PMID- 30187895
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 24
DP  - 2018 Sep 6
TI  - Cognitive Impairment Due to Leptin Withdrawal in Rat Offspring of Dams with 
      Maternal Diet-Induced Obesity.
PG  - 6208-6217
LID - 10.12659/MSM.911906 [doi]
AB  - BACKGROUND Obesity during pregnancy is a potential threat to the health and 
      neurodevelopment of the offspring. This study investigated the effect of maternal 
      diet-induced obesity (DIO) on the cognitive abilities of the offspring in rats. 
      MATERIAL AND METHODS Female Sprague-Dawley rats were fed a high-fat diet to 
      induce obesity, and the leptin levels in dams and offspring were evaluated using 
      ELISA. The effect of DIO on the learning and memory in offspring was measured 
      using electrophysiology and the Morris water maze test. In addition, the 
      expression of molecules related to synaptic plasticity was investigated. 
      Furthermore, the effect of leptin on neuronal cells was investigated, and the 
      influence of leptin on the regulation of calcium current activity was evaluated 
      in vitro. RESULTS Results showed that DIO dams had increased leptin levels during 
      gestation, and offspring had drastically decreased leptin levels after delivery. 
      The cognitive ability of offspring with maternal DIO was mildly impaired after 
      delivery. Furthermore, long-term potentiation in DIO neonatal offspring was lower 
      than in the control group at 2-3 weeks old; decreased expression of the leptin 
      receptor was accompanied by N-methyl-D-aspartate receptor (NMDAR) downregulation 
      during neonatal development. In addition, it was demonstrated that leptin 
      enhanced NMDAR activity and promoted calcium current activity in a 
      concentration-dependent manner. CONCLUSIONS The results indicated that the 
      neonatal offspring of DIO dams showed cognitive impairment during neonatal 
      development, which may be attributed to leptin withdrawal.
FAU - Ding, Qiuxia
AU  - Ding Q
AD  - Department of Obstetrics and Gynecology, Xinqiao Hospital, The Third Military 
      Medical University, Chongqing, China (mainland).
FAU - Zhao, Yandong
AU  - Zhao Y
AD  - Department of Neurobiology, College of Basic Medical Sciences, Chongqing Key 
      Laboratory of Neurobiology, Third Military Medical University, Chongqing, China 
      (mainland).
FAU - Yang, Ying
AU  - Yang Y
AD  - Department of Obstetrics and Gynecology, Xinqiao Hospital, The Third Military 
      Medical University, Chongqing, China (mainland).
FAU - Chen, Zhengqiong
AU  - Chen Z
AD  - Department of Obstetrics and Gynecology, Xinqiao Hospital, The Third Military 
      Medical University, Chongqing, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20180906
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Leptin)
RN  - 0 (Receptors, Leptin)
SB  - IM
MH  - Animals
MH  - Body Weight/physiology
MH  - Cognition/physiology
MH  - Cognitive Dysfunction/*metabolism
MH  - Diet, High-Fat
MH  - Female
MH  - Glucose Tolerance Test
MH  - Leptin/analysis/*metabolism
MH  - Male
MH  - Obesity/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Leptin/genetics/metabolism
MH  - Weight Gain/drug effects
PMC - PMC6139113
COIS- Conflicts of interest None.
EDAT- 2018/09/07 06:00
MHDA- 2018/12/12 06:00
PMCR- 2018/09/06
CRDT- 2018/09/07 06:00
PHST- 2018/09/07 06:00 [entrez]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/09/06 00:00 [pmc-release]
AID - 911906 [pii]
AID - 10.12659/MSM.911906 [doi]
PST - epublish
SO  - Med Sci Monit. 2018 Sep 6;24:6208-6217. doi: 10.12659/MSM.911906.