PMID- 30200784
OWN - NLM
STAT- MEDLINE
DCOM- 20200228
LR  - 20200228
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 44
IP  - 1
DP  - 2019 Jan
TI  - Macular Thickness and Mesopic Visual Acuity in Healthy Older Subjects.
PG  - 82-88
LID - 10.1080/02713683.2018.1522648 [doi]
AB  - Purpose/Aim: Impaired mesopic visual acuity (VA) is a risk factor for incident 
      early age-related macular degeneration (AMD) This study examines relationships 
      between macular thickness measurements and photopic or mesopic VA in healthy 
      eyes. MATERIALS AND METHODS: In 38 young and 39 older healthy individuals, total, 
      inner, and outer retinal layer (IRL and ORL) thicknesses were measured in the 
      macula region through spectral-domain optical coherence tomography (SD-OCT). 
      Measurements were made across three subfields centered at the fovea: central 
      foveal, pericentral, and peripheral. Best-corrected distance high-contrast (HC) 
      and low-contrast (LC) VA were measured using Bailey-Lovie logMAR letter charts 
      under photopic and mesopic luminance conditions. In addition, the low luminance 
      deficit in VA (LLD, difference between photopic and mesopic VA) was calculated. 
      Relationships were examined through Spearman correlation in each age group and 
      through multiple linear regressions across all eyes. RESULTS: No significant 
      correlations were detected between photopic VA (HC-VA and LC-VA) and macular 
      thickness measurements in each age group. In mesopic conditions, age and pupil 
      size were independent predictors of HC-VA (p = 0.001) and age and pericentral ORL 
      thickness predictors of LC-VA (p = 0.001). Central foveal thickness emerged as 
      the unique independent predictor of LLD (HC-VA, p = 0.013 and LC-VA, p = 0.005). 
      Only in the older age group, was central foveal thicknesses correlated with LLD 
      (HC-VA, r = + 0.45; p = 0.004 and LC-VA, r = + 0.33, p = 0.038). CONCLUSIONS: 
      Greater macular thicknesses were related to worse mesopic VA and low luminance 
      deficit in healthy subjects.
FAU - Puell, Maria Cinta
AU  - Puell MC
AUID- ORCID: 0000-0002-9227-4927
AD  - a Applied Vision Research Group, Faculty of Optics and Optometry , Universidad 
      Complutense de Madrid , Madrid , Spain.
FAU - Perez-Carrasco, Maria Jesus
AU  - Perez-Carrasco MJ
AD  - a Applied Vision Research Group, Faculty of Optics and Optometry , Universidad 
      Complutense de Madrid , Madrid , Spain.
FAU - Palomo Alvarez, Catalina
AU  - Palomo Alvarez C
AD  - a Applied Vision Research Group, Faculty of Optics and Optometry , Universidad 
      Complutense de Madrid , Madrid , Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180927
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
SB  - IM
MH  - Female
MH  - Humans
MH  - Macula Lutea/*anatomy & histology
MH  - Male
MH  - Middle Aged
MH  - Vision Tests
MH  - *Visual Acuity
OTO - NOTNLM
OT  - Optical coherence tomography
OT  - healthy eyes
OT  - low luminance deficit
OT  - macular thickness
OT  - mesopic visual acuity
EDAT- 2018/09/12 06:00
MHDA- 2020/02/29 06:00
CRDT- 2018/09/12 06:00
PHST- 2018/09/12 06:00 [pubmed]
PHST- 2020/02/29 06:00 [medline]
PHST- 2018/09/12 06:00 [entrez]
AID - 10.1080/02713683.2018.1522648 [doi]
PST - ppublish
SO  - Curr Eye Res. 2019 Jan;44(1):82-88. doi: 10.1080/02713683.2018.1522648. Epub 2018 
      Sep 27.