PMID- 30201543
OWN - NLM
STAT- MEDLINE
DCOM- 20191213
LR  - 20191217
IS  - 1531-4332 (Electronic)
IS  - 1095-6433 (Linking)
VI  - 227
DP  - 2019 Jan
TI  - Regulation of mitochondrial biosynthesis and function by dietary carbohydrate 
      levels and lipid sources in juvenile blunt snout bream Megalobrama amblycephala.
PG  - 14-24
LID - S1095-6433(18)30129-6 [pii]
LID - 10.1016/j.cbpa.2018.08.008 [doi]
AB  - This study aimed to investigate the effects of dietary non-protein energy 
      adjustments on the mitochondrial biosynthesis and function of juvenile 
      Megalobrama amblycephala. Fish (average weight: 37.98 +/- 0.07 g) were fed eight 
      diets containing two dietary carbohydrate levels (30% and 43%) and four lipid 
      sources (fish oil, soybean oil, palm oil and the mixed oil) for 11 weeks. Liver 
      mitochondrial respiratory chain complex V activity and ATP (adenosine 
      triphosphate) content both increased significantly with increasing dietary 
      carbohydrate levels, whereas the opposite was true for the AMP (adenosine 
      5'-monophosphate)/ATP ratio, hepatic transcripts of AMP-activated protein kinase 
      alpha1 (AMPKalpha1), AMPKalpha2, peroxisome proliferators gamma-activated receptor coativator-1alpha 
      (PGC-1alpha), NADH dehydrogenase 1 and cytochrome c oxidase 1 (COX1) as well as the 
      activities of Na(+)-K(+)-ATPase, succinate dehydrogenase (SDH), citrate synthase 
      (CS) and mitochondrial respiratory chain complex I, III and IV. Additionally, 
      hepatic ATP content, the transcripts of AMPKalpha, COX1 and ATP6 and the activities 
      of Na(+)-K(+)-ATPase, SDH, CS and mitochondrial respiratory chain complex III 
      were all significantly affected by lipid sources. Furthermore, an interaction 
      between dietary carbohydrate levels and lipid sources was also observed in the 
      activities of liver mitochondrial Na(+)-K(+)-ATPase and respiratory chain complex 
      III as well as the transcripts of ATP6 and PGC-1alpha. Overall, these findings 
      suggested that dietary carbohydrate levels and lipid sources remarkably affected 
      the mitochondrial biosynthesis and function of M. amblycephala. A diet containing 
      30% carbohydrate and FO could boost its mitochondrial biosynthesis, while that of 
      30% carbohydrate and SO could enhance the mitochondrial function.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Li, Xiang-Fei
AU  - Li XF
AD  - Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College 
      of Animal Science and Technology, Nanjing Agricultural University, No.1 Weigang 
      Road, Nanjing 210095, People's Republic of China.
FAU - Wang, Bing-Ke
AU  - Wang BK
AD  - Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College 
      of Animal Science and Technology, Nanjing Agricultural University, No.1 Weigang 
      Road, Nanjing 210095, People's Republic of China.
FAU - Xu, Chao
AU  - Xu C
AD  - Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College 
      of Animal Science and Technology, Nanjing Agricultural University, No.1 Weigang 
      Road, Nanjing 210095, People's Republic of China.
FAU - Shi, Hua-Juan
AU  - Shi HJ
AD  - Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College 
      of Animal Science and Technology, Nanjing Agricultural University, No.1 Weigang 
      Road, Nanjing 210095, People's Republic of China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College 
      of Animal Science and Technology, Nanjing Agricultural University, No.1 Weigang 
      Road, Nanjing 210095, People's Republic of China.
FAU - Liu, Jia-Dai
AU  - Liu JD
AD  - Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College 
      of Animal Science and Technology, Nanjing Agricultural University, No.1 Weigang 
      Road, Nanjing 210095, People's Republic of China.
FAU - Tian, Hong-Yan
AU  - Tian HY
AD  - Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College 
      of Animal Science and Technology, Nanjing Agricultural University, No.1 Weigang 
      Road, Nanjing 210095, People's Republic of China.
FAU - Liu, Wen-Bin
AU  - Liu WB
AD  - Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College 
      of Animal Science and Technology, Nanjing Agricultural University, No.1 Weigang 
      Road, Nanjing 210095, People's Republic of China. Electronic address: 
      wbliu@njau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180907
PL  - United States
TA  - Comp Biochem Physiol A Mol Integr Physiol
JT  - Comparative biochemistry and physiology. Part A, Molecular & integrative 
      physiology
JID - 9806096
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Enzymes)
RN  - 0 (Fish Proteins)
RN  - 415SHH325A (Adenosine Monophosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Monophosphate/metabolism
MH  - Adenosine Triphosphate/metabolism
MH  - Animal Feed
MH  - Animals
MH  - Cyprinidae/*metabolism
MH  - Dietary Carbohydrates/*metabolism
MH  - Electron Transport
MH  - Enzymes/genetics/metabolism
MH  - Fish Proteins/metabolism
MH  - *Lipid Metabolism
MH  - Mitochondria, Liver/enzymology/*metabolism
OTO - NOTNLM
OT  - Blunt snout bream
OT  - Carbohydrate level
OT  - Lipid source
OT  - Mitochondrial biosynthesis
OT  - Mitochondrial function
EDAT- 2018/09/12 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/09/12 06:00
PHST- 2018/02/06 00:00 [received]
PHST- 2018/08/04 00:00 [revised]
PHST- 2018/08/13 00:00 [accepted]
PHST- 2018/09/12 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/09/12 06:00 [entrez]
AID - S1095-6433(18)30129-6 [pii]
AID - 10.1016/j.cbpa.2018.08.008 [doi]
PST - ppublish
SO  - Comp Biochem Physiol A Mol Integr Physiol. 2019 Jan;227:14-24. doi: 
      10.1016/j.cbpa.2018.08.008. Epub 2018 Sep 7.