PMID- 30203627
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181114
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Print)
IS  - 0353-9504 (Linking)
VI  - 59
IP  - 4
DP  - 2018 Aug 31
TI  - Association of levels of interleukin 17 and T-helper 17 count with symptom 
      severity and etiology of chronic heart failure: a case-control study.
PG  - 139-148
AB  - AIM: To assess the association between the levels of interleukin 17 (IL-17) and 
      T-helper 17 count and symptom severity and etiology of chronic heart failure. 
      METHODS: This single-center prospective case-control study, conducted from 
      December 1, 2015 to January 1, 2017 in Tehran Heart Center, evaluated gene 
      expression of IL-17, relative count of (CD4+IL17+) Th17 cells and CD4+ helper 
      T-cells in peripheral blood mononuclear cells of 42 patients with CHF and 42 
      matched controls. A multiple regression model assessed the predictors of 
      peripheral IL-17 expression and Th17 count in patients with CHF. RESULTS: IL-17 
      expression was increased in patients with CHF, both at baseline and after 
      stimulation. IL-17 and Th17 counts were higher in patients with advanced New York 
      Heart Association (NYHA) functional class (class IV) than in controls and 
      patients with class I. Th17 cell population expanded in patients with CHF, more 
      prominently in patients with class IV than in controls and patients with class I, 
      regardless of the ischemic or non-ischemic CHF origin. Multiple regression model 
      showed that NYHA was the only meaningful predictor of IL-17 levels and Th17 
      count. CONCLUSION: We demonstrated the lymphocytic origin of IL-17 production in 
      advanced CHF and the ability of disease severity to predict IL-17 levels. Oxford 
      Centre for Evidence-based Medicine level of evidence: 3.
FAU - Rahmati, Zahra
AU  - Rahmati Z
FAU - Amirzargar, Ali Akbar
AU  - Amirzargar AA
AD  - Ali Akbar Amirzargar, Department of Immunology, School ofMmedicine,Tehran 
      University, of Medical Sciences, Poursina Avenue, Tehran, Iran, Iran, 
      irzara@tums.ac.ir.
FAU - Saadati, Samaneh
AU  - Saadati S
FAU - Rahmani, Farzaneh
AU  - Rahmani F
FAU - Mahmoudi, Mohammad Jafar
AU  - Mahmoudi MJ
FAU - Rahnemoon, Zahra
AU  - Rahnemoon Z
FAU - Eskandari, Vajiheh
AU  - Eskandari V
FAU - Gorzin, Fatemeh
AU  - Gorzin F
FAU - Hedayat, Mona
AU  - Hedayat M
FAU - Rezaei, Nima
AU  - Rezaei N
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - CD4 Lymphocyte Count
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Female
MH  - Gene Expression Regulation/*physiology
MH  - Heart Failure/*genetics/physiopathology
MH  - Humans
MH  - Interleukin-17/*genetics
MH  - Interleukin-6/blood
MH  - Iran
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Th17 Cells/*pathology
PMC - PMC6139427
EDAT- 2018/09/12 06:00
MHDA- 2018/10/23 06:00
PMCR- 2018/08/01
CRDT- 2018/09/12 06:00
PHST- 2018/09/12 06:00 [entrez]
PHST- 2018/09/12 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2018/08/01 00:00 [pmc-release]
AID - CroatMedJ_59_0139 [pii]
AID - 10.3325/cmj.2018.59.139 [doi]
PST - ppublish
SO  - Croat Med J. 2018 Aug 31;59(4):139-148. doi: 10.3325/cmj.2018.59.139.