PMID- 30201460
OWN - NLM
STAT- MEDLINE
DCOM- 20190117
LR  - 20190117
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 27
IP  - 12
DP  - 2018 Dec
TI  - Reduction of Ischemia Reperfusion-Related Brain Hemorrhage by Stachybotrys 
      Microspora Triprenyl Phenol-7 in Mice With Antioxidant Effects.
PG  - 3521-3528
LID - S1052-3057(18)30460-9 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2018.08.018 [doi]
AB  - BACKGROUND: Stachybotrys microspora triprenyl phenol-7 (SMTP-7) has both 
      thrombolytic and anti-inflammatory effects, but its neuroprotective effects on 
      cerebral ischemia are still unclear. The present study assessed the antioxidative 
      and neurovascular unit (NVU) protective effects of SMTP-7 using transient middle 
      cerebral artery occlusion (tMCAO) mice. METHODS: After 60 minutes tMCAO, 0.9% 
      NaCl, tissue-type plasminogen activator (tPA), SMTP-7 or tPA + SMTP-7 was 
      intravenously administrated through subclavian vein just before the reperfusion, 
      and these mice were examined at 24 hours after reperfusion. We histologically 
      assessed the hemorrhage and expressive changes of antioxidative markers in 
      brains. RESULTS: SMTP-7 treatment showed a similar antithrombotic effect to tPA, 
      but significantly decreased the hemorrhage volumes and the number of 4-HNE, 3-NT 
      and 8-OHdG positive cells, meanwhile, ameliorated the decrease of collagen IV in 
      the ischemic brains. However, tPA + SMTP-7 treatment did not decrease hemorrhage 
      volumes nor showed NVU protective effect. CONCLUSIONS: The present study 
      suggested that SMTP-7 provided therapeutic benefits for ischemic stroke through 
      antioxidative and NVU protective effects unlike tPA alone or tPA + SMTP-7.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Huang, Yong
AU  - Huang Y
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Ohta, Yasuyuki
AU  - Ohta Y
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Shang, Jingwei
AU  - Shang J
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Li, Xianghong
AU  - Li X
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Liu, Xia
AU  - Liu X
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Shi, Xiaowen
AU  - Shi X
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Feng, Tian
AU  - Feng T
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Yamashita, Toru
AU  - Yamashita T
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Sato, Kota
AU  - Sato K
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Takemoto, Mami
AU  - Takemoto M
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Hishikawa, Nozomi
AU  - Hishikawa N
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.
FAU - Suzuki, Eriko
AU  - Suzuki E
AD  - Department of Applied Biological Science, Tokyo Noko University, Fuchu, Tokyo, 
      Japan.
FAU - Hasumi, Keiji
AU  - Hasumi K
AD  - Department of Applied Biological Science, Tokyo Noko University, Fuchu, Tokyo, 
      Japan.
FAU - Abe, Koji
AU  - Abe K
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan. Electronic 
      address: p4wi2ykv@yahoo.co.jp.
LA  - eng
PT  - Journal Article
DEP - 20180907
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0 (Antioxidants)
RN  - 0 (Benzopyrans)
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Pyrrolidinones)
RN  - 0 (SMTP 7)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Benzopyrans/*pharmacology
MH  - Brain/drug effects/metabolism/pathology
MH  - Disease Models, Animal
MH  - Fibrinolytic Agents/pharmacology
MH  - Infarction, Middle Cerebral Artery/*drug therapy/metabolism/pathology
MH  - Intracranial Hemorrhages/*drug therapy/etiology/metabolism/pathology
MH  - Male
MH  - Mice, Inbred ICR
MH  - Neuroprotective Agents/*pharmacology
MH  - Pyrrolidinones/*pharmacology
MH  - Reperfusion Injury/*drug therapy/metabolism/pathology
MH  - Tissue Plasminogen Activator/pharmacology
OTO - NOTNLM
OT  - Antioxidative
OT  - SMTP-7
OT  - Tpa
OT  - ischemic stroke
OT  - neurovascular unit
EDAT- 2018/09/12 06:00
MHDA- 2019/01/18 06:00
CRDT- 2018/09/12 06:00
PHST- 2018/07/15 00:00 [received]
PHST- 2018/08/03 00:00 [revised]
PHST- 2018/08/08 00:00 [accepted]
PHST- 2018/09/12 06:00 [pubmed]
PHST- 2019/01/18 06:00 [medline]
PHST- 2018/09/12 06:00 [entrez]
AID - S1052-3057(18)30460-9 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2018.08.018 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2018 Dec;27(12):3521-3528. doi: 
      10.1016/j.jstrokecerebrovasdis.2018.08.018. Epub 2018 Sep 7.