PMID- 30187023
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 2589-0565 (Electronic)
IS  - 2589-0557 (Print)
IS  - 2589-0557 (Linking)
VI  - 39
IP  - 1
DP  - 2018 Jan-Jun
TI  - Metabolic syndrome and cardiovascular disease risk assessment among human 
      immunodeficiency virus-infected individuals on antiretroviral therapy.
PG  - 28-33
LID - 10.4103/ijstd.IJSTD_89_16 [doi]
AB  - BACKGROUND: The association of cardiovascular risk with first-line antiretroviral 
      therapy (ART) in Indians has been a matter of concern with the background of a 
      high risk in South Asians. AIMS: This study aimed to compare metabolic syndrome 
      and its components, dyslipidemia, insulin resistance, and cardiovascular risk 
      among patients on first-line ART (Group 1) with age-matched, ART-naive human 
      immunodeficiency virus (HIV)-infected patients (Group 2) and normal controls 
      (Group 3). METHODS: Patients attending a tertiary care center in Mysore were 
      enrolled in the study after obtaining informed consent and controls were chosen 
      from relatives of patients. RESULTS: The total number of patients enrolled in the 
      study was 217 (males 111; females 106), and the mean age of these patients was 
      34.1 +/- 7.4 years. The number of patients in Group 1 (HIV+, ART experienced) was 
      76; in Group 2 (HIV+, ART naive) was 71, and in Group 3 (HIV-) was 70. There was 
      no statistically significant difference in the prevalence of metabolic syndrome 
      between the three groups. On comparing the components of metabolic syndrome, 
      serum triglycerides (mg/dl) were significantly higher in the ART group (Group 1: 
      149.5 [interquartile range (IQR): 84-187], Group 2: 108 [IQR: 74-152], and Group 
      3: 141.5 [IQR: 89-192]; P = 0.014) and serum high-density lipoprotein cholesterol 
      was higher in HIV-uninfected individuals (Group 1: 37.5 +/- 11.83, Group 2: 31.5 +/- 
      12.23, and Group 3: 40.1 +/- 12.09; P = 0.0002). There was no association between 
      metabolic syndrome, duration of HIV, and type of first-line ART. Total and 
      low-density lipoprotein (LDL) cholesterol were significantly higher in the ART 
      group. Homeostatic model assessment and Framingham scores did not reveal any 
      significant difference across the three groups. CONCLUSION: HIV-infected 
      individuals on ART had higher levels of triglycerides, LDL, and total 
      cholesterol, but no increased cardiovascular risk compared to other groups.
FAU - Idiculla, Jyothi
AU  - Idiculla J
AD  - Department of Medicine, St. John's Medical College, Bengaluru, Karnataka, India.
FAU - Swaroop, N
AU  - Swaroop N
AD  - Karnataka Health Promotion Trust, Bengaluru, Karnataka, India.
FAU - Shastri, Suresh
AU  - Shastri S
AD  - Lady Willingdon TB Centre, Bengaluru, Karnataka, India.
FAU - George, Nisha
AU  - George N
AD  - St John's Research Institute, Bengaluru, Karnataka, India.
FAU - Rewari, B B
AU  - Rewari BB
AD  - NACO, New Delhi, India.
FAU - Shet, Anita
AU  - Shet A
AD  - Department of Paediatrics, St. John's Medical College, Bengaluru, Karnataka, 
      India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Sex Transm Dis AIDS
JT  - Indian journal of sexually transmitted diseases and AIDS
JID - 101730896
PMC - PMC6111647
OTO - NOTNLM
OT  - Antiretroviral therapy
OT  - cardiovascular risk
OT  - metabolic syndrome
COIS- There are no conflicts of interest.
EDAT- 2018/09/07 06:00
MHDA- 2018/09/07 06:01
PMCR- 2018/01/01
CRDT- 2018/09/07 06:00
PHST- 2018/09/07 06:00 [entrez]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2018/09/07 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - IJSTD-39-28 [pii]
AID - 10.4103/ijstd.IJSTD_89_16 [doi]
PST - ppublish
SO  - Indian J Sex Transm Dis AIDS. 2018 Jan-Jun;39(1):28-33. doi: 
      10.4103/ijstd.IJSTD_89_16.