PMID- 3020579
OWN - NLM
STAT- MEDLINE
DCOM- 19861117
LR  - 20191029
IS  - 0262-1746 (Print)
IS  - 0262-1746 (Linking)
VI  - 23
IP  - 2-3
DP  - 1986 Aug
TI  - Potentiation of 5-lipoxygenase metabolism by human neutrophils using a 
      combination of activators.
PG  - 105-8
AB  - Platelet-derived 12-hydroperoxy-5,8,10,14-icosatetraenoic acid (12-HPETE) cannot 
      increase the synthesis of leukotriene B4 metabolites by human neutrophils 
      activated by 1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (Paf Acether) at 
      10(-9) and 10(-8) M in contrast to 1 microM arachidonic acid. The combination of 
      the 3 inducers at various concentrations resulted in a potentiation of the 
      formation of leukotriene B4 metabolites suggesting that multiregulatory steps 
      play a key role to govern the 5-lipoxygenase activity. These results suggest that 
      the use of agents that can act synergistically to produce leukotrienes may be 
      worthwhile investigating to understand some aspects of the leukotriene 
      biosynthesis.
FAU - Maclouf, J
AU  - Maclouf J
FAU - Iliou, J P
AU  - Iliou JP
FAU - Del Maschio, A
AU  - Del Maschio A
LA  - eng
PT  - Journal Article
PL  - Scotland
TA  - Prostaglandins Leukot Med
JT  - Prostaglandins, leukotrienes, and medicine
JID - 8206868
RN  - 0 (Arachidonic Acids)
RN  - 0 (Leukotrienes)
RN  - 0 (Platelet Activating Factor)
RN  - 1HGW4DR56D (Leukotriene B4)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 67675-13-2 (12-HPETE)
RN  - EC 1.13.11.- (Arachidonate Lipoxygenases)
RN  - EC 1.13.11.34 (Arachidonate 5-Lipoxygenase)
SB  - IM
MH  - Arachidonate 5-Lipoxygenase/*metabolism
MH  - Arachidonate Lipoxygenases/*metabolism
MH  - Arachidonic Acid
MH  - Arachidonic Acids/*pharmacology
MH  - Drug Synergism
MH  - Humans
MH  - Leukotriene B4/metabolism
MH  - *Leukotrienes
MH  - Neutrophils/drug effects/*metabolism
MH  - Platelet Activating Factor/physiology
MH  - Stimulation, Chemical
EDAT- 1986/08/01 00:00
MHDA- 1986/08/01 00:01
CRDT- 1986/08/01 00:00
PHST- 1986/08/01 00:00 [pubmed]
PHST- 1986/08/01 00:01 [medline]
PHST- 1986/08/01 00:00 [entrez]
AID - 10.1016/0262-1746(86)90171-x [doi]
PST - ppublish
SO  - Prostaglandins Leukot Med. 1986 Aug;23(2-3):105-8. doi: 
      10.1016/0262-1746(86)90171-x.