PMID- 30202165
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1013-9052 (Print)
IS  - 1658-3558 (Electronic)
IS  - 1013-9052 (Linking)
VI  - 30
IP  - 4
DP  - 2018 Oct
TI  - MIP-1alpha and MCP-1 as salivary biomarkers in periodontal disease.
PG  - 292-298
LID - 10.1016/j.sdentj.2018.07.002 [doi]
AB  - AIM: Chemokines released by different host cells when exposed to the components 
      of periodontopathic bacteria induce and maintain an inflammatory response in the 
      periodontium. The aim of the study was to estimate the salivary levels of two 
      chemokines, macrophage inflammatory protein-1 alpha (MIP-1alpha) and monocyte chemo 
      attractant protein-1 (MCP-1) in health, gingivitis and periodontitis and to 
      evaluate their role as reliable salivary biomarkers in discriminating gingivitis 
      and periodontitis from health. METHODS: A cross sectional study was designed to 
      estimate the levels of MIP-1alpha and MCP-1 in whole unstimulated saliva from 75 
      patients who were divided into healthy (Group 1, n = 25), gingivitis (Group 2, n 
      = 25) and chronic generalized periodontitis (Group 3, n = 25). MIP-1alpha and MCP-1 
      levels were estimated by using ELISA and were correlated with clinical 
      parameters. ROC curve analysis was done to determine the sensitivity and 
      specificity of these biomarkers in distinguishing periodontal disease from 
      health. RESULTS: Both the biomarkers were detected in all the saliva samples. 
      There was a statistically significant difference in the concentration of both the 
      analytes in Group 3 and Group 2 compared with Group 1 (p < 0.001). ROC curve 
      analysis showed 100% sensitivity and specificity for MIP-1alpha and MCP-1 in 
      discriminating periodontitis from health. For discriminating gingivitis from 
      health, MIP-1alpha had a higher sensitivity and specificity (100% & 88% respectively) 
      compared to MCP-1(84.1% & 80% respectively). CONCLUSION: There is a substantial 
      increase in the concentration of both MIP-1alpha and MCP-1 with increasing severity 
      of periodontal disease. Both the analytes showed promising results as biomarkers 
      for discriminating periodontal disease from health.
FAU - Nisha, K J
AU  - Nisha KJ
AD  - Department of Periodontics, Vydehi Institute of Dental Sciences and Research 
      Centre, EPIP Zone, Whitefield, Bangalore, Karnataka 560066, India.
FAU - Suresh, Aparnna
AU  - Suresh A
AD  - Department of Periodontics, Vydehi Institute of Dental Sciences and Research 
      Centre, EPIP Zone, Whitefield, Bangalore, Karnataka 560066, India.
FAU - Anilkumar, A
AU  - Anilkumar A
AD  - Department of Periodontics, Vydehi Institute of Dental Sciences and Research 
      Centre, EPIP Zone, Whitefield, Bangalore, Karnataka 560066, India.
FAU - Padmanabhan, Shyam
AU  - Padmanabhan S
AD  - Department of Periodontics, Vydehi Institute of Dental Sciences and Research 
      Centre, EPIP Zone, Whitefield, Bangalore, Karnataka 560066, India.
LA  - eng
PT  - Journal Article
DEP - 20180706
PL  - Saudi Arabia
TA  - Saudi Dent J
JT  - The Saudi dental journal
JID - 9313603
PMC - PMC6128325
OTO - NOTNLM
OT  - Chemokines
OT  - Macrophage inflammatory protein-1
OT  - Monocyte chemoattractant protein-1
OT  - Periodontal diseases
OT  - Saliva
EDAT- 2018/09/12 06:00
MHDA- 2018/09/12 06:01
PMCR- 2018/07/06
CRDT- 2018/09/12 06:00
PHST- 2018/04/28 00:00 [received]
PHST- 2018/06/05 00:00 [revised]
PHST- 2018/07/01 00:00 [accepted]
PHST- 2018/09/12 06:00 [entrez]
PHST- 2018/09/12 06:00 [pubmed]
PHST- 2018/09/12 06:01 [medline]
PHST- 2018/07/06 00:00 [pmc-release]
AID - S1013-9052(18)30194-9 [pii]
AID - 10.1016/j.sdentj.2018.07.002 [doi]
PST - ppublish
SO  - Saudi Dent J. 2018 Oct;30(4):292-298. doi: 10.1016/j.sdentj.2018.07.002. Epub 
      2018 Jul 6.