PMID- 30210299
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 12
DP  - 2018
TI  - Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and 
      Disease Brains.
PG  - 273
LID - 10.3389/fncel.2018.00273 [doi]
LID - 273
AB  - In the mature healthy mammalian neuronal networks, gamma-aminobutyric acid (GABA) 
      mediates synaptic inhibition by acting on GABA(A) and GABA(B) receptors 
      (GABA(A)R, GABA(B)R). In immature networks and during numerous pathological 
      conditions the strength of GABAergic synaptic inhibition is much less pronounced. 
      In these neurons the activation of GABA(A)R produces paradoxical depolarizing 
      action that favors neuronal network excitation. The depolarizing action of 
      GABA(A)R is a consequence of deregulated chloride ion homeostasis. In addition to 
      depolarizing action of GABA(A)R, the GABA(B)R mediated inhibition is also less 
      efficient. One of the key molecules regulating the GABAergic synaptic 
      transmission is the brain derived neurotrophic factor (BDNF). BDNF and its 
      precursor proBDNF, can be released in an activity-dependent manner. Mature BDNF 
      operates via its cognate receptors tropomyosin related kinase B (TrkB) whereas 
      proBDNF binds the p75 neurotrophin receptor (p75(NTR)). In this review article, 
      we discuss recent finding illuminating how mBDNF-TrkB and proBDNF-p75(NTR) 
      signaling pathways regulate GABA related neurotransmission under physiological 
      conditions and during epilepsy.
FAU - Porcher, Christophe
AU  - Porcher C
AD  - Aix Marseille University, Marseille, France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U901, 
      Marseille, France.
AD  - Institut de Neurobiologie de la Mediterranee (INMED), Marseille, France.
FAU - Medina, Igor
AU  - Medina I
AD  - Aix Marseille University, Marseille, France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U901, 
      Marseille, France.
AD  - Institut de Neurobiologie de la Mediterranee (INMED), Marseille, France.
FAU - Gaiarsa, Jean-Luc
AU  - Gaiarsa JL
AD  - Aix Marseille University, Marseille, France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U901, 
      Marseille, France.
AD  - Institut de Neurobiologie de la Mediterranee (INMED), Marseille, France.
LA  - eng
PT  - Journal Article
DEP - 20180828
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC6121065
OTO - NOTNLM
OT  - BDNF
OT  - GABA receptors
OT  - KCC2
OT  - TrkB
OT  - p75NTR
EDAT- 2018/09/14 06:00
MHDA- 2018/09/14 06:01
PMCR- 2018/01/01
CRDT- 2018/09/14 06:00
PHST- 2018/05/15 00:00 [received]
PHST- 2018/08/06 00:00 [accepted]
PHST- 2018/09/14 06:00 [entrez]
PHST- 2018/09/14 06:00 [pubmed]
PHST- 2018/09/14 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2018.00273 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2018 Aug 28;12:273. doi: 10.3389/fncel.2018.00273. 
      eCollection 2018.