PMID- 30210610
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 16
IP  - 3
DP  - 2018 Sep
TI  - Acetylpuerarin inhibits oxygen-glucose deprivation-induced neuroinflammation of 
      rat primary astrocytes via the suppression of HIF-1 signaling.
PG  - 2689-2695
LID - 10.3892/etm.2018.6509 [doi]
AB  - In the central nervous system (CNS), ischemic injury induced by inflammation 
      associated with astrocytes serves an important role in physiological and 
      pathological processes. Neuroinflammation leads to the release of 
      pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-1beta. 
      The aim of the present study was to investigate whether acetylpuerarin attenuates 
      oxygen-glucose deprivation (OGD)-induced astrocyte inflammation and secretion of 
      pro-inflammatory cytokines via inhibiting hypoxia-inducible factor-1 (HIF-1) 
      activation and suppressing downstream primary astrocyte signaling in rats. The 
      results demonstrated that acetylpuerarin attenuates astrocyte viability and 
      induces morphological changes following OGD stress. Furthermore, acetylpuerarin 
      suppresses the stimulation of HIF-1alpha and nuclear factor (NF)-kappaB signaling 
      pathways, while attenuating the expression and secretion of pro-inflammatory 
      cytokines via HIF-1 suppression in OGD-induced astrocytes. These findings 
      indicate that acetylpuerarin may attenuate OGD-induced astrocyte damage and 
      inflammation in rat primary astrocytes via suppressing HIF-1 activation and NF-kappaB 
      signaling. These results suggest that acetylpuerarin regulates inflammation 
      associated with astrocytes and may represent a novel therapeutic agent for the 
      treatment of neuroinflammation in the CNS.
FAU - Xiang, Yanxiao
AU  - Xiang Y
AD  - Department of Clinical Pharmacy, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, P.R. China.
FAU - Du, Pengchao
AU  - Du P
AD  - College of Basic Medicine, Binzhou Medical University, Yantai, Shandong 264033, 
      P.R. China.
FAU - Zhang, Xiumei
AU  - Zhang X
AD  - Department of Pharmacology, Shandong University School of Medicine, Jinan, 
      Shandong 250012, P.R. China.
FAU - Biswas, Siddhartha
AU  - Biswas S
AD  - Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, P.R. China.
FAU - Jiao, Guangjun
AU  - Jiao G
AD  - Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
FAU - Liu, Haichun
AU  - Liu H
AD  - Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180723
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6122535
OTO - NOTNLM
OT  - hypoxia inducible factor-1
OT  - neuroinflammation
OT  - oxygen-glucose deprivation
OT  - primary astrocytes
EDAT- 2018/09/14 06:00
MHDA- 2018/09/14 06:01
PMCR- 2018/07/23
CRDT- 2018/09/14 06:00
PHST- 2017/11/03 00:00 [received]
PHST- 2018/06/08 00:00 [accepted]
PHST- 2018/09/14 06:00 [entrez]
PHST- 2018/09/14 06:00 [pubmed]
PHST- 2018/09/14 06:01 [medline]
PHST- 2018/07/23 00:00 [pmc-release]
AID - ETM-0-0-6509 [pii]
AID - 10.3892/etm.2018.6509 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Sep;16(3):2689-2695. doi: 10.3892/etm.2018.6509. Epub 2018 Jul 
      23.