PMID- 30194288
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20190314
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Sep 7
TI  - Cortical substrates of cue-reactivity in multiple substance dependent 
      populations: transdiagnostic relevance of the medial prefrontal cortex.
PG  - 186
LID - 10.1038/s41398-018-0220-9 [doi]
LID - 186
AB  - Elevated drug-cue elicited brain activity is one of the most widely cited, 
      transdiagnostically relevant traits of substance dependent populations. These 
      populations, however, are typically studied in isolation. The goal of this study 
      was to prospectively investigate the spatial topography of drug-cue reactivity in 
      a large set of individuals dependent on either cocaine, alcohol, or nicotine. 
      Functional MRI data was acquired from 156 substance dependent individuals (55 
      cocaine, 53 alcohol, and 48 nicotine) as they performed a standardized drug-cue 
      exposure task. Clusters of significant activation to drug-cues relative to 
      neutral cues ('hot spots') were isolated for each individual. K-means clustering 
      was used to classify the spatial topography of the hotspots in the data set. The 
      percentage of hotspots that would be reached at several distances (2-5 cm) of 
      transcranial magnetic stimulation (TMS) were calculated. One hundred and three 
      participants had at least one cluster of significant frontal cortex activity 
      (66%). K-means revealed 3 distinct clusters within the medial prefrontal cortex 
      (MPFC), left inferior frontal gyrus/insula, right premotor cortex. For the group 
      as a whole (and for alcohol users and nicotine users independently), medial 
      prefrontal cortex (BA 10) was the location of the greatest number of hotspots. 
      The frontal pole was cortical location closest to the largest percentage of 
      hotspots. While there is individual variability in the location of the 
      cue-elicited 'hot spot' these data demonstrate that elevated BOLD signal to drug 
      cues in the MPFC may be a transdiagnostic endophenotype of addiction which may 
      also be a fruitful neuromodulation target.
FAU - Hanlon, Colleen A
AU  - Hanlon CA
AD  - Department of Psychiatry and Behavioral Sciences Medical, University of South 
      Carolina, Charleston, SC, 29425, USA. hanlon@musc.edu.
AD  - Ralph H. Johnson VA Medical Center, Charleston, SC, 29425, USA. hanlon@musc.edu.
FAU - Dowdle, Logan T
AU  - Dowdle LT
AD  - Department of Psychiatry and Behavioral Sciences Medical, University of South 
      Carolina, Charleston, SC, 29425, USA.
FAU - Gibson, Nicole B
AU  - Gibson NB
AD  - Department of Psychiatry and Behavioral Sciences Medical, University of South 
      Carolina, Charleston, SC, 29425, USA.
FAU - Li, Xingbao
AU  - Li X
AD  - Department of Psychiatry and Behavioral Sciences Medical, University of South 
      Carolina, Charleston, SC, 29425, USA.
FAU - Hamilton, Sarah
AU  - Hamilton S
AD  - Department of Psychiatry and Behavioral Sciences Medical, University of South 
      Carolina, Charleston, SC, 29425, USA.
FAU - Canterberry, Melanie
AU  - Canterberry M
AD  - Department of Psychiatry and Behavioral Sciences Medical, University of South 
      Carolina, Charleston, SC, 29425, USA.
FAU - Hoffman, Michaela
AU  - Hoffman M
AD  - Department of Psychiatry and Behavioral Sciences Medical, University of South 
      Carolina, Charleston, SC, 29425, USA.
LA  - eng
GR  - T32 DA007288/DA/NIDA NIH HHS/United States
GR  - P50 DA015369/DA/NIDA NIH HHS/United States
GR  - K05 AA017435/AA/NIAAA NIH HHS/United States
GR  - UL1 TR000062/TR/NCATS NIH HHS/United States
GR  - P50 AA010761/AA/NIAAA NIH HHS/United States
GR  - F31 DA043330/DA/NIDA NIH HHS/United States
GR  - R01 DA044471/DA/NIDA NIH HHS/United States
GR  - R25 DA033680/DA/NIDA NIH HHS/United States
GR  - R01 DA036617/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180907
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - *Cues
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - *Motivation
MH  - Prefrontal Cortex/*physiopathology
MH  - Substance-Related Disorders/*physiopathology
MH  - Transcranial Magnetic Stimulation
MH  - Young Adult
PMC - PMC6128822
COIS- CH has served as a consultant for Brain Research & Development Services. The 
      other authors declare that they have no conflict of interest.
EDAT- 2018/09/09 06:00
MHDA- 2019/03/15 06:00
PMCR- 2018/09/07
CRDT- 2018/09/09 06:00
PHST- 2017/12/02 00:00 [received]
PHST- 2018/06/08 00:00 [accepted]
PHST- 2018/05/25 00:00 [revised]
PHST- 2018/09/09 06:00 [entrez]
PHST- 2018/09/09 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
PHST- 2018/09/07 00:00 [pmc-release]
AID - 10.1038/s41398-018-0220-9 [pii]
AID - 220 [pii]
AID - 10.1038/s41398-018-0220-9 [doi]
PST - epublish
SO  - Transl Psychiatry. 2018 Sep 7;8(1):186. doi: 10.1038/s41398-018-0220-9.