PMID- 30194657
OWN - NLM
STAT- MEDLINE
DCOM- 20190521
LR  - 20210109
IS  - 1861-0293 (Electronic)
IS  - 1340-3443 (Linking)
VI  - 73
IP  - 1
DP  - 2019 Jan
TI  - Ameliorative effect of Xiaoyao-jieyu-san on post-stroke depression and its 
      potential mechanisms.
PG  - 76-84
LID - 10.1007/s11418-018-1243-5 [doi]
AB  - A stroke is a severe life-threatening disease with high fatality and disability 
      rate. This investigation aimed to study the effect of Xiaoyao-jieyu-san (XYJY) on 
      post-stroke depression (PSD) and its potential mechanisms. PSD rats were prepared 
      using middle cerebral artery embolization (MCAO) and chronic unpredictable mild 
      stress (CUMS), and divided into six groups (n = 10)-sham; MCAO; MCAO + CUMS 
      (PSD); PSD + fluoxetine (1.84 mg/kg/day, 4 weeks); and PSD + XYJY (450 mg/kg/day 
      and 900 mg/kg/day, 4 weeks). Body weight recording, despair swimming test, and 
      sucrose preference test were performed at 0, 3 and 7 weeks. Histopathological 
      examination and levels of 5-hydroxytryptamine (5-HT), norepinephrine (NE) and 
      brain-derived neurotrophic factor (BDNF) in ventral tegmental area-nucleus 
      accumbens (VTA-NAc) tissue were determined at the end of a 7-week period. 
      Real-time polymerase chain reaction PCR was used to determine mRNA expression of 
      5-HT(1A)R and 5-HT(2A)R, and Western blot was performed to determine expression 
      of BDNF, corticotrophin-releasing factor (CRF), and cannabinoid receptors (CB(1)R 
      and CB(2)R) in VTA-NAc tissue. High-performance liquid chromatography coupled 
      with electrospray mass spectroscopy revealed that the constituents of XYJY are 
      mainly paeoniflorin, imperatorin, naringin, arnesene, 
      2,3,5,4'-tetrahydroxyl-diphenylethylene-2-O-glucoside, kaempferol-3-O-rutinoside, 
      quercetin, hesperidin, cycloastragenol and atractylenolide III. XYJY (900 mg/kg) 
      increased the body weight of PSD rats, while XYJY (450 mg/kg and 900 mg/kg) 
      shortened the duration of immobility and enhanced the sucrose preference of PSD 
      rats. XYJY (450 mg/kg and 900 mg/kg) increased the levels of 5-HT, NE and BNDF, 
      up-regulated mRNA expression of 5-HT(1A)R, down-regulated 5-HT(2A)R, and 
      up-regulated BNDF, CB(1)R, and CB(2)R expression in the VTA-NAc tissue of PSD 
      rats but down-regulated CRF. Collectively, the present findings suggested that 
      XYJY has an ameliorative effect on PSD in rats via modulation of BNDF, 
      cannabinoid receptors and CRF in VTA-NAc tissue.
FAU - Wang, Changde
AU  - Wang C
AD  - Department of Encephalopathy, Shanghai TCM-Integrated Hospital Affiliated to 
      Shanghai University of TCM, No. 303 Changyang Road, Hongkou District, Shanghai, 
      200082, China. 15618075507@163.com.
FAU - Wu, Chunlan
AU  - Wu C
AD  - Department of Encephalopathy, Shanghai TCM-Integrated Hospital Affiliated to 
      Shanghai University of TCM, No. 303 Changyang Road, Hongkou District, Shanghai, 
      200082, China.
FAU - Yan, Zhenguo
AU  - Yan Z
AD  - Department of Encephalopathy, Shanghai TCM-Integrated Hospital Affiliated to 
      Shanghai University of TCM, No. 303 Changyang Road, Hongkou District, Shanghai, 
      200082, China.
FAU - Cheng, Xiao
AU  - Cheng X
AD  - Department of Encephalopathy, Shanghai TCM-Integrated Hospital Affiliated to 
      Shanghai University of TCM, No. 303 Changyang Road, Hongkou District, Shanghai, 
      200082, China.
LA  - eng
GR  - 16ZR1433700/Shanghai Science and Technology Commission, Shanghai Natural Science 
      Foundation/
PT  - Journal Article
DEP - 20180907
PL  - Japan
TA  - J Nat Med
JT  - Journal of natural medicines
JID - 101518405
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (xiaoyao)
SB  - IM
MH  - Animals
MH  - Depression/*drug therapy/pathology
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Humans
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stroke/*complications
MH  - Stroke Rehabilitation/*methods/psychology
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Cannabinoids receptors
OT  - Corticotropin-releasing factor
OT  - Post-stroke depression
OT  - Xiaoyao-jieyu-san
EDAT- 2018/09/09 06:00
MHDA- 2019/05/22 06:00
CRDT- 2018/09/09 06:00
PHST- 2018/05/17 00:00 [received]
PHST- 2018/08/22 00:00 [accepted]
PHST- 2018/09/09 06:00 [pubmed]
PHST- 2019/05/22 06:00 [medline]
PHST- 2018/09/09 06:00 [entrez]
AID - 10.1007/s11418-018-1243-5 [pii]
AID - 10.1007/s11418-018-1243-5 [doi]
PST - ppublish
SO  - J Nat Med. 2019 Jan;73(1):76-84. doi: 10.1007/s11418-018-1243-5. Epub 2018 Sep 7.