PMID- 30210070
OWN - NLM
STAT- MEDLINE
DCOM- 20191112
LR  - 20191112
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 82
IP  - 11
DP  - 2018 Oct 25
TI  - Transcatheter Repair of Functional Mitral Regurgitation in Heart Failure 
      Patients　- A Meta-Analysis of 23 Studies on MitraClip Implantation.
PG  - 2800-2810
LID - 10.1253/circj.CJ-18-0571 [doi]
AB  - BACKGROUND: The aim of this study was to investigate long-term survival, clinical 
      status, and echocardiographic findings of patients with severe functional mitral 
      regurgitation (FMR) undergoing MitraClip (MC) treatment and to explore the role 
      of baseline features on outcome. Methods and Results: Randomized and 
      observational studies of FMR patients undergoing MC treatment were collected to 
      evaluate the overall survival, New York Heart Association (NYHA) class and 
      echocardiographic changes after MC treatment. Baseline parameters associated with 
      mortality and echocardiographic changes were also investigated. Across 23 studies 
      enrolling 3,253 patients, the inhospital death rate was 2.31%, whereas the 
      mortality rate was 5.37% at 1 month, 11.87% at 6 months, 18.47% at 1 year and 
      31.08% at 2 years. Mitral regurgitation Grade <3+ was observed in 92.76% patients 
      at discharge and in 83.36% patients at follow-up. At follow-up, 76.63% of 
      patients NYHA Class I-II and there were significant improvements in left 
      ventricular (LV) volume, ejection fraction, and pulmonary pressure. Atrial 
      fibrillation (AF) had a significant negative effect on 1-year survival 
      (beta=0.18+/-0.06; P=0.0047) and on the reduction in LV end-diastolic and end-systolic 
      volumes (beta=-1.05+/-0.47 [P=0.0248] and beta=-2.60+/-0.53 [P=0.0024], respectively). 
      CONCLUSIONS: MC results in durable reductions in mitral regurgitation associated 
      with significant clinical and echocardiographic improvements in heart failure 
      patients. AF negatively affects LV reverse remodeling and 1-year survival after 
      MC treatment.
FAU - De Rosa, Roberta
AU  - De Rosa R
AD  - Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San 
      Giovanni di Dio e Ruggi d'Aragona".
FAU - Silverio, Angelo
AU  - Silverio A
AD  - Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San 
      Giovanni di Dio e Ruggi d'Aragona".
FAU - Baldi, Cesare
AU  - Baldi C
AD  - Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San 
      Giovanni di Dio e Ruggi d'Aragona".
FAU - Di Maio, Marco
AU  - Di Maio M
AD  - Division of Cardiology, Department of Cardiothoracic and Respiratory Sciences, 
      University of Campania "Luigi Vanvitelli", Monaldi Hospital, AORN "Ospedali dei 
      Colli".
FAU - Prota, Costantina
AU  - Prota C
AD  - Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San 
      Giovanni di Dio e Ruggi d'Aragona".
FAU - Radano, Ilaria
AU  - Radano I
AD  - Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San 
      Giovanni di Dio e Ruggi d'Aragona".
FAU - Rey, Julia
AU  - Rey J
AD  - Department of Medicine, Institute of Biostatistics and Mathematical Modelling, 
      Goethe University Frankfurt.
FAU - Herrmann, Eva
AU  - Herrmann E
AD  - Department of Medicine, Institute of Biostatistics and Mathematical Modelling, 
      Goethe University Frankfurt.
FAU - Citro, Rodolfo
AU  - Citro R
AD  - Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San 
      Giovanni di Dio e Ruggi d'Aragona".
FAU - Piscione, Federico
AU  - Piscione F
AD  - Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San 
      Giovanni di Dio e Ruggi d'Aragona".
FAU - Galasso, Gennaro
AU  - Galasso G
AD  - Cardiology Unit, Cardiovascular and Thoracic Department, University Hospital "San 
      Giovanni di Dio e Ruggi d'Aragona".
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20180913
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
MH  - Atrial Fibrillation/diagnostic imaging/mortality/physiopathology
MH  - Disease-Free Survival
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/diagnostic imaging/*mortality/physiopathology/*surgery
MH  - *Heart Valve Prosthesis
MH  - *Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Male
MH  - Mitral Valve Insufficiency/diagnostic imaging/*mortality/physiopathology/*surgery
MH  - Randomized Controlled Trials as Topic
MH  - Risk Factors
MH  - Survival Rate
OTO - NOTNLM
OT  - Functional mitral regurgitation
OT  - Heart failure
OT  - MitraClip
OT  - Secondary mitral regurgitation
OT  - Transcatheter mitral valve repair
EDAT- 2018/09/14 06:00
MHDA- 2019/11/13 06:00
CRDT- 2018/09/14 06:00
PHST- 2018/09/14 06:00 [pubmed]
PHST- 2019/11/13 06:00 [medline]
PHST- 2018/09/14 06:00 [entrez]
AID - 10.1253/circj.CJ-18-0571 [doi]
PST - ppublish
SO  - Circ J. 2018 Oct 25;82(11):2800-2810. doi: 10.1253/circj.CJ-18-0571. Epub 2018 
      Sep 13.