PMID- 30205096
OWN - NLM
STAT- MEDLINE
DCOM- 20181115
LR  - 20181115
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 211
DP  - 2018 Oct 15
TI  - Malaysian propolis, metformin and their combination, exert hepatoprotective 
      effect in streptozotocin-induced diabetic rats.
PG  - 40-50
LID - S0024-3205(18)30563-0 [pii]
LID - 10.1016/j.lfs.2018.09.018 [doi]
AB  - AIMS: Hepatic oxidative stress and weak antioxidant defence system resulting in 
      hepatic lesion, has been reported in diabetic rats. The present study 
      investigated the possible hepatoprotective effects of Malaysian propolis (MP) in 
      diabetic rats, on the background that MP has been reported to have 
      anti-hyperglycemic, antioxidant and anti-inflammatory effects. MATERIALS AND 
      METHODS: Sprague-Dawley rats were randomly divided into 5 groups, namely: normal 
      control (NC), diabetic control (DC), diabetic on 300 mg/kg b.w. MP, diabetic on 
      300 mg/kg b.w. metformin, and diabetic on MP and metformin combined therapy. 
      Treatment was done orally for 4 weeks, and NC and DC groups received distilled 
      water as vehicle. KEY FINDINGS: Results showed increased fasting blood glucose 
      and serum markers of hepatic lesion (aspartate aminotransferase, alkaline 
      phosphatase, alanine aminotransferase and gamma-glutamyl transferase), increased 
      hepatic lactate dehydrogenase activity, decreased hepatic superoxide dismutase, 
      catalase, glutathione peroxidase, glutathione-S-transferase and glutathione 
      reductase activities, increased immunoexpressions of nuclear factor kappa B, 
      tumor necrosis factor-alpha, interleukin(IL)-1beta and caspase-3, and decreased 
      immunoexpressions of IL-10 and proliferating cell nuclear antigen in the liver of 
      DC group. Histopathology of the liver revealed numerous hepatocytes with pyknotic 
      nuclei and inflammatory infiltration, while periodic acid-schiff staining 
      decreased in the liver of DC group. Treatment with MP attenuated these negative 
      effects and was comparable to metformin. Furthermore, these effects were better 
      attenuated in the combined therapy-treated diabetic rats. SIGNIFICANCE: Malaysian 
      propolis attenuates hepatic lesion in DM and exerts a synergistic protective 
      effect with the anti-hyperglycemic medication, metformin.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Nna, Victor Udo
AU  - Nna VU
AD  - Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 
      16150 Kubang Kerian, Kelantan, Malaysia; Department of Physiology, Faculty of 
      Basic Medical Sciences, College of Medical Sciences, University of Calabar, 
      P.M.B. 1115, Calabar, Cross River State, Nigeria.
FAU - Bakar, Ainul Bahiyah Abu
AU  - Bakar ABA
AD  - Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 
      16150 Kubang Kerian, Kelantan, Malaysia.
FAU - Mohamed, Mahaneem
AU  - Mohamed M
AD  - Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 
      16150 Kubang Kerian, Kelantan, Malaysia; Unit of Integrative Medicine, School of 
      Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, 
      Malaysia. Electronic address: mahaneem@usm.my.
LA  - eng
PT  - Journal Article
DEP - 20180908
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Drug Combinations)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Protective Agents)
RN  - 9009-62-5 (Propolis)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/therapeutic use
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism/pathology
MH  - Drug Combinations
MH  - Hepatocytes/*drug effects/metabolism/pathology
MH  - Hypoglycemic Agents/therapeutic use
MH  - Liver/*drug effects/metabolism/pathology
MH  - Malaysia
MH  - Male
MH  - Metformin/*therapeutic use
MH  - Oxidative Stress/drug effects
MH  - Propolis/*therapeutic use
MH  - Protective Agents/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Antioxidant
OT  - Diabetes
OT  - Inflammation
OT  - Malaysian propolis
OT  - Metformin
OT  - Oxidative stress
EDAT- 2018/09/12 06:00
MHDA- 2018/11/16 06:00
CRDT- 2018/09/12 06:00
PHST- 2018/07/24 00:00 [received]
PHST- 2018/08/18 00:00 [revised]
PHST- 2018/09/07 00:00 [accepted]
PHST- 2018/09/12 06:00 [pubmed]
PHST- 2018/11/16 06:00 [medline]
PHST- 2018/09/12 06:00 [entrez]
AID - S0024-3205(18)30563-0 [pii]
AID - 10.1016/j.lfs.2018.09.018 [doi]
PST - ppublish
SO  - Life Sci. 2018 Oct 15;211:40-50. doi: 10.1016/j.lfs.2018.09.018. Epub 2018 Sep 8.