PMID- 30193166
OWN - NLM
STAT- MEDLINE
DCOM- 20181127
LR  - 20181127
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 165
DP  - 2018 Dec 15
TI  - Transcriptomic responses of Nile tilapia (Oreochromis niloticus) liver to 
      environmental concentration of di(2-ethylhexyl)phthalate.
PG  - 70-77
LID - S0147-6513(18)30838-8 [pii]
LID - 10.1016/j.ecoenv.2018.08.100 [doi]
AB  - Di-(2-ethylhexyl) phthalate (DEHP) is currently the most frequently detected 
      phthalic acid esters (PAEs) compounds and can induce diverse toxicities on 
      aquatic organisms. To understand the molecular responses of fish to DEHP, we 
      performed transcriptomic profiles in liver of tilapia (Oreochromis niloticus) 
      which were exposed to environmental concentration of DEHP. A total of 30.10 Mb 
      and 30.16 Mb clean reads were retrieved from the control and DEHP treated 
      libraries, respectively. De-novo assembly of all the clean reads obtained 58,585 
      unigenes. After comparing the two libraries, 2814 and 1790 genes were identified 
      as significantly increased and depressed, respectively. Gene ontology (GO) 
      classification system and Kyoto Encyclopedia of Genes and Genomes (KEGG) database 
      analysis demonstrated that DEHP significantly disturbed the expression level of 
      genes associated with immunity, endocrine and reproductive system, lipid 
      metabolism and so on. Quantitative real-time PCR was performed to validate the 
      results of RNA-sequencing (RNA-seq) analysis. The resulting data provide new 
      insights for exploring the molecular basis of tilapia response to DEHP exposure.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Zhang, Linbao
AU  - Zhang L
AD  - Scientific Observing and Experimental Station of South China Sea Fishery 
      Resources & Environments, Ministry of Agriculture, Guangzhou 510300, PR China; 
      Guangdong Provincial Key Lab. of Fishery Ecology and Environment, Guangzhou 
      510300, PR China; South China Sea Fisheries Research Institute, Chinese Academy 
      of Fishery Sciences, Guangzhou 510300, PR China. Electronic address: 
      zhanglinbao1984@163.com.
FAU - Hu, Ying
AU  - Hu Y
AD  - College of Chemistry and Environmental Engineering, Shenzhen University, 
      Shenzhen, Guangdong 518060, PR China.
FAU - Sun, Wei
AU  - Sun W
AD  - Scientific Observing and Experimental Station of South China Sea Fishery 
      Resources & Environments, Ministry of Agriculture, Guangzhou 510300, PR China; 
      Guangdong Provincial Key Lab. of Fishery Ecology and Environment, Guangzhou 
      510300, PR China; South China Sea Fisheries Research Institute, Chinese Academy 
      of Fishery Sciences, Guangzhou 510300, PR China.
FAU - Chen, Si
AU  - Chen S
AD  - Scientific Observing and Experimental Station of South China Sea Fishery 
      Resources & Environments, Ministry of Agriculture, Guangzhou 510300, PR China; 
      Guangdong Provincial Key Lab. of Fishery Ecology and Environment, Guangzhou 
      510300, PR China; South China Sea Fisheries Research Institute, Chinese Academy 
      of Fishery Sciences, Guangzhou 510300, PR China.
FAU - Jia, Xiaoping
AU  - Jia X
AD  - Scientific Observing and Experimental Station of South China Sea Fishery 
      Resources & Environments, Ministry of Agriculture, Guangzhou 510300, PR China; 
      Guangdong Provincial Key Lab. of Fishery Ecology and Environment, Guangzhou 
      510300, PR China; South China Sea Fisheries Research Institute, Chinese Academy 
      of Fishery Sciences, Guangzhou 510300, PR China.
FAU - Cai, Wengui
AU  - Cai W
AD  - Scientific Observing and Experimental Station of South China Sea Fishery 
      Resources & Environments, Ministry of Agriculture, Guangzhou 510300, PR China; 
      Guangdong Provincial Key Lab. of Fishery Ecology and Environment, Guangzhou 
      510300, PR China; South China Sea Fisheries Research Institute, Chinese Academy 
      of Fishery Sciences, Guangzhou 510300, PR China. Electronic address: 
      nhscwg2017@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20180904
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Water Pollutants, Chemical)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Animals
MH  - Cichlids/*genetics/metabolism
MH  - Diethylhexyl Phthalate/*toxicity
MH  - Female
MH  - Gene Expression Profiling
MH  - Liver/*drug effects/metabolism
MH  - Real-Time Polymerase Chain Reaction
MH  - Sequence Analysis, RNA
MH  - Transcriptome/*drug effects
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - DEHP
OT  - Liver
OT  - Nile tilapia
OT  - Toxicity
OT  - Transcriptome
EDAT- 2018/09/08 06:00
MHDA- 2018/11/28 06:00
CRDT- 2018/09/08 06:00
PHST- 2018/02/02 00:00 [received]
PHST- 2018/04/13 00:00 [revised]
PHST- 2018/08/28 00:00 [accepted]
PHST- 2018/09/08 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2018/09/08 06:00 [entrez]
AID - S0147-6513(18)30838-8 [pii]
AID - 10.1016/j.ecoenv.2018.08.100 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2018 Dec 15;165:70-77. doi: 10.1016/j.ecoenv.2018.08.100. 
      Epub 2018 Sep 4.