PMID- 30187824
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220129
IS  - 2045-8932 (Print)
IS  - 2045-8940 (Electronic)
IS  - 2045-8932 (Linking)
VI  - 8
IP  - 4
DP  - 2018 Oct-Dec
TI  - High levels of healthcare utilization prior to diagnosis in idiopathic pulmonary 
      arterial hypertension support the feasibility of an early diagnosis algorithm: 
      the SPHInX project.
PG  - 2045894018798613
LID - 10.1177/2045894018798613 [doi]
LID - 2045894018798613
AB  - Idiopathic pulmonary arterial hypertension (iPAH) is a rare progressive, 
      life-shortening disease, usually diagnosed at an advanced stage. We hypothesize 
      that patients with iPAH exhibit patterns of health-seeking behavior before 
      diagnosis that will allow the development of earlier identification tools. The 
      Sheffield Pulmonary Hypertension IndeX (SPHInX) project aims to develop a 
      predictive algorithm based on routinely collected healthcare resource utilization 
      (HCRU) data. This report focuses on the initial feasibility of the project, 
      examining whether Hospital Episode Statistics (HES) data from the National Health 
      Service in England have sufficient richness to support the development of an 
      early diagnosis algorithm. This is a two-stage study. First, hospital 
      interactions during 2009-2014 captured in HES data identified 127,815 adult 
      patients with pulmonary hypertension (PH) ICD-10 codes, containing a probable 
      iPAH cohort with incidence and demographics similar to the reported literature. 
      HCRU was high in the three years before diagnosis. Second, to examine HCRU in 
      patients with a confirmed iPAH diagnosis, we built the SPHInX dataset 
      incorporating all patients investigated for suspected PH in the Sheffield 
      Pulmonary Vascular Disease Unit during 2008-2016 (n = 6674). For the SPHInX 
      dataset, data could be linked to HES in 98.6% of cases and patients with 
      confirmed iPAH had similar levels of pre-diagnosis HCRU. In conclusion, patients 
      with probable iPAH identified using HES and patients with confirmed iPAH have 
      high levels of HCRU for several years before diagnosis. Artificial intelligence 
      models will now be used to develop the SPHInX algorithm to screen for undiagnosed 
      iPAH in the general population.
FAU - Bergemann, Rito
AU  - Bergemann R
AD  - 1 GlaxoSmithKline, Brentford, Middlesex, UK.
AD  - 2 Current affiliation: Evalueserve Life Sciences Healthcare, London, UK.
FAU - Allsopp, James
AU  - Allsopp J
AD  - 3 Scientific Computing Group, Sheffield Teaching Hospitals Foundation Trust, 
      Sheffield, UK.
FAU - Jenner, Harvey
AU  - Jenner H
AD  - 4 IQVIA, London, UK.
FAU - Daniels, Flora Ashley
AU  - Daniels FA
AD  - 4 IQVIA, London, UK.
FAU - Drage, Edmund
AU  - Drage E
AD  - 4 IQVIA, London, UK.
FAU - Samyshkin, Yevgeniy
AU  - Samyshkin Y
AUID- ORCID: 0000-0003-3561-5585
AD  - 1 GlaxoSmithKline, Brentford, Middlesex, UK.
FAU - Schmitt, Claude
AU  - Schmitt C
AD  - 1 GlaxoSmithKline, Brentford, Middlesex, UK.
FAU - Wood, Steven
AU  - Wood S
AD  - 3 Scientific Computing Group, Sheffield Teaching Hospitals Foundation Trust, 
      Sheffield, UK.
AD  - 5 Department of Infection, Immunity & Cardiovascular Disease, University of 
      Sheffield, Sheffield, UK.
FAU - Kiely, David G
AU  - Kiely DG
AD  - 5 Department of Infection, Immunity & Cardiovascular Disease, University of 
      Sheffield, Sheffield, UK.
AD  - 6 National Pulmonary Hypertension Service (Sheffield), Sheffield Pulmonary 
      Vascular Unit, Royal Hallamshire Hospital, Sheffield, UK.
AD  - 7 INSIGNEO, University of Sheffield, Sheffield, UK.
FAU - Lawrie, Allan
AU  - Lawrie A
AD  - 5 Department of Infection, Immunity & Cardiovascular Disease, University of 
      Sheffield, Sheffield, UK.
AD  - 7 INSIGNEO, University of Sheffield, Sheffield, UK.
CN  - SPHInX Project team
LA  - eng
GR  - FS/13/48/30453/BHF_/British Heart Foundation/United Kingdom
GR  - FS/18/52/33808/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Pulm Circ
JT  - Pulmonary circulation
JID - 101557243
PMC - PMC6311599
OTO - NOTNLM
OT  - Hospital Episode Statistics
OT  - diagnosis
OT  - idiopathic pulmonary arterial hypertension
OT  - real-world data
OT  - right heart catheterization
EDAT- 2018/09/07 06:00
MHDA- 2018/09/07 06:01
PMCR- 2018/09/06
CRDT- 2018/09/07 06:00
PHST- 2018/09/07 06:00 [entrez]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2018/09/07 06:01 [medline]
PHST- 2018/09/06 00:00 [pmc-release]
AID - 10.1177_2045894018798613 [pii]
AID - 10.1177/2045894018798613 [doi]
PST - ppublish
SO  - Pulm Circ. 2018 Oct-Dec;8(4):2045894018798613. doi: 10.1177/2045894018798613.