PMID- 30197703 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220321 IS - 1874-3129 (Print) IS - 1874-3129 (Electronic) IS - 1874-3129 (Linking) VI - 12 DP - 2018 TI - MicroRNA155 Expression in Relation to BDCAF Scored Behcet's Disease in an Egyptian Patients' Sample. PG - 115-122 LID - 10.2174/1874312901812010115 [doi] AB - OBJECTIVE: To discover the possibility of using microRNA155 (miRNA155) expression level as a biomarker of Behcet's Disease (BD) activity or remission. METHODS: Thirty BD patients' white blood cells (WBCs) miRNA155 expression was measured and compared to WBCs miRNA155 expression in 15 healthy subjects. Assessment of disease activity was done using Behcet's Disease Current Activity Form (BDCAF). RESULTS: miRNA155 expression significantly decreases with the increase of BD activity scored by BDCAF. CONCLUSION: Increased miRNA155 may be used as a biomarker of BD remission and thus in the disease follow up. There could be a prospect of treating the disease via microRNA 155 effect enhancement. FAU - Hassouna, Sally S AU - Hassouna SS AD - Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt. FAU - Tayel, Manal Y AU - Tayel MY AD - Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt. FAU - ElKaffash, Dalal M AU - ElKaffash DM AD - Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. FAU - Abdelhady, Ahmed M AU - Abdelhady AM AD - Department of Opthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. FAU - Elsayed, Eman H AU - Elsayed EH AD - Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt. LA - eng PT - Journal Article DEP - 20180731 PL - United Arab Emirates TA - Open Rheumatol J JT - The open rheumatology journal JID - 101480507 PMC - PMC6110073 OTO - NOTNLM OT - BDCAF OT - Behcet's disease OT - CD40 OT - Egyptian patients OT - MicroRNA155 OT - miRNA155 EDAT- 2018/09/11 06:00 MHDA- 2018/09/11 06:01 PMCR- 2018/01/01 CRDT- 2018/09/11 06:00 PHST- 2018/04/14 00:00 [received] PHST- 2018/05/19 00:00 [revised] PHST- 2018/06/22 00:00 [accepted] PHST- 2018/09/11 06:00 [entrez] PHST- 2018/09/11 06:00 [pubmed] PHST- 2018/09/11 06:01 [medline] PHST- 2018/01/01 00:00 [pmc-release] AID - TORJ-12-115 [pii] AID - 10.2174/1874312901812010115 [doi] PST - epublish SO - Open Rheumatol J. 2018 Jul 31;12:115-122. doi: 10.2174/1874312901812010115. eCollection 2018.