PMID- 30194659
OWN - NLM
STAT- MEDLINE
DCOM- 20200721
LR  - 20200721
IS  - 1573-7039 (Electronic)
IS  - 1083-3021 (Linking)
VI  - 24
IP  - 1
DP  - 2019 Mar
TI  - Gap Junctions and Wnt Signaling in the Mammary Gland: a Cross-Talk?
PG  - 17-38
LID - 10.1007/s10911-018-9411-5 [doi]
AB  - Connexins (Cxs), the building blocks of gap junctions (GJs), exhibit 
      spatiotemporal patterns of expression and regulate the development and 
      differentiation of the mammary gland, acting via channel-dependent and 
      channel-independent mechanisms. Impaired Cx expression and localization are 
      reported in breast cancer, suggesting a tumor suppressive role for Cxs. The 
      signaling events that mediate the role of GJs in the development and 
      tumorigenesis of the mammary gland remain poorly identified. The Wnt pathways, 
      encompassing the canonical or the Wnt/beta-catenin pathway and the noncanonical 
      beta-catenin-independent pathway, also play important roles in those processes. 
      Indeed, aberrant Wnt signaling is associated with breast cancer. Despite the 
      coincident roles of Cxs and Wnt pathways, the cross-talk in the breast tissue is 
      poorly defined, although this is reported in a number of other tissues. Our 
      previous studies revealed a channel-independent role for Cx43 in inducing 
      differentiation or suppressing tumorigenesis of mammary epithelial cells by 
      acting as a negative regulator of the Wnt/beta-catenin pathway. Here, we provide a 
      brief overview of mammary gland development, with emphasis on the role of Cxs in 
      development and tumorigenesis of this tissue. We also discuss the role of Wnt 
      signaling in similar contexts, and review the literature illustrating interplay 
      between Cxs and Wnt pathways.
FAU - Fostok, Sabreen F
AU  - Fostok SF
AD  - Department of Biology, Faculty of Arts and Sciences, American University of 
      Beirut (AUB), P.O. Box: 11-0236, Beirut, Lebanon.
FAU - El-Sibai, Mirvat
AU  - El-Sibai M
AD  - Department of Natural Sciences, School of Arts and Sciences, Lebanese American 
      University (LAU), Beirut, Lebanon.
FAU - El-Sabban, Marwan
AU  - El-Sabban M
AD  - Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of 
      Medicine, American University of Beirut (AUB), Beirut, Lebanon.
FAU - Talhouk, Rabih S
AU  - Talhouk RS
AUID- ORCID: 0000-0002-1544-1736
AD  - Department of Biology, Faculty of Arts and Sciences, American University of 
      Beirut (AUB), P.O. Box: 11-0236, Beirut, Lebanon. rtalhouk@aub.edu.lb.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180907
PL  - United States
TA  - J Mammary Gland Biol Neoplasia
JT  - Journal of mammary gland biology and neoplasia
JID - 9601804
RN  - 0 (Connexins)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/*pathology
MH  - Carcinogenesis/*pathology
MH  - Connexins/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Gap Junctions/*pathology
MH  - Humans
MH  - Mammary Glands, Animal/cytology/growth & development/*pathology
MH  - Mammary Glands, Human/cytology/growth & development/*pathology
MH  - *Wnt Signaling Pathway
MH  - beta Catenin/metabolism
OTO - NOTNLM
OT  - Breast Cancer
OT  - Connexins
OT  - Gap junctions
OT  - Mammary gland
OT  - Wnt pathways
EDAT- 2018/09/09 06:00
MHDA- 2020/07/22 06:00
CRDT- 2018/09/09 06:00
PHST- 2018/06/12 00:00 [received]
PHST- 2018/09/03 00:00 [accepted]
PHST- 2018/09/09 06:00 [pubmed]
PHST- 2020/07/22 06:00 [medline]
PHST- 2018/09/09 06:00 [entrez]
AID - 10.1007/s10911-018-9411-5 [pii]
AID - 10.1007/s10911-018-9411-5 [doi]
PST - ppublish
SO  - J Mammary Gland Biol Neoplasia. 2019 Mar;24(1):17-38. doi: 
      10.1007/s10911-018-9411-5. Epub 2018 Sep 7.