PMID- 30189228
OWN - NLM
STAT- MEDLINE
DCOM- 20190307
LR  - 20190307
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 686
DP  - 2018 Nov 1
TI  - NGF and BDNF expression in mouse DRG after spared nerve injury.
PG  - 67-73
LID - S0304-3940(18)30596-2 [pii]
LID - 10.1016/j.neulet.2018.08.051 [doi]
AB  - Neuropathic pain is initiated by a primary lesion in the peripheral nervous 
      system and spoils quality of life. Neurotrophins play important roles in the 
      development and transmission of neuropathic pain. There are conflicting reports 
      that the dorsal root ganglion (DRG) in an injured nerve contribute to neuropathic 
      pain, whereas several studies have highlighted the important contribution of the 
      DRG in a non-injured nerve. Clarifying the role of neurotrophins in neuropathic 
      pain is problematic because we cannot distinguish injured and intact neurons in 
      most peripheral nerve injury models. In the present study, to elicit neuropathic 
      pain, we used the spared nerve injury (SNI) model, in which injured DRG neurons 
      are distinguishable from intact ones, and mechanical allodynia develops in the 
      intact sural nerve skin territory. We examined nerve growth factor (NGF) and 
      brain-derived neurotrophic factor (BDNF) expression in the DRGs of SNI model 
      mice. NGF and BDNF levels increased in the injured L3 DRG, while NGF decreased in 
      the intact L5 DRG. These data offer a new point of view on the role of these 
      neurotrophins in neuropathic pain induced by peripheral nerve injury.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Terada, Yuki
AU  - Terada Y
AD  - Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical 
      University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan; Department of 
      Anesthesiology, Nara Medical University, 840, Shijo-cho Kashihara, Nara 634-8522, 
      Japan.
FAU - Morita-Takemura, Shoko
AU  - Morita-Takemura S
AD  - Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical 
      University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan. Electronic address: 
      morita@naramed-u.ac.jp.
FAU - Isonishi, Ayami
AU  - Isonishi A
AD  - Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical 
      University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
FAU - Tanaka, Tatsuhide
AU  - Tanaka T
AD  - Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical 
      University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
FAU - Okuda, Hiroshi
AU  - Okuda H
AD  - Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical 
      University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
FAU - Tatsumi, Kouko
AU  - Tatsumi K
AD  - Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical 
      University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
FAU - Shinjo, Takeaki
AU  - Shinjo T
AD  - Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical 
      University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan; Department of 
      Anesthesiology, Nara Medical University, 840, Shijo-cho Kashihara, Nara 634-8522, 
      Japan.
FAU - Kawaguchi, Masahiko
AU  - Kawaguchi M
AD  - Department of Anesthesiology, Nara Medical University, 840, Shijo-cho Kashihara, 
      Nara 634-8522, Japan.
FAU - Wanaka, Akio
AU  - Wanaka A
AD  - Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical 
      University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180903
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Ganglia, Spinal/*metabolism
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Nerve Growth Factor/*metabolism
MH  - Nerve Tissue/metabolism
MH  - Neuralgia/metabolism
MH  - Neurons/metabolism
MH  - Spinal Nerves/*injuries
OTO - NOTNLM
OT  - BDNF
OT  - Dorsal root ganglion
OT  - NGF
OT  - Neuropathic pain
OT  - Spared nerve injury
EDAT- 2018/09/07 06:00
MHDA- 2019/03/08 06:00
CRDT- 2018/09/07 06:00
PHST- 2018/05/25 00:00 [received]
PHST- 2018/08/14 00:00 [revised]
PHST- 2018/08/31 00:00 [accepted]
PHST- 2018/09/07 06:00 [pubmed]
PHST- 2019/03/08 06:00 [medline]
PHST- 2018/09/07 06:00 [entrez]
AID - S0304-3940(18)30596-2 [pii]
AID - 10.1016/j.neulet.2018.08.051 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 Nov 1;686:67-73. doi: 10.1016/j.neulet.2018.08.051. Epub 2018 
      Sep 3.