PMID- 30208748
OWN - NLM
STAT- MEDLINE
DCOM- 20190708
LR  - 20200309
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 46
IP  - 12
DP  - 2018 Dec
TI  - Positive correlation between cognitive impairment and renal microangiopathy in 
      patients with type 2 diabetic nephropathy: a multicenter retrospective study.
PG  - 5040-5051
LID - 10.1177/0300060518789299 [doi]
AB  - OBJECTIVE: This study was performed to explore the correlation between cognitive 
      impairment and renal microangiopathy in patients with type 2 diabetic nephropathy 
      (T2DN) by detecting changes in cognitive function and cerebral metabolism in 
      these patients with different stages of T2DN. METHODS: Prospectively maintained 
      databases were reviewed from 2006 to 2017. Blood biochemical indexes and the 
      urinary albumin excretion rate (UAER) were measured in all participants. 
      Cognitive function was assessed by the Mini-Mental State Examination (MMSE) and 
      Montreal Cognitive Assessment Scale (MoCA). Cognitive impairment was the primary 
      endpoint. Renal microangiopathy was the secondary endpoint. Pearson correlation 
      analysis was used to assess correlations. RESULTS: Two hundred sixteen patients 
      with type 2 diabetes mellitus (T2DM) were divided into three groups according to 
      their UAER: T2DM without nephropathy (n=72), early T2DM with nephropathy (n=74), 
      and the clinical stage of early T2DM with nephropathy (n=70). Healthy 
      participants were selected as the normal control group (n=70). Pearson 
      correlation analysis demonstrated that the total MMSE and MoCA score was 
      negatively correlated with the UAER (r=-0.327) and positively correlated with the 
      estimated glomerular filtration rate (r=0.428) in patients with T2DN. 
      CONCLUSIONS: The present study showed a positive correlation between cognitive 
      impairment and renal microangiopathy in patients with T2DN.
FAU - Li, Jinyu
AU  - Li J
AD  - 1 The First College of Clinical Medical Science, China Three Gorges University, 
      Yichang Central People's Hospital, Yichang, China.
FAU - Pan, Jiamin
AU  - Pan J
AD  - 2 Ultrasonography Department, The First Affiliated Hospital of Sun Yat-sen 
      University, Huangpu District, Guangzhou, China.
FAU - Li, Bohan
AU  - Li B
AD  - 3 Department of Microsurgery, Trauma and Hand Surgery, The First Affiliated 
      Hospital of Sun Yat-sen University, Yuexiu District, Guangzhou, China.
FAU - Tian, Huiyu
AU  - Tian H
AD  - 4 Intensive Care Unit, the First Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei Province, China.
FAU - Zhu, Ying
AU  - Zhu Y
AD  - 5 Department of Radiology, The First Affiliated Hospital of Sun Yat-sen 
      University, Yuexiu District, Guangzhou, China.
FAU - Liao, Zhihao
AU  - Liao Z
AD  - 6 Department of Microsurgery and Hand Surgery, The Third Affiliated Hospital of 
      Guangzhou University of Traditional Chinese, Guangzhou, China.
FAU - Kou, Li
AU  - Kou L
AD  - 7 Department of neurology, The Fifth Affiliated Hospital of The Fifth Affiliated 
      Hospital of Sun Yat-sen University, Zhuhai, China.
FAU - Tang, Chaogang
AU  - Tang C
AD  - 7 Department of neurology, The Fifth Affiliated Hospital of The Fifth Affiliated 
      Hospital of Sun Yat-sen University, Zhuhai, China.
FAU - Wang, Mingwei
AU  - Wang M
AD  - 8 Department of Neurology, The First Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei Province, China.
FAU - Ye, Guoqiang
AU  - Ye G
AD  - 6 Department of Microsurgery and Hand Surgery, The Third Affiliated Hospital of 
      Guangzhou University of Traditional Chinese, Guangzhou, China.
FAU - Wang, Ming
AU  - Wang M
AD  - 1 The First College of Clinical Medical Science, China Three Gorges University, 
      Yichang Central People's Hospital, Yichang, China.
LA  - eng
PT  - Journal Article
DEP - 20180912
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cognitive Dysfunction/*etiology/pathology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diabetic Nephropathies/*complications/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kidney Diseases/*etiology/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Thrombotic Microangiopathies/*etiology/pathology
PMC - PMC6300957
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - cognitive impairment
OT  - correlation
OT  - glomerular filtration rate
OT  - renal microangiopathy
OT  - urinary albumin excretion rate
EDAT- 2018/09/14 06:00
MHDA- 2019/07/10 06:00
PMCR- 2018/12/01
CRDT- 2018/09/14 06:00
PHST- 2018/09/14 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
PHST- 2018/09/14 06:00 [entrez]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 10.1177_0300060518789299 [pii]
AID - 10.1177/0300060518789299 [doi]
PST - ppublish
SO  - J Int Med Res. 2018 Dec;46(12):5040-5051. doi: 10.1177/0300060518789299. Epub 
      2018 Sep 12.