PMID- 30204911
OWN - NLM
STAT- MEDLINE
DCOM- 20190411
LR  - 20240402
IS  - 1749-5024 (Electronic)
IS  - 1749-5016 (Print)
IS  - 1749-5016 (Linking)
VI  - 13
IP  - 10
DP  - 2018 Oct 25
TI  - Physical pain recruits the nucleus accumbens during social distress in borderline 
      personality disorder.
PG  - 1071-1080
LID - 10.1093/scan/nsy078 [doi]
AB  - Patients with borderline personality disorder (BPD) often engage in dangerous 
      self-injurious behaviors (SIBs) as a maladaptive technique to decrease heightened 
      feelings of distress (e.g. negative feelings caused by social exclusion). The 
      reward system has recently been proposed as a plausible neural substrate, which 
      may influence the interaction between social distress and physical pain 
      processing in patients that engage in SIBs. Using functional magnetic resonance 
      imaging (fMRI) in 20 adult BPD patients with a history of SIBs and 23 healthy 
      controls (HCs), we found a hyper-activation of the nucleus accumbens (NAcc) and 
      amygdala when painful stimuli were presented to BPD patients (but not HCs) in a 
      state of heightened distress, induced via social exclusion. This differential 
      NAcc activity was mediated by anxious attachment style, which is a key 
      developmental feature of the disorder. Altogether, these results suggest a neural 
      mechanism underlying the pathophysiology of SIBs in these patients, which is 
      likely reinforced via the reward system.
FAU - Olie, Emilie
AU  - Olie E
AD  - Department of Psychiatric Emergency & Acute Care, Lapeyronie Hospital, CHU 
      Montpellier - Inserm U1061 -University of Montpellier, Montpellier, France.
FAU - Doell, Kimberly C
AU  - Doell KC
AD  - Department of Neuroscience, University of Geneva, Geneva, Switzerland.
AD  - Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland.
AD  - Geneva Neuroscience Center, University of Geneva, Geneva, Switzerland.
AD  - Department of Psychology, FPSE, University of Geneva, Geneva, Switzerland.
FAU - Corradi-Dell'Acqua, Corrado
AU  - Corradi-Dell'Acqua C
AD  - Geneva Neuroscience Center, University of Geneva, Geneva, Switzerland.
AD  - Department of Psychology, FPSE, University of Geneva, Geneva, Switzerland.
FAU - Courtet, Philippe
AU  - Courtet P
AD  - Department of Psychiatric Emergency & Acute Care, Lapeyronie Hospital, CHU 
      Montpellier - Inserm U1061 -University of Montpellier, Montpellier, France.
FAU - Perroud, Nader
AU  - Perroud N
AD  - Department of Mental Health and Psychiatry, University Hospitals of Geneva, 
      Geneva, Switzerland.
AD  - Department of Psychiatry, University of Geneva, Geneva, Switzerland.
FAU - Schwartz, Sophie
AU  - Schwartz S
AD  - Department of Neuroscience, University of Geneva, Geneva, Switzerland.
AD  - Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland.
AD  - Geneva Neuroscience Center, University of Geneva, Geneva, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Soc Cogn Affect Neurosci
JT  - Social cognitive and affective neuroscience
JID - 101288795
SB  - IM
MH  - Adult
MH  - Amygdala/diagnostic imaging
MH  - Borderline Personality Disorder/*diagnostic imaging/psychology
MH  - Emotions
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Nucleus Accumbens/*diagnostic imaging
MH  - Pain/*diagnostic imaging/psychology
MH  - *Psychological Distance
MH  - Reward
MH  - Young Adult
PMC - PMC6204482
EDAT- 2018/09/12 06:00
MHDA- 2019/04/12 06:00
PMCR- 2018/09/11
CRDT- 2018/09/12 06:00
PHST- 2018/02/19 00:00 [received]
PHST- 2018/09/04 00:00 [accepted]
PHST- 2018/09/12 06:00 [pubmed]
PHST- 2019/04/12 06:00 [medline]
PHST- 2018/09/12 06:00 [entrez]
PHST- 2018/09/11 00:00 [pmc-release]
AID - 5094737 [pii]
AID - nsy078 [pii]
AID - 10.1093/scan/nsy078 [doi]
PST - ppublish
SO  - Soc Cogn Affect Neurosci. 2018 Oct 25;13(10):1071-1080. doi: 10.1093/scan/nsy078.