PMID- 30206274 OWN - NLM STAT- MEDLINE DCOM- 20191028 LR - 20191028 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 8 IP - 1 DP - 2018 Sep 11 TI - Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy. PG - 13618 LID - 10.1038/s41598-018-31916-2 [doi] LID - 13618 AB - To determine the pre-procedural value of different fibrotic biomarkers and comprehensive cardiac magnetic resonance (CMR) for the prediction of poor response to ablation therapy in patients with atrial fibrillation (AF). Left atrial (LA) late gadolinium enhancement (LGE) and native LA T1 relaxation times were assessed using CMR. Plasma levels of relaxin, myeloperoxidase and serum levels of matrix metalloproteinase (MMP)-mediated cardiac specific titin fragmentation and MMP-mediated type IV collagen degradation were obtained. Poor outcome was defined by the recurrence of AF during 1-year follow-up. 61 patients were included in final analysis. Twenty (32.8%) patients had recurrence of AF. Patients with a recurrence of AF had a higher percentage of LA LGE (26.7 +/- 12.5% vs. 17.0 +/- 7.7%; P < 0.001), higher LA T1 relaxation times (856.7 +/- 112.2 ms vs. 746.8 +/- 91.0 ms; P < 0.001) and higher plasma levels of relaxin (0.69 +/- 1.34 pg/ml vs. 0.37 +/- 0.88 pg/ml; P = 0.035). In the multivariate Cox regression analysis, poor ablation outcome was best predicted by advanced LGE stage (hazard ratio (HR):5.487; P = 0.001) and T1 relaxation times (HR:1.007; P = 0.001). Pre-procedural CMR is a valuable tool for prediction of poor response to catheter ablation therapy in patients with AF. It offers various imaging techniques for outcome prediction and might be valuable for a better patient selection prior to ablation therapy. FAU - Luetkens, Julian A AU - Luetkens JA AD - Department of Radiology, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. julian.luetkens@ukbonn.de. FAU - Wolpers, Anne C AU - Wolpers AC AD - Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Beiert, Thomas AU - Beiert T AD - Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Kuetting, Daniel AU - Kuetting D AD - Department of Radiology, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Dabir, Darius AU - Dabir D AD - Department of Radiology, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Homsi, Rami AU - Homsi R AD - Department of Radiology, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Meendermann, Hendrik AU - Meendermann H AD - Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Daye, Natalie Abou AU - Daye NA AD - Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Knappe, Vincent AU - Knappe V AD - Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Karsdal, Morten AU - Karsdal M AD - Fibrosis Biology and Biomarkers, Nordic Bioscience, Herlev, Denmark. FAU - Nielsen, Signe H AU - Nielsen SH AD - Fibrosis Biology and Biomarkers, Nordic Bioscience, Herlev, Denmark. FAU - Genovese, Federica AU - Genovese F AD - Fibrosis Biology and Biomarkers, Nordic Bioscience, Herlev, Denmark. FAU - Stockigt, Florian AU - Stockigt F AD - Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Linhart, Markus AU - Linhart M AD - Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Thomas, Daniel AU - Thomas D AD - Department of Radiology, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Nickenig, Georg AU - Nickenig G AD - Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Schild, Hans H AU - Schild HH AD - Department of Radiology, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Schrickel, Jan W AU - Schrickel JW AD - Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. FAU - Andrie, Rene P AU - Andrie RP AD - Department of Internal Medicine II, University Hospital Bonn, Rheinische Friedrich-Wilhelms University, Bonn, Germany. LA - eng PT - Journal Article DEP - 20180911 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Collagen Type IV) RN - 0 (Connectin) RN - 0 (Contrast Media) RN - 9002-69-1 (Relaxin) RN - AU0V1LM3JT (Gadolinium) RN - EC 1.11.1.7 (Peroxidase) RN - EC 3.4.24.- (Matrix Metalloproteinases) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Atrial Fibrillation/blood/*diagnostic imaging/*physiopathology/therapy MH - Catheter Ablation/adverse effects MH - Collagen Type IV/blood MH - Connectin/blood MH - Contrast Media/administration & dosage MH - Female MH - Fibrosis/blood/*diagnostic imaging/*physiopathology/therapy MH - Gadolinium/administration & dosage MH - Heart Atria/diagnostic imaging/physiopathology MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Matrix Metalloproteinases/blood MH - Middle Aged MH - Peroxidase/blood MH - Proportional Hazards Models MH - Relaxin/blood PMC - PMC6134059 COIS- M.K., S.H.N. and F.G. are employees of Nordic Bioscience. All other authors declare no potential conflict of interest. EDAT- 2018/09/13 06:00 MHDA- 2019/10/29 06:00 PMCR- 2018/09/11 CRDT- 2018/09/13 06:00 PHST- 2018/05/15 00:00 [received] PHST- 2018/08/29 00:00 [accepted] PHST- 2018/09/13 06:00 [entrez] PHST- 2018/09/13 06:00 [pubmed] PHST- 2019/10/29 06:00 [medline] PHST- 2018/09/11 00:00 [pmc-release] AID - 10.1038/s41598-018-31916-2 [pii] AID - 31916 [pii] AID - 10.1038/s41598-018-31916-2 [doi] PST - epublish SO - Sci Rep. 2018 Sep 11;8(1):13618. doi: 10.1038/s41598-018-31916-2.