PMID- 30207783
OWN - NLM
STAT- MEDLINE
DCOM- 20191114
LR  - 20200930
IS  - 1522-1563 (Electronic)
IS  - 0363-6143 (Print)
IS  - 0363-6143 (Linking)
VI  - 316
IP  - 1
DP  - 2019 Jan 1
TI  - Neurovascular unit transport responses to ischemia and common coexisting 
      conditions: smoking and diabetes.
PG  - C2-C15
LID - 10.1152/ajpcell.00187.2018 [doi]
AB  - Transporters at the neurovascular unit (NVU) are vital for the regulation of 
      normal brain physiology via ion, water, and nutrients movement. In ischemic 
      stroke, the reduction of cerebral blood flow causes several complex 
      pathophysiological changes in the brain, one of which includes alterations of the 
      NVU transporters, which can exacerbate stroke outcome by increased brain edema 
      (by altering ion, water, and glutamate transporters), altered energy metabolism 
      (by altering glucose transporters), and enhanced drug toxicity (by altering 
      efflux transporters). Smoking and diabetes are common risk factors as well as 
      coexisting conditions in ischemic stroke that are also reported to change the 
      expression and function of NVU transporters. Coexistence of these conditions 
      could cause an additive effect in terms of the alterations of brain transporters 
      that might lead to worsened ischemic stroke prognosis and recovery. In this 
      review, we have discussed the effects of ischemic stroke, smoking, and diabetes 
      on some essential NVU transporters and how the simultaneous presence of these 
      conditions can affect the clinical outcome after an ischemic episode. Further 
      scientific investigations are required to elucidate changes in NVU transport in 
      cerebral ischemia, which can lead to better, personalized therapeutic 
      interventions tailor-made for these comorbid conditions.
FAU - Sifat, Ali E
AU  - Sifat AE
AD  - Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University 
      Health Sciences Center , Amarillo, Texas.
FAU - Vaidya, Bhuvaneshwar
AU  - Vaidya B
AD  - Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University 
      Health Sciences Center , Amarillo, Texas.
FAU - Villalba, Heidi
AU  - Villalba H
AD  - Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University 
      Health Sciences Center , Amarillo, Texas.
FAU - Albekairi, Thamer H
AU  - Albekairi TH
AD  - Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University 
      Health Sciences Center , Amarillo, Texas.
FAU - Abbruscato, Thomas J
AU  - Abbruscato TJ
AD  - Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University 
      Health Sciences Center , Amarillo, Texas.
LA  - eng
GR  - R01 NS076012/NS/NINDS NIH HHS/United States
GR  - R01 DA029121/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20180912
PL  - United States
TA  - Am J Physiol Cell Physiol
JT  - American journal of physiology. Cell physiology
JID - 100901225
RN  - 0 (Glucose Transport Proteins, Facilitative)
RN  - 0 (Membrane Transport Proteins)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/metabolism/pathology
MH  - Brain/metabolism/pathology
MH  - Brain Ischemia/*metabolism/pathology
MH  - Diabetes Mellitus/*metabolism/pathology
MH  - Glucose Transport Proteins, Facilitative/metabolism
MH  - Humans
MH  - Ion Transport/physiology
MH  - Membrane Transport Proteins/*metabolism
MH  - Neurons/metabolism/pathology
MH  - Neurovascular Coupling/*physiology
MH  - Smoking/*metabolism/pathology
MH  - Stroke/*metabolism/pathology
PMC - PMC6383146
OTO - NOTNLM
OT  - glucose transporters
OT  - ion transporters
OT  - ischemic stroke
OT  - neurovascular unit
EDAT- 2018/09/13 06:00
MHDA- 2019/11/15 06:00
PMCR- 2020/01/01
CRDT- 2018/09/13 06:00
PHST- 2018/09/13 06:00 [pubmed]
PHST- 2019/11/15 06:00 [medline]
PHST- 2018/09/13 06:00 [entrez]
PHST- 2020/01/01 00:00 [pmc-release]
AID - C-00187-2018 [pii]
AID - 10.1152/ajpcell.00187.2018 [doi]
PST - ppublish
SO  - Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C2-C15. doi: 
      10.1152/ajpcell.00187.2018. Epub 2018 Sep 12.