PMID- 30209532
OWN - NLM
STAT- MEDLINE
DCOM- 20190501
LR  - 20190501
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 235
IP  - 11
DP  - 2018 Nov
TI  - Comparison of the effects of abstinence on MDMA and cocaine self-administration 
      in rats.
PG  - 3233-3241
LID - 10.1007/s00213-018-5026-1 [doi]
AB  - RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA) preferentially increases 
      synaptic serotonin (5HT). This response was attenuated following repeated 
      exposure but there was recovery as a result of abstinence. Effects of abstinence 
      on self-administration of many drugs have been documented but the impact on MDMA 
      self-administration is unknown. OBJECTIVE: This study compared the effects of 
      abstinence on MDMA and cocaine self-administration. METHODS: Six-hour daily MDMA 
      or cocaine sessions were conducted until a total of 350 mg/kg had been 
      self-administered. Following this, rats were randomly assigned to either a 0- or 
      14-day abstinence group. Self-administration testing then continued for an 
      additional 7 days. RESULTS: The latency to self-administer 350 mg/kg was shorter 
      for rats that self-administered cocaine. The temporal distribution of responding 
      within each test session also differed; MDMA self-administration was high during 
      the first hour of each session, and decreased during subsequent hours, whereas 
      cocaine self-administration was evenly distributed throughout each hour of the 
      session. Abstinence decreased MDMA but not cocaine self-administration. 
      CONCLUSIONS: The selective reduction of MDMA self-administration following 
      abstinence is consistent with the idea that MDMA-stimulated 5-HT release is 
      inhibitory to MDMA self-administration.
FAU - Highgate, Quenten
AU  - Highgate Q
AD  - School of Psychology, Victoria University of Wellington, Wellington, 6011, New 
      Zealand.
FAU - Schenk, Susan
AU  - Schenk S
AUID- ORCID: 0000-0002-7786-8313
AD  - School of Psychology, Victoria University of Wellington, Wellington, 6011, New 
      Zealand. susan.schenk@vuw.ac.nz.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180912
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 333DO1RDJY (Serotonin)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/administration & dosage
MH  - Animals
MH  - Behavior, Addictive/metabolism/*psychology
MH  - Cocaine/*administration & dosage
MH  - Dopamine Uptake Inhibitors/administration & dosage
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
MH  - Serotonin/metabolism
MH  - Substance Withdrawal Syndrome/metabolism/*psychology
OTO - NOTNLM
OT  - Abstinence
OT  - Cocaine
OT  - MDMA
OT  - Self-administration
OT  - Serotonin
EDAT- 2018/09/14 06:00
MHDA- 2019/05/02 06:00
CRDT- 2018/09/14 06:00
PHST- 2018/05/13 00:00 [received]
PHST- 2018/09/04 00:00 [accepted]
PHST- 2018/09/14 06:00 [pubmed]
PHST- 2019/05/02 06:00 [medline]
PHST- 2018/09/14 06:00 [entrez]
AID - 10.1007/s00213-018-5026-1 [pii]
AID - 10.1007/s00213-018-5026-1 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2018 Nov;235(11):3233-3241. doi: 
      10.1007/s00213-018-5026-1. Epub 2018 Sep 12.