PMID- 30193154 OWN - NLM STAT- MEDLINE DCOM- 20190719 LR - 20190719 IS - 1878-5883 (Electronic) IS - 0022-510X (Linking) VI - 394 DP - 2018 Nov 15 TI - Mobile Universal Lexicon Evaluation System (MULES) in MS: Evaluation of a new visual test of rapid picture naming. PG - 1-5 LID - S0022-510X(18)30342-3 [pii] LID - 10.1016/j.jns.2018.08.019 [doi] AB - OBJECTIVE: The Mobile Universal Lexicon Evaluation System (MULES) is a test of rapid picture naming that is under investigation for concussion. MULES captures an extensive visual network, including pathways for eye movements, color perception, memory and object recognition. The purpose of this study was to introduce the MULES to visual assessment of patients with MS, and to examine associations with other tests of afferent and efferent visual function. METHODS: We administered the MULES in addition to binocular measures of low-contrast letter acuity (LCLA), high-contrast visual acuity (VA) and the King-Devick (K-D) test of rapid number naming in an MS cohort and in a group of disease-free controls. RESULTS: Among 24 patients with MS (median age 36 years, range 20-72, 64% female) and 22 disease-free controls (median age 34 years, range 19-59, 57% female), MULES test times were greater (worse) among the patients (60.0 vs. 40.0 s). Accounting for age, MS vs. control status was a predictor of MULES test times (P = .01, logistic regression). Faster testing times were noted among patients with MS who had greater (better) performance on binocular LCLA at 2.5% contrast (P < .001, linear regression, accounting for age), binocular high-contrast VA (P < .001), and K-D testing (P < .001). Both groups demonstrated approximately 10-s improvements in MULES test times between trials 1 and 2 (P < .0001, paired t-tests). CONCLUSION: The MULES test, a complex task of rapid picture naming involves an extensive visual network that captures eye movements, color perception and the characterization of objects. Color recognition, a key component of this novel assessment, is early in object processing and requires area V4 and the inferior temporal projections. MULES scores reflect performance of LCLA, a widely-used measure of visual function in MS clinical trials. These results provide evidence that the MULES test can add efficient visual screening to the assessment of patients with MS. CI - Copyright (c) 2018 Elsevier B.V. All rights reserved. FAU - Seay, Meagan AU - Seay M AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA. Electronic address: meagan.seay@nyumc.org. FAU - Akhand, Omar AU - Akhand O AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA. Electronic address: omar.akhand@nyumc.org. FAU - Galetta, Matthew S AU - Galetta MS AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA. Electronic address: matthew.galetta@nyumc.org. FAU - Cobbs, Lucy AU - Cobbs L AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA. Electronic address: lucy.cobbs@nyumc.org. FAU - Hasanaj, Lisena AU - Hasanaj L AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA. Electronic address: lisena.hasanaj@nyumc.org. FAU - Amorapanth, Prin AU - Amorapanth P AD - Physical Medicine and Rehabilitation, New York University School of Medicine, New York, NY, USA. Electronic address: prin.amorapanth@nyumc.org. FAU - Rizzo, John-Ross AU - Rizzo JR AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA; Physical Medicine and Rehabilitation, New York University School of Medicine, New York, NY, USA. Electronic address: johnross.rizzo@nyumc.org. FAU - Nolan, Rachel AU - Nolan R AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA. Electronic address: rachel.nolan@nyumc.org. FAU - Serrano, Liliana AU - Serrano L AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA. Electronic address: liliana.serrano2@nyumc.org. FAU - Rucker, Janet C AU - Rucker JC AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA; Ophthalmology, New York University School of Medicine, New York, NY, USA. Electronic address: janet.rucker@nyumc.org. FAU - Galetta, Steven L AU - Galetta SL AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA; Ophthalmology, New York University School of Medicine, New York, NY, USA. Electronic address: steven.galetta@nyumc.org. FAU - Balcer, Laura J AU - Balcer LJ AD - Departments of Neurolog, New York University School of Medicine, New York, NY, USA; Population Health, New York University School of Medicine, New York, NY, USA; Ophthalmology, New York University School of Medicine, New York, NY, USA. Electronic address: laura.balcer@nyumc.org. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180823 PL - Netherlands TA - J Neurol Sci JT - Journal of the neurological sciences JID - 0375403 SB - IM MH - Adult MH - Age Factors MH - Aged MH - Female MH - Humans MH - *Language MH - Linear Models MH - Male MH - Middle Aged MH - *Mobile Applications MH - Multiple Sclerosis/*physiopathology MH - *Names MH - Photic Stimulation MH - Vision Tests MH - Visual Acuity MH - Young Adult OTO - NOTNLM OT - Mobile Universal Lexicon Evaluation System (MULES) OT - Multiple sclerosis (MS) OT - Picture naming OT - Saccades OT - Vision EDAT- 2018/09/08 06:00 MHDA- 2019/07/20 06:00 CRDT- 2018/09/08 06:00 PHST- 2018/05/31 00:00 [received] PHST- 2018/08/02 00:00 [revised] PHST- 2018/08/21 00:00 [accepted] PHST- 2018/09/08 06:00 [pubmed] PHST- 2019/07/20 06:00 [medline] PHST- 2018/09/08 06:00 [entrez] AID - S0022-510X(18)30342-3 [pii] AID - 10.1016/j.jns.2018.08.019 [doi] PST - ppublish SO - J Neurol Sci. 2018 Nov 15;394:1-5. doi: 10.1016/j.jns.2018.08.019. Epub 2018 Aug 23.