PMID- 30196105
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20201218
IS  - 1879-0852 (Electronic)
IS  - 0959-8049 (Linking)
VI  - 103
DP  - 2018 Nov
TI  - Familial risk of pleural mesothelioma increased drastically in certain 
      occupations: A nationwide prospective cohort study.
PG  - 1-6
LID - S0959-8049(18)31125-0 [pii]
LID - 10.1016/j.ejca.2018.07.139 [doi]
AB  - OBJECTIVE: We aimed to explore the effect of occupation on familial risk of 
      pleural mesothelioma in a nationwide cohort study design. METHOD: The nationwide 
      Swedish Family-Cancer Database includes all Swedes born after 1931 and their 
      biological parents, totalling 16.1 million individuals with about 2.3 million 
      cancer patients. Hazards ratios (HRs) were calculated adjusting for age, sex and 
      region of residence. RESULTS: Having asbestos-related occupation in the absence 
      of family history of mesothelioma increased risk of mesothelioma more than 
      threefold (adjusted HR = 3.2, 95% confidence interval [CI]: 3.0-3.5). In those 
      who had a history of mesothelioma in their first-degree relatives and an 
      asbestos-related occupation, risk of mesothelioma dramatically increased compared 
      with individuals without such occupations and family history (without chronic 
      obstructive pulmonary disease [COPD] HR = 24, 95% CI: 15-39; with COPD 45, 95% 
      CI: 15-141). In those who had a family history of mesothelioma and no history of 
      an asbestos-related occupation, risk of mesothelioma did not show significant 
      increase compared with those who had no family history of mesothelioma and no 
      asbestos-related occupation (HR = 1.6; 95% CI: 0.7-3.8). CONCLUSION: First-degree 
      relatives of patients with pleural mesothelioma had a drastic risk of developing 
      this malignancy in case of certain occupations, which shows a gene-environment 
      interaction is probable in risk of mesothelioma.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Kharazmi, Elham
AU  - Kharazmi E
AD  - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany; Division of Preventive Oncology, National Center for Tumor 
      Diseases (NCT), Heidelberg, Germany. Electronic address: e.kharazmi@dkfz.de.
FAU - Chen, Tianhui
AU  - Chen T
AD  - Group of Molecular Epidemiology and Cancer Precision Prevention, Institute of 
      Occupational Diseases, Zhejiang Academy of Medical Sciences (ZJAMS), Hangzhou, 
      China. Electronic address: t.chen@zjams.com.cn.
FAU - Fallah, Mahdi
AU  - Fallah M
AD  - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany; Division of Preventive Oncology, National Center for Tumor 
      Diseases (NCT), Heidelberg, Germany.
FAU - Sundquist, Kristina
AU  - Sundquist K
AD  - Center for Primary Health Care Research, Lund University, Malmo, Sweden; 
      Department of Family Medicine and Community Health, Department of Population 
      Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, 
      USA; Center for Community-based Healthcare Research and Education (CoHRE), 
      Department of Functional Pathology, School of Medicine, Shimane University, 
      Japan.
FAU - Sundquist, Jan
AU  - Sundquist J
AD  - Center for Primary Health Care Research, Lund University, Malmo, Sweden; 
      Department of Family Medicine and Community Health, Department of Population 
      Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, 
      USA; Center for Community-based Healthcare Research and Education (CoHRE), 
      Department of Functional Pathology, School of Medicine, Shimane University, 
      Japan.
FAU - Albin, Maria
AU  - Albin M
AD  - Unit of Occupational Medicine, Institute of Environmental Medicine, Karolinska 
      Institutet, Stockholm, Sweden; Department of Occupational and Environmental 
      Medicine, Lund University, Lund, Sweden.
FAU - Weiderpass, Elisabete
AU  - Weiderpass E
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 
      Stockholm, Sweden; Cancer Registry of Norway, Institute of Population-based 
      Cancer Research, Department of Research, Oslo, Norway; Department of Community 
      Medicine, University of Tromso, The Arctic University of Norway, Tromso, Norway; 
      Genetic Epidemiology Group, Folkhalsan Research Center, Faculty of Medicine, 
      University of Helsinki, Helsinki, Finland.
FAU - Hemminki, Kari
AU  - Hemminki K
AD  - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg, Germany; Center for Primary Health Care Research, Lund University, 
      Malmo, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180906
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*etiology/pathology
MH  - Male
MH  - Mesothelioma/*etiology/pathology
MH  - Mesothelioma, Malignant
MH  - Occupational Exposure/*adverse effects
MH  - Pleural Neoplasms/*etiology/pathology
MH  - Prospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Familial risk
OT  - First-degree relatives
OT  - Mesothelioma
OT  - Occupation
EDAT- 2018/09/10 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/09/10 06:00
PHST- 2018/07/03 00:00 [received]
PHST- 2018/07/23 00:00 [accepted]
PHST- 2018/09/10 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/09/10 06:00 [entrez]
AID - S0959-8049(18)31125-0 [pii]
AID - 10.1016/j.ejca.2018.07.139 [doi]
PST - ppublish
SO  - Eur J Cancer. 2018 Nov;103:1-6. doi: 10.1016/j.ejca.2018.07.139. Epub 2018 Sep 6.