta-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the 
      reduction of serum aspartate aminotransferase activity and liver hypertrophy. Our 
      results support that JPP supplementation to T2DM rats decreases hepatic damage 
      most likely by increasing glutathione synthesis and modulating the 
      thiol/disulfide redox balance.
FAU - Quatrin, Andreia
AU  - Quatrin A
AUID- ORCID: 0000-0002-5793-9671
AD  - Graduate Program Food Science and Technology, Centre of Rural Sciences, Federal 
      University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.
AD  - Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food 
      Technology and Science, Centre of Rural Sciences, Federal University of Santa 
      Maria, 97105-900 Santa Maria, RS, Brazil.
FAU - Conte, Lisiane
AU  - Conte L
AUID- ORCID: 0000-0003-1338-4990
AD  - Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food 
      Technology and Science, Centre of Rural Sciences, Federal University of Santa 
      Maria, 97105-900 Santa Maria, RS, Brazil.
AD  - Graduate Program on Pharmacology, Centre of Health Sciences, Federal University 
      of Santa Maria, 97105-900 Santa Maria, RS, Brazil.
FAU - da Silva, Dariane Trivisiol
AU  - da Silva DT
AUID- ORCID: 0000-0002-2203-3335
AD  - Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food 
      Technology and Science, Centre of Rural Sciences, Federal University of Santa 
      Maria, 97105-900 Santa Maria, RS, Brazil.
AD  - Graduate Program on Pharmacology, Centre of Health Sciences, Federal University 
      of Santa Maria, 97105-900 Santa Maria, RS, Brazil.
FAU - Figueiredo, Cassieli Gehlen
AU  - Figueiredo CG
AUID- ORCID: 0000-0002-4735-9083
AD  - Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food 
      Technology and Science, Centre of Rural Sciences, Federal University of Santa 
      Maria, 97105-900 Santa Maria, RS, Brazil.
FAU - Somacal, Sabrina
AU  - Somacal S
AUID- ORCID: 0000-0002-8845-321X
AD  - Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food 
      Technology and Science, Centre of Rural Sciences, Federal University of Santa 
      Maria, 97105-900 Santa Maria, RS, Brazil.
FAU - Roehrs, Miguel
AU  - Roehrs M
AUID- ORCID: 0000-0002-8919-0351
AD  - Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food 
      Technology and Science, Centre of Rural Sciences, Federal University of Santa 
      Maria, 97105-900 Santa Maria, RS, Brazil.
FAU - Teixeira, Cibele Ferreira
AU  - Teixeira CF
AUID- ORCID: 0000-0003-0058-3827
AD  - Biogenomic Laboratory, Department of Morphology, Centre of Health Sciences, 
      Federal University of Santa Maria, Santa Maria, RS, Brazil.
FAU - Barbisan, Fernanda
AU  - Barbisan F
AUID- ORCID: 0000-0002-2960-7047
AD  - Graduate Program on Pharmacology, Centre of Health Sciences, Federal University 
      of Santa Maria, 97105-900 Santa Maria, RS, Brazil.
AD  - Biogenomic Laboratory, Department of Morphology, Centre of Health Sciences, 
      Federal University of Santa Maria, Santa Maria, RS, Brazil.
FAU - Augusti, Paula Rossini
AU  - Augusti PR
AUID- ORCID: 0000-0002-6578-5334
AD  - Department of Food Science, Federal University of Rio Grande do Sul, 91501-970 
      Porto Alegre, RS, Brazil.
FAU - Marostica Junior, Mario Roberto
AU  - Marostica Junior MR
AD  - School of Food Engineering, University of Campinas, 13083-862 Campinas, SP, 
      Brazil.
FAU - da Cruz, Ivana Beatrice Manica
AU  - da Cruz IBM
AUID- ORCID: 0000-0003-4183-5592
AD  - Department of Food Science, Federal University of Rio Grande do Sul, 91501-970 
      Porto Alegre, RS, Brazil.
FAU - Emanuelli, Tatiana
AU  - Emanuelli T
AUID- ORCID: 0000-0003-0168-3416
AD  - Graduate Program Food Science and Technology, Centre of Rural Sciences, Federal 
      University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.
AD  - Integrated Centre for Laboratory Analysis Development (NIDAL), Department of Food 
      Technology and Science, Centre of Rural Sciences, Federal University of Santa 
      Maria, 97105-900 Santa Maria, RS, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180801
PL  - United States
TA  - J Nutr Metab
JT  - Journal of nutrition and metabolism
JID - 101526296
PMC - PMC6093015
EDAT- 2018/09/07 06:00
MHDA- 2018/09/07 06:01
PMCR- 2018/08/01
CRDT- 2018/09/07 06:00
PHST- 2018/02/08 00:00 [received]
PHST- 2018/05/24 00:00 [revised]
PHST- 2018/05/31 00:00 [accepted]
PHST- 2018/09/07 06:00 [entrez]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2018/09/07 06:01 [medline]
PHST- 2018/08/01 00:00 [pmc-release]
AID - 10.1155/2018/9794629 [doi]
PST - epublish
SO  - J Nutr Metab. 2018 Aug 1;2018:9794629. doi: 10.1155/2018/9794629. eCollection 
      2018.