PMID- 30196649 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2005-6443 (Print) IS - 2092-6715 (Electronic) IS - 2005-6443 (Linking) VI - 39 IP - 5 DP - 2018 Sep TI - Association between Serum Uric Acid and Oxidative Stress in Korean Adults. PG - 295-299 LID - 10.4082/kjfm.17.0034 [doi] AB - BACKGROUND: Oxidative stress is implicated in the pathogenesis and development of lifestyle-related diseases. In the present study, we evaluated the correlation between the serum uric acid (UA) levels and oxidative status in Korean adults. METHODS: The subjects were 5,093 individuals (2,041 women and 3,052 men) who underwent a health checkup between June 2012 and December 2016. Oxidative stress levels (derivatives of reactive oxygen metabolites [d-ROMs]) and antioxidant potential (biological antioxidant potential [BAP]) were measured. Metabolic markers, including UA, were also examined. RESULTS: Higher serum UA levels were associated with decreased levels of d-ROMs (P<0.05). The UA levels were positively associated with BAP levels (P<0.001). CONCLUSION: Serum UA is related to oxidative status, especially antioxidant capacity, in Korean adults; UA may play a role in antioxidant defense systems in humans. FAU - Ok, Eun Jeong AU - Ok EJ AD - Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea. FAU - Kim, Kiyoung AU - Kim K AD - Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea. FAU - Park, Sat Byul AU - Park SB AD - Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea. LA - eng PT - Journal Article DEP - 20180910 PL - Korea (South) TA - Korean J Fam Med JT - Korean journal of family medicine JID - 101502902 PMC - PMC6166115 OTO - NOTNLM OT - Antioxidants OT - Oxidative Stress OT - Reactive Oxygen Species OT - Uric Acid COIS- No potential conflict of interest relevant to this article was reported. EDAT- 2018/09/11 06:00 MHDA- 2018/09/11 06:01 PMCR- 2018/09/01 CRDT- 2018/09/11 06:00 PHST- 2017/03/03 00:00 [received] PHST- 2017/10/12 00:00 [accepted] PHST- 2018/09/11 06:00 [pubmed] PHST- 2018/09/11 06:01 [medline] PHST- 2018/09/11 06:00 [entrez] PHST- 2018/09/01 00:00 [pmc-release] AID - kjfm.17.0034 [pii] AID - kjfm-17-0034 [pii] AID - 10.4082/kjfm.17.0034 [doi] PST - ppublish SO - Korean J Fam Med. 2018 Sep;39(5):295-299. doi: 10.4082/kjfm.17.0034. Epub 2018 Sep 10.