PMID- 30195627
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1096-0961 (Electronic)
IS  - 1079-9796 (Linking)
VI  - 73
DP  - 2018 Nov
TI  - The clinical features and prognosis of the monoclonal gammopathy undetermined 
      significance: A single center study.
PG  - 9-13
LID - S1079-9796(18)30261-4 [pii]
LID - 10.1016/j.bcmd.2018.08.002 [doi]
AB  - The aim of this study was to identify the clinical features and prognosis of 
      monoclonal gammopathy of undetermined significance (MGUS) in China. This single 
      center study enrolled 111 subjects visited in Peking University People's hospital 
      including 62 males and 49 females. Among them, IgG subtype, IgA subtype and IgM 
      subtype were 56.31%, 28.16%, 5.83% respectively. 10.7% patients had the 
      abnormality of convectional cytogenetic testing, while the interphase 
      fluorescence in situ hybridization (FISH) made the positive rate increased to 
      18.9%, and IgH rearrangement was most common. The positive rate of MAGE-C1/CT7 
      was 73.8% in MGUS, but the expression level was 0.33%, lower than that in MM. 
      After a median follow-up of 15.9 months, 5 cases were determined disease 
      progression (PD), and 1 patient had died of disease progression, two died of the 
      complication. MGUS is becoming increasingly important in China. Male had higher 
      prevalence of MGUS, the most common subtype was IgG, and the IgA subtype was much 
      higher which may be related to the air pollution. MGUS patients had a high 
      positive rate of MAGE-C1/CT7 gene, but the expression level was low. Some 
      patients with MGUS could progress to MM, systemic amyloidosis and other malignant 
      diseases.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Ma, Ling
AU  - Ma L
AD  - Peking University People's Hospital, Peking University Institute of Hematology, 
      Beijing 100044, China.
FAU - Xu, Shuang
AU  - Xu S
AD  - Peking University People's Hospital, Laboratory Medicine, Beijing 100044, China.
FAU - Wen, Lei
AU  - Wen L
AD  - Peking University People's Hospital, Peking University Institute of Hematology, 
      Beijing 100044, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Peking University People's Hospital, Peking University Institute of Hematology, 
      Beijing 100044, China.
FAU - Kang, Ying
AU  - Kang Y
AD  - Peking University People's Hospital, Peking University Institute of Hematology, 
      Beijing 100044, China.
FAU - Huang, Xiaojun
AU  - Huang X
AD  - Peking University People's Hospital, Peking University Institute of Hematology, 
      Beijing 100044, China.
FAU - Lu, Jin
AU  - Lu J
AD  - Peking University People's Hospital, Peking University Institute of Hematology, 
      Beijing 100044, China. Electronic address: lujinpeku@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20180806
PL  - United States
TA  - Blood Cells Mol Dis
JT  - Blood cells, molecules & diseases
JID - 9509932
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (MAGEC1 protein, human)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, Neoplasm/genetics
MH  - China
MH  - Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - Immunoglobulin A
MH  - Immunoglobulin G
MH  - Immunoglobulin M
MH  - Male
MH  - Middle Aged
MH  - Monoclonal Gammopathy of Undetermined 
      Significance/diagnosis/epidemiology/*pathology
MH  - Neoplasm Proteins/genetics
MH  - Prognosis
OTO - NOTNLM
OT  - Clinical features
OT  - Monoclonal gammopathy of undetermined significance
OT  - Prognosis
OT  - Single center study
OT  - Survival analysis
EDAT- 2018/09/10 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/09/10 06:00
PHST- 2018/07/30 00:00 [received]
PHST- 2018/08/04 00:00 [accepted]
PHST- 2018/09/10 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/09/10 06:00 [entrez]
AID - S1079-9796(18)30261-4 [pii]
AID - 10.1016/j.bcmd.2018.08.002 [doi]
PST - ppublish
SO  - Blood Cells Mol Dis. 2018 Nov;73:9-13. doi: 10.1016/j.bcmd.2018.08.002. Epub 2018 
      Aug 6.