PMID- 30187117
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20200330
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 29
IP  - 3
DP  - 2019 Mar
TI  - Carotid stiffness and atherosclerotic risk: non-invasive quantification with 
      ultrafast ultrasound pulse wave velocity.
PG  - 1507-1517
LID - 10.1007/s00330-018-5705-7 [doi]
AB  - OBJECTIVES: To evaluate the value of ultrafast pulse wave velocity (ufPWV) for 
      the quantitative assessment of carotid stiffness and its associated with 
      atherosclerosis (AS) risk. METHODS: The present study included 233 patients with 
      hyperlipoidaemia (AS risk group) and 114 healthy adults as the control group. The 
      carotid (n = 694) intima-media thickness (cIMT), pulse wave velocity-beginning of 
      systole (PWV-BS) and pulse wave velocity-end of systole (PWV-ES) were measured on 
      sample images. Differences, distributive characteristics and correlation 
      evaluation were assessed in patients (ages 18-29, 30-39, 40-49, 50-59, 60-69 and 
      >/=70) and carotids (control group vs AS risk group). RESULTS: The cIMT, PWV-BS and 
      PWV-ES increased with age; PWV-ES and cIMT showed an early significant increase 
      in the 30-39 years group, whereas PWV-BS displayed a significant increase at 
      40-49 years compared with the 18- to 29-years group. Besides, PWV-ES correlated 
      well with age compared with PWV-BS and cIMT. For carotid level, cIMT, PWV-BS and 
      PWV-ES measurements were higher in the AS risk group compared with control. To 
      compare the value of ufPWV and cIMT in early AS assessment, we subdivided groups 
      into cIMT subgroups using a cut-off thickness of 0.050 cm. PWV-ES measurements 
      were higher in the AS risk group compared with the control in the 0.040-0.050 cm 
      (not thickened) and 0.051-0.060 cm (thickened) cIMT subgroups. CONCLUSIONS: 
      Carotid ufPWV measurement at PWV-ES is a novel modality for the early diagnosis 
      and quantitative assessment of arterial stiffness associated with atherosclerotic 
      risk. KEY POINTS: * ufPWV technique is real-time and well repeatable for 
      assessing carotid stiffness * ufPWV measurements increase and correlate well with 
      age * PWV-ES is a quantitative predictor for the early assessment of AS.
FAU - Zhu, Zheng-Qiu
AU  - Zhu ZQ
AD  - Department of Ultrasound, Affiliated Hospital of Nanjing University of CM, 
      Nanjing, 210029, China.
FAU - Chen, Ling-Shan
AU  - Chen LS
AD  - Department of Radiology, Affiliated Hospital of Nanjing University of CM, 
      Nanjing, 210029, China.
FAU - Wang, Han
AU  - Wang H
AD  - Department of Geratology, Affiliated Hospital of Nanjing University of CM, 
      Nanjing, 210029, China.
FAU - Liu, Fu-Ming
AU  - Liu FM
AD  - Department of Cardiology, Affiliated Hospital of Nanjing University of CM, 
      Nanjing, 210029, China.
FAU - Luan, Yun
AU  - Luan Y
AD  - Department of Ultrasound, Affiliated Hospital of Nanjing University of CM, 
      Nanjing, 210029, China.
FAU - Wu, Lin-Lin
AU  - Wu LL
AD  - Department of Ultrasound, Affiliated Hospital of Nanjing University of CM, 
      Nanjing, 210029, China.
FAU - Liu, Niu
AU  - Liu N
AD  - Department of Ultrasound, Affiliated Hospital of Nanjing University of CM, 
      Nanjing, 210029, China.
FAU - Wang, Pin
AU  - Wang P
AD  - Department of Endocrinology, Sichuan Academy of Medical Science and Sichuan 
      Provincial People's Hospital, Chengdu, 610000, China.
FAU - Huang, Hui
AU  - Huang H
AD  - Department of Ultrasound, Affiliated Hospital of Nanjing University of CM, 
      Nanjing, 210029, China. szcrhh007@vip.163.com.
LA  - eng
GR  - Y17048/the Research Project of Jiangsu Province Hospital of TCM/
GR  - YB2015020/the Research Project of Jiangsu Province of TCM/
PT  - Journal Article
DEP - 20180905
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Atherosclerosis/*diagnostic imaging/*physiopathology
MH  - Carotid Arteries/*diagnostic imaging/*physiopathology
MH  - Carotid Artery Diseases/*diagnostic imaging/*physiopathology
MH  - Carotid Intima-Media Thickness
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Pulse Wave Analysis
MH  - Risk Factors
MH  - Systole
MH  - Ultrasonography
MH  - *Vascular Stiffness
MH  - Young Adult
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Atherosclerosis
OT  - Carotid arteries
OT  - Carotid intima-media thickness
OT  - Pulse wave velocity
EDAT- 2018/09/07 06:00
MHDA- 2019/03/26 06:00
CRDT- 2018/09/07 06:00
PHST- 2018/04/12 00:00 [received]
PHST- 2018/08/06 00:00 [accepted]
PHST- 2018/07/25 00:00 [revised]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2018/09/07 06:00 [entrez]
AID - 10.1007/s00330-018-5705-7 [pii]
AID - 10.1007/s00330-018-5705-7 [doi]
PST - ppublish
SO  - Eur Radiol. 2019 Mar;29(3):1507-1517. doi: 10.1007/s00330-018-5705-7. Epub 2018 
      Sep 5.